Receptor downregulation and multivesicular-body sorting
Abstract
The sorting of proteins into the inner vesicles of multivesicular bodies is required for many key cellular processes, which range from the downregulation of activated signalling receptors to the proper stimulation of the immune response. Recent advances in our understanding of the multivesicular-body sorting pathway have resulted from the identification of ubiquitin as a signal for the efficient sorting of proteins into this transport route, and from the discovery of components of the sorting and regulatory machinery that directs this complex process.
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ILV formation requires two distinct processes: organization of the endosome membrane into tetraspanin-enriched microdomains (TEMs) and ESCRT complexes.
“Work in yeast [28-31] and other tissue culture models [32-34] suggests that ILV formation requires two distinct processes. The first involves the organization of the endosome membrane into specialized units highly enriched for a class of membrane proteins called tetraspanins [35].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [33]
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- Authors
- Katzmann, D. J., Odorizzi, G., & Emr, S. D.
- Affiliations
- Mayo Clinic (US)
- University of Colorado Boulder (US)
- Howard Hughes Medical Institute (US)
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2002-12
- Volume
- 3
- Issue
- 12
- Pages
- 893-905
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2019987740
- Cited by
- 1,201
- References
- 0
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 14 · 2023: 11 · 2022: 22 · 2021: 29 · 2020: 20 · 2019: 22 · 2018: 22 · 2017: 23 · 2016: 29 · 2015: 27 · 2014: 35 · 2013: 41 · 2012: 53
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- multivesicular bodies, receptor down-regulation, protein sorting, ubiquitin, endosomal sorting, immune response, endocytosis
- MeSH terms
- Animals, Carrier Proteins, Epidermal Growth Factor, Humans, Membrane Proteins, Models, Biological, Phospholipids, Receptors, Cell Surface, Endosomes, Yeasts, Signal Transduction, Down-Regulation, Protein Structure, Tertiary, Protein Transport, Cytoplasmic Vesicles, Ubiquitin, Saccharomyces cerevisiae Proteins, Vesicular Transport Proteins, Receptors, Notch, Endosomal Sorting Complexes Required for Transport
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