The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
Open accessAbstract
A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles). Consistent with the fact that light normally suppresses TIM, cryb is an apparent null mutation in a gene encoding Drosophila's version of the blue light receptor cryptochrome. Behaviorally, cryb exhibits poor synchronization to light-dark cycles in genetic backgrounds that cause external blindness or demand several hours of daily rhythm resets, and it shows no response to brief light pulses. cryb flies are rhythmic in constant darkness, correlating with robust PER and TIM cycling in certain pacemaker neurons.
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Members of the d-Cry/Cry1/Lcry family can function as photoreceptors activated by short-wavelength light in insect and annelid circadian clocks.
“members of the d-Cry/Cry1/Lcry family can function as photoreceptors (activated by short-wavelength light) in insect and annelid circadian clocks (22, 33, 35, 36)”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [36]
Cites
Genetic variations of Drosophila melanogaster.
Lindsley, D. L., & Grell, E. H. (1968) · Biodiversity Heritage Library (Smithsonian Institution) · doi:10.5281/zenodo.10755360 · Cited by 2,623 · see citing works
Clock Mutants of Drosophila melanogaster
Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287 · see citing works
A stable genomic source of P element transposase in Drosophila melanogaster.
Robertson, H. M., Preston, C. R., Phillis, R. W., Johnson-Schlitz, D. M., Benz, W. K., & Engels, W. R. (1988) · Genetics · doi:10.1093/genetics/118.3.461 · Cited by 1,333 · see citing works
Light Quality, Photoperception, and Plant Strategy
Smith, H. (1982) · Annual Review of Plant Physiology · doi:10.1146/annurev.pp.33.060182.002405 · Cited by 1,253 · see citing works
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912 · see citing works
Self-citationdouble-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation
Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839 · see citing works
Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim
Darlington, T. K., Wager‐Smith, K., Ceriani, M. F., Staknis, D., Gekakis, N., Steeves, T. D. L., Weitz, C. J., Takahashi, J. S., & Kay, S. A. (1998) · Science · doi:10.1126/science.280.5369.1599 · Cited by 826 · see citing works
Self-citationAllada, R., White, N. E., So, W. V., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81440-3 · Cited by 744 · see citing works
Self-citationRutila, J. E., Suri, V., Le, M., So, W. V., Rosbash, M., & Hall, J. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81441-5 · Cited by 643 · see citing works
Self-citationIndependent Photoreceptive Circadian Clocks Throughout Drosophila
Plautz, J. D., Kaneko, M. A. N., Hall, J. C., & Kay, S. A. (1997) · Science · doi:10.1126/science.278.5343.1632 · Cited by 640 · see citing works
Self-citationCrystal Structure of DNA Photolyase from Escherichia coli
Park, H.-W., Kim, S., Sancar, A., & Deisenhofer, J. (1995) · Science · doi:10.1126/science.7604260 · Cited by 585 · see citing works
The Drosophila ninaE gene encodes an opsin
O’Tousa, J. E., Baehr, W., Martin, R. L., Hirsh, J., Pak, W. L., & Applebury, M. (1985) · Cell · doi:10.1016/0092-8674(85)90343-5 · Cited by 540 · see citing works
Neurospora wc-1 and wc-2 : Transcription, Photoresponses, and the Origins of Circadian Rhythmicity
Crosthwaite, S. K., Dunlap, J., & Loros, J. (1997) · Science · doi:10.1126/science.276.5313.763 · Cited by 503 · see citing works
A light-entrainment mechanism for the Drosophila circadian clock
Zeng, H., Qian, Z., Myers, M. P., & Rosbash, M. (1996) · Nature · doi:10.1038/380129a0 · Cited by 479 · see citing works
Self-citationMiyamoto, Y., & Sancar, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6097 · Cited by 406 · see citing works
Zerr, D., Hall, J. C., Rosbash, M., & Siwicki, K. K. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02749.1990 · Cited by 401 · see citing works
Self-citationHunter-Ensor, M., Ousley, A. H., & Sehgal, A. (1996) · Cell · doi:10.1016/s0092-8674(00)81046-6 · Cited by 395 · see citing works
Twilight Times: Light and the Circadian System
Roenneberg, T., & Foster, F. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03188.x · Cited by 379 · see citing works
Quantitative Analysis of Drosophila period Gene Transcription in Living Animals
Plautz, J. D., Straume, M., Stanewsky, R., Jamison, C. F., Brandes, C., Dowse, H. B., Hall, J. C., & Kay, S. A. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200302 · Cited by 379 · see citing works
Self-citationEwer, J., Frisch, B., Hamblen-Coyle, M., et al. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03321.1992 · Cited by 333 · see citing works
The CRY1 Blue Light Photoreceptor of Arabidopsis Interacts with Phytochrome A In Vitro
Ahmad, M., Jarillo, J. A., Smirnova, O., & Cashmore, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80094-5 · Cited by 312 · see citing works
Behavior in Light-Dark Cycles of Drosophila Mutants That Are Arrhythmic, Blind, or Both
