Mechanisms and functions of Hedgehog signalling across the metazoa
Abstract
Hedgehog proteins constitute one of a small number of families of secreted signals that have a central role in the development of metazoans. Genetic analyses in flies, fish and mice have uncovered the major components of the pathway that transduces Hedgehog signals, and recent genome sequence projects have provided clues about its evolutionary origins. In this Review we provide an updated overview of the mechanisms and functions of this signalling pathway, highlighting the conserved and divergent features of the pathway, as well as some of the common themes in its deployment that have emerged from recent studies.
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Mice homozygous for SqleSum3Jus die prior to birth at embryonic day E8.5.
“Mice homozygous for SqleSum3Jus die prior to birth at embryonic day (E)8.5, a phenotype consistent with that found in other mice with mutations affecting cholesterol synthesis25”
From A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome (2013) · cites this paper as [25]
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- Authors
- Ingham, P. W., Nakano, Y., & Seger, C.
- Affiliations
- Institute of Molecular and Cell Biology (SG)
- Hyogo Medical University (JP)
- Corresponding author
- Ingham, Philip W.
- ORCID
- Ingham, Philip W.
- Venue
- Nature Reviews Genetics
- Published
- 2011-04-19
- Volume
- 12
- Issue
- 6
- Pages
- 393-406
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1975584335
- Cited by
- 605
- References
- 5
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 17 · 2023: 23 · 2022: 36 · 2021: 27 · 2020: 45 · 2019: 50 · 2018: 33 · 2017: 41 · 2016: 41 · 2015: 38 · 2014: 68 · 2013: 66 · 2012: 71
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Naito Foundation
- Institute of Molecular and Cell Biology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- Hedgehog signaling, Hedgehog proteins, signal transduction, developmental patterning, evolutionary conservation, comparative developmental biology, metazoan development
- MeSH terms
- Animals, Cilia, Drosophila melanogaster, Gene Expression Regulation, Humans, Ligands, Lipids, Models, Genetic, Phylogeny, Transcription Factors, Signal Transduction, Genome, Protein Structure, Tertiary, Mice, Hedgehog Proteins
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