The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA Repair
Open accessAbstract
Ubiquitin-conjugating enzyme variant (UEV) proteins resemble ubiquitin-conjugating enzymes (E2s) but lack the defining E2 active-site residue. The MMS2-encoded UEV protein has been genetically implicated in error-free postreplicative DNA repair in Saccharomyces cerevisiae. We show that Mms2p forms a specific heteromeric complex with the UBC13-encoded E2 and is required for the Ubc13p-dependent assembly of polyubiquitin chains linked through lysine 63. A ubc13 yeast strain is UV sensitive, and single, double, and triple mutants of the UBC13, MMS2, and ubiquitin (ubiK63R) genes display a comparable phenotype. These findings support a model in which an Mms2p/Ubc13p complex assembles novel polyubiquitin chains for signaling in DNA repair, and they suggest that UEV proteins may act to increase diversity and selectivity in ubiquitin conjugation.
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Cited by
Mechanisms Underlying Ubiquitination
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Self-citationRING Domain E3 Ubiquitin Ligases
Deshaies, R. J., & Joazeiro, C. A. P. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.101807.093809 · Cited by 2,679
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
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Self-citationReceptor downregulation and multivesicular-body sorting
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Metadata
- Authors
- Hofmann, R. M., & Pickart, C. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 96
- Issue
- 5
- Pages
- 645-653
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1988617344
- Cited by
- 819
- References
- 54
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hofmann, R. M., & Pickart, C. M. (1999). Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA Repair. Cell. https://doi.org/10.1016/s0092-8674(00)80575-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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