Wheeler, D. A., Hamblen, M. J., Dushay, M. S., & Hall, J. C. (1993) · Journal of Biological Rhythms · doi:10.1177/074873049300800106 · Cited by 302 · see citing works
Self-citationHelfrich‐Förster, C. (1998) · Journal of Comparative Physiology A · doi:10.1007/s003590050192 · Cited by 298 · see citing works
The Regulation of Circadian Period by Phototransduction Pathways in Arabidopsis
Millar, A. J., Straume, M., Chory, J., et al. (1995) · Science · doi:10.1126/science.7855596 · Cited by 280 · see citing works
Positional Cloning and Sequence Analysis of the Drosophila Clock Gene, timeless
Myers, M. P., Wager‐Smith, K., Wesley, C. S., Young, M. W., & Sehgal, A. (1995) · Science · doi:10.1126/science.270.5237.805 · Cited by 270 · see citing works
Self-citationPost‐transcriptional regulation contributes to Drosophila clock gene mRNA cycling
So, W. V., & Rosbash, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.7146 · Cited by 258 · see citing works
Self-citationKaneko, M. A. N., Helfrich‐Förster, C., & Hall, J. C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06745.1997 · Cited by 256 · see citing works
Self-citationExtraocular Circadian Phototransduction in Humans
Campbell, S. S., & Murphy, P. (1998) · Science · doi:10.1126/science.279.5349.396 · Cited by 246 · see citing works
The biology of vision of Drosophila.
Zuker, C. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.571 · Cited by 198 · see citing works
THE MOLECULAR CONTROL OF CIRCADIAN BEHAVIORAL RHYTHMS AND THEIR ENTRAINMENT IN DROSOPHILA
Young, M. W. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.135 · Cited by 181 · see citing works
Novel Features of Drosophila period Transcription Revealed by Real-Time Luciferase Reporting
Brandes, C., Plautz, J. D., Stanewsky, R., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80088-4 · Cited by 175 · see citing works
Self-citationHamblen, M. J., Zehring, W. A., Kyriacou, C. P., et al. (1986) · Journal of Neurogenetics · doi:10.3109/01677068609106855 · Cited by 170 · see citing works
Hamblen, M. J., Wheeler, D. A., Rutila, J. E., Rosbash, M., & Hall, J. C. (1992) · Journal of Insect Behavior · doi:10.1007/bf01058189 · Cited by 167 · see citing works
Self-citationMolecular Evolution of the Photolyase–Blue-Light Photoreceptor Family
Kanai, S., Kikuno, R., Toh, H., Ryo, H., & Todo, T. (1997) · Journal of Molecular Evolution · doi:10.1007/pl00006258 · Cited by 158 · see citing works
Multiple circadian‐regulated elements contribute to cycling period gene expression in Drosophila
Stanewsky, R., Jamison, C. F., Plautz, J. D., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.16.5006 · Cited by 155 · see citing works
Self-citationMolecular, Biochemical, and Electrophysiological Characterization of Drosophila norpA Mutants
Pearn, M. T., Randall, L. L., Shortridge, R. D., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4937 · Cited by 154 · see citing works
Does Drosophila have seven eyes?
Hofbauer, A., & Buchner, E. (1989) · Naturwissenschaften · doi:10.1007/bf00368438 · Cited by 151 · see citing works
Shedding Light on the Biological Clock
Foster, F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80464-x · Cited by 148 · see citing works
Suri, V., Qian, Z., Hall, J. C., & Rosbash, M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80529-2 · Cited by 148 · see citing works
Self-citationYang, Z., Emerson, M. M., Su, H. S., & Sehgal, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80528-0 · Cited by 123 · see citing works
Stanewsky, R., Frisch, B., Brandes, C., et al. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00676.1997 · Cited by 123 · see citing works
Self-citationAction Spectra for Phase Shifts of a Circadian Rhythm in Drosophila
Frank, K. D., & Zimmerman, W. F. (1969) · Science · doi:10.1126/science.163.3868.688 · Cited by 117 · see citing works
Photosensitivity of the Circadian Rhythm and of Visual Receptors in Carotenoid-DepletedDrosophila
Zimmerman, W. F., & Goldsmith, T. H. (1971) · Science · doi:10.1126/science.171.3976.1167 · Cited by 115 · see citing works
Saunders, D. S., Gillanders, S. W., & Lewis, R. D. (1994) · Journal of Insect Physiology · doi:10.1016/0022-1910(94)90134-1 · Cited by 79 · see citing works
Zhao, S., & Sancar, A. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03214.x · Cited by 78 · see citing works
Hamblen-Coyle, M. J., Konopka, R. J., Zwiebel, L. J., et al. (1989) · Journal of Neurogenetics · doi:10.3109/01677068909066210 · Cited by 76 · see citing works
Neural substrates of Drosophila rhythms revealed by mutants and molecular manipulations
Kaneko, M. A. N. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80095-0 · Cited by 70 · see citing works
Self-citationMa, Y. J., Dissen, G. A., Rage, F., & Ojeda, S. R. (1996) · Methods · doi:10.1006/meth.1996.0102 · Cited by 66 · see citing works
Extraretinal photoreception in entrainment and photoperiodism in invertebrates
Page, T. L. (1982) · Cellular and Molecular Life Sciences · doi:10.1007/bf01955344 · Cited by 65 · see citing works
Conceptual translation of timeless reveals alternative initiating methionines in Drosophila
