The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
A Novel Receptor-Mediated Nuclear Protein Import Pathway
Open accessAbstract
Targeting of most nuclear proteins to the cell nucleus is initiated by interaction between the classical nuclear localization signals (NLSs) contained within them and the importin NLS receptor complex. We have recently delineated a novel 38 amino acid transport signal in the hnRNP A1 protein, termed M9, which confers bidirectional transport across the nuclear envelope. We show here that M9-mediated nuclear import occurs by a novel pathway that is independent of the well-characterized, importin-mediated classical NLS pathway. Additionally, we have identified a specific M9-interacting protein, termed transportin, which binds to wild-type M9 but not to transport-defective M9 mutants. Transportin is a 90 kDa protein, distantly related to importin beta, and we show that it mediates the nuclear import of M9-containing proteins. These findings demonstrate that there are at least two receptor-mediated nuclear protein import pathways. Furthermore, as hnRNP A1 likely participates in mRNA export, it raises the possibility that transportin is a mediator of this process as well.
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Cites
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Self-citationThe GTP-binding protein Ran/TC4 is required for protein import into the nucleus
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Cited by
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
Fornerod, M., Ohno, M., Yoshida, M., & Mattaj, I. W. (1997) · Cell · doi:10.1016/s0092-8674(00)80371-2 · Cited by 2,081
Nucleocytoplasmic transport: the soluble phase
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Fan, X. C., & Steitz, J. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3448 · Cited by 866
Kinetic analysis of translocation through nuclear pore complexes
Ribbeck, K., & Görlich, D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1320 · Cited by 772
Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation
Khokhlatchev, A. V., Canagarajah, B., Wilsbacher, J., Robinson, M., Atkinson, M., Goldsmith, E., & Cobb, M. H. (1998) · Cell · doi:10.1016/s0092-8674(00)81189-7 · Cited by 677
Metadata
- Authors
- Pollard, V. W., Michael, W. M., Nakielny, S., Siomi, M. C., Wang, F., & Dreyfuss, G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 86
- Issue
- 6
- Pages
- 985-994
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2051948296
- Cited by
- 666
- References
- 51
- FWCI
- 27.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pollard, V. W., Michael, W. M., Nakielny, S., Siomi, M. C., Wang, F., & Dreyfuss, G. (1996). A Novel Receptor-Mediated Nuclear Protein Import Pathway. Cell. https://doi.org/10.1016/s0092-8674(00)80173-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
