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New Roles for