The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The C Termini of Arabidopsis Cryptochromes Mediate a Constitutive Light Response
Open accessAbstract
Cryptochrome blue light photoreceptors share sequence similarity to photolyases, flavoproteins that mediate light-dependent DNA repair. However, cryptochromes lack photolyase activity and are characterized by distinguishing C-terminal domains. Here we show that the signaling mechanism of Arabidopsis cryptochrome is mediated through the C terminus. On fusion with beta-glucuronidase (GUS), both the Arabidopsis CRY1 C-terminal domain (CCT1) and the CRY2 C-terminal domain (CCT2) mediate a constitutive light response. This constitutive photomorphogenic (COP) phenotype was not observed for mutants of cct1 corresponding to previously described cry1 alleles. We propose that the C-terminal domain of Arabidopsis cryptochrome is maintained in an inactive state in the dark. Irradiation with blue light relieves this repression, presumably through an intra- or intermolecular redox reaction mediated through the flavin bound to the N-terminal photolyase-like domain.
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Cites
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S. A., Rosbash, M., & Hall, J. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81638-4 · Cited by 968
Putative Human Blue-Light Photoreceptors hCRY1 and hCRY2 Are Flavoproteins
Hsu, D. S., Zhao, X., Zhao, S., Kazantsev, A., Wang, R.-P., Todo, T., Wei, Y.-F., & Sancar, A. (1996) · Biochemistry · doi:10.1021/bi962209o · Cited by 291
Cited by
The genetic basis of flowering responses to seasonal cues
Andrés, F., & Coupland, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3291 · Cited by 1,538
The cryptochromes: blue light photoreceptors in plants and animals
Chaves, I., Pokorny, R., Byrdin, M., Hoang, N., Ritz, T., Brettel, K., Essen, L.-O., van der Horst, G. T. J., Batschauer, A., & Ahmad, M. (2011) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042110-103759 · Cited by 845
Structure and function of plant photoreceptors
Möglich, A., Yang, X., Ayers, R. A., & Moffat, K. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112259 · Cited by 499
Cryptochrome Blue Light Photoreceptors Are Activated through Interconversion of Flavin Redox States
Bouly, J.-P., Schleicher, E., Dionisio-Sese, M., Vandenbussche, F., Van Der Straeten, D., Bakrim, N., Meier, S., Batschauer, A., Galland, P., Bittl, R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609842200 · Cited by 441
Blue Light Receptors and Signal Transduction
Lin, C. (2002) · The Plant Cell · doi:10.1105/tpc.000646 · Cited by 367
Metadata
- Authors
- Yang, H.-Q., Wu, Y.-J., Tang, R.-H., Liu, D., Liu, Y., & Cashmore, A. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 103
- Issue
- 5
- Pages
- 815-827
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1982573383
- Cited by
- 413
- References
- 2
- FWCI
- 25.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yang, H.-Q., Wu, Y.-J., Tang, R.-H., Liu, D., Liu, Y., & Cashmore, A. R. (2000). The C Termini of Arabidopsis Cryptochromes Mediate a Constitutive Light Response. Cell. https://doi.org/10.1016/s0092-8674(00)00184-7
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