Cited by 968Circadian rhythm and melatoninNeurobiology and Insect Physiology ResearchLight effects on plants

The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila

Open access
Stanewsky, Ralf, Kaneko, Maki, Emery, Patrick, Beretta, Bonnie, Wager-Smith, Karen, Kay, Steve A, Rosbash, Michael, Hall, Jeffrey C·1998·Cell

Abstract

A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles). Consistent with the fact that light normally suppresses TIM, cryb is an apparent null mutation in a gene encoding Drosophila's version of the blue light receptor cryptochrome. Behaviorally, cryb exhibits poor synchronization to light-dark cycles in genetic backgrounds that cause external blindness or demand several hours of daily rhythm resets, and it shows no response to brief light pulses. cryb flies are rhythmic in constant darkness, correlating with robust PER and TIM cycling in certain pacemaker neurons.

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(00)81638-4

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Members of the d-Cry/Cry1/Lcry family can function as photoreceptors activated by short-wavelength light in insect and annelid circadian clocks.

    “members of the d-Cry/Cry1/Lcry family can function as photoreceptors (activated by short-wavelength light) in insect and annelid circadian clocks (22, 33, 35, 36)”

    From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [36]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S. A., Rosbash, M., & Hall, J. C.
Affiliations
  • U.S. National Science Foundation (US)
  • Scripps Research Institute (US)
Corresponding author
Hall, Jeffrey C
Venue
Cell
Publisher
Elsevier BV
Published
1998-11
Volume
95
Issue
5
Pages
681-692
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2095299680
Cited by
968
References
57
Citations by year
2026: 13 · 2025: 27 · 2024: 22 · 2023: 30 · 2022: 47 · 2021: 24 · 2020: 27 · 2019: 34 · 2018: 30 · 2017: 38 · 2016: 33 · 2015: 28 · 2014: 41 · 2013: 24 · 2012: 32
FWCI
17.64
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • National Institute of Mental Health (MH-51573, R01MH051573)
  • National Institute of General Medical Sciences (P01GM033205, GM-33205)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
Keywords
cryptochrome, circadian photoreceptors, blue light receptor, Drosophila circadian clock, period gene, timeless gene, pacemaker neurons
MeSH terms
Animals, Behavior, Animal, Circadian Rhythm, Darkness, Drosophila melanogaster, Eye Proteins, Flavoproteins, Light, Neurons, Nuclear Proteins, Open Reading Frames, Photoreceptor Cells, Invertebrate, Insect Proteins, Mutation, Missense, Drosophila Proteins, Receptors, G-Protein-Coupled, Cryptochromes, Period Circadian Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review