Rosato, E. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.3.455 · Cited by 64 · see citing works
DETAILED ACTION SPECTRUM FOR THE DELAY SHIFT IN PUPAE EMERGENCE OF DROSOPHILA PSEUDOOBSCURA*
Klemm, E., & Ninnemann, H. (1976) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1976.tb06838.x · Cited by 60 · see citing works
Tissue-specific expression of phospholipase C encoded by the norpA gene of Drosophila melanogaster
Zhu, L., McKay, R. R., & Shortridge, R. D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82349-3 · Cited by 59 · see citing works
The tim SL Mutant Affects a Restricted Portion of the Drosophila melanogaster Circadian Cycle
Rutila, J. E., Maltseva, O. N., & Rosbash, M. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000200 · Cited by 44 · see citing works
Self-citationExtraretinal Photoreception and Circadian Systems in Nonmammalian Vertebrates
Yoshikawa, T., & Oishi, T. (1998) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(97)00290-3 · Cited by 40 · see citing works
Decline of circadian photosensitivity associated with retinal degeneration in CBA/J-rd/rd mice
Yoshimura, T., & Ebihara, S. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01122-0 · Cited by 30 · see citing works
Stanewsky, R., Fry, T. A., Reim, I., et al. (1996) · Genetics · doi:10.1093/genetics/143.1.259 · Cited by 30 · see citing works
Self-citationThe cryptochrome family of blue/UV-A photoreceptors
Cashmore, A. R. (1998) · Journal of Plant Research · doi:10.1007/bf02512182 · Cited by 25 · see citing works
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Brainard, G. C., Hanifin, J. P., Greeson, J. M., Byrne, B., Glickman, G., Gerner, E., & Rollag, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06405.2001 · Cited by 1,930 · see citing works
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Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859 · see citing works
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Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621 · see citing works
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Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81014-4 · Cited by 1,617 · see citing works
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Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402 · see citing works
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Buhr, E. D., Yoo, S.-H., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195262 · Cited by 917 · see citing works
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912 · see citing works
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Chaves, I., Pokorny, R., Byrdin, M., Hoang, N., Ritz, T., Brettel, K., Essen, L.-O., van der Horst, G. T. J., Batschauer, A., & Ahmad, M. (2011) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042110-103759 · Cited by 845 · see citing works
Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12114 · Cited by 690 · see citing works
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Sandrelli, F., Tauber, E., Pegoraro, M., Mazzotta, G., Cisotto, P., Landskron, J., Stanewsky, R., Piccin, A., Rosato, E., Zordan, M., et al. (2007) · Science · doi:10.1126/science.1138426 · Cited by 205 · see citing works
Self-citationSelby, C. P., Thompson, C., Schmitz, T. M., Van Gelder, R. N., & Sancar, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.260498597 · Cited by 184 · see citing works
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Fukushiro, M., Takeuchi, T., Takeuchi, Y., Hur, S.-P., Sugama, N., Takemura, A., Kubo, Y., Okano, K., & Okano, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028643 · Cited by 47 · see citing works
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- Authors
- Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S. A., Rosbash, M., & Hall, J. C.
- Affiliations
- U.S. National Science Foundation (US)
- Scripps Research Institute (US)
- Corresponding author
- Hall, Jeffrey C
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 95
- Issue
- 5
- Pages
- 681-692
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2095299680
- Cited by
- 968
- References
- 57
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 22 · 2023: 30 · 2022: 47 · 2021: 24 · 2020: 27 · 2019: 34 · 2018: 30 · 2017: 38 · 2016: 33 · 2015: 28 · 2014: 41 · 2013: 24 · 2012: 32
- FWCI
- 17.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute of Mental Health (MH-51573, R01MH051573)
- National Institute of General Medical Sciences (P01GM033205, GM-33205)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Keywords
- cryptochrome, circadian photoreceptors, blue light receptor, Drosophila circadian clock, period gene, timeless gene, pacemaker neurons
- MeSH terms
- Animals, Behavior, Animal, Circadian Rhythm, Darkness, Drosophila melanogaster, Eye Proteins, Flavoproteins, Light, Neurons, Nuclear Proteins, Open Reading Frames, Photoreceptor Cells, Invertebrate, Insect Proteins, Mutation, Missense, Drosophila Proteins, Receptors, G-Protein-Coupled, Cryptochromes, Period Circadian Proteins
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