The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Nucleocytoplasmic Transport
Abstract
Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation requires energy, and for the import process this energy is at least partly consumed by the action of the small guanosine triphosphatase Ran. In the first half of the review, some of the well-established general background information on nucleocytoplasmic transport is discussed. The second half describes recent information on the mechanistic details of nuclear import and export as well as major unresolved issues such as how directionality is conferred on either import or export. The whole review is slanted toward discussion of metazoan cells.
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Cites
Direct observation of kinesin stepping by optical trapping interferometry
Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993) · Nature · doi:10.1038/365721a0 · Cited by 1,910
Distinct functions for the two importin subunits in nuclear protein import
Görlich, D., Vogel, F., Mills, A. D., Hartmann, E., & Laskey, R. A. (1995) · Nature · doi:10.1038/377246a0 · Cited by 474
Self-citationRch1, a protein that specifically interacts with the RAG-1 recombination-activating protein
Cuomo, C. A., Kirch, S. A., Gyuris, J., Brent, R., & Oettinger, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6156 · Cited by 164
Cited by
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
Mahajan, R., Delphin, C., Guan, T., Gerace, L., & Melchior, F. (1997) · Cell · doi:10.1016/s0092-8674(00)81862-0 · Cited by 1,256
Nucleocytoplasmic transport: the soluble phase
Mattaj, I. W., & Englmeier, L. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.265 · Cited by 1,175
Self-citationFan, X. C., & Steitz, J. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3448 · Cited by 866
Stommel, J. M., Marchenko, N. D., Jimenez, G. S., Moll, U. M., Hope, T. J., & Wahl, G. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.6.1660 · Cited by 738
Metadata
- Authors
- Görlich, D., & Mattaj, I. W.
- Venue
- Science
- Published
- 1996-03-15
- Volume
- 271
- Issue
- 5255
- Pages
- 1513-1519
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4211020343
- Cited by
- 1,086
- References
- 3
- FWCI
- 56.28
- Type
- journal article
- Language
- en
- Open access
- closed
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