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Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway
Open accessAbstract
The Hedgehog (HH) signaling proteins control cell fates and patterning during animal development. In Drosophila, HH protein induces the transcription of target genes encoding secondary signals such as DPP and WG proteins by opposing a repressor system. The repressors include Costal2, protein kinase A, and the HH receptor Patched. Like HH, the kinase Fused and the transcription factor Cubitus interruptus (CI) act positively upon targets. Here we show that costal2 encodes a kinesin-related protein that accumulates preferentially in cells capable of responding to HH. COS2 is cytoplasmic and binds microtubules. We find that CI associates with COS2 in a large protein complex, suggesting that COS2 directly controls the activity of CI.
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Cites
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993
Predicting oligomerization states of coiled coils
Woolfson, D. N., & Alber, T. (1995) · Protein Science · doi:10.1002/pro.5560040818 · Cited by 214
Cited by
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634
The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824
Hedgehog signalling in the mouse requires intraflagellar transport proteins
Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L., & Anderson, K. V. (2003) · Nature · doi:10.1038/nature02061 · Cited by 1,425
Mechanisms and functions of Hedgehog signalling across the metazoa
Ingham, P. W., Nakano, Y., & Seger, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2984 · Cited by 605
Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M., & Ishii, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8143 · Cited by 466
Metadata
- Authors
- Sisson, J. C., Ho, K. S., Suyama, K., & Scott, M. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 90
- Issue
- 2
- Pages
- 235-245
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2171802796
- Cited by
- 330
- References
- 2
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sisson, J. C., Ho, K. S., Suyama, K., & Scott, M. P. (1997). Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway. Cell. https://doi.org/10.1016/s0092-8674(00)80332-3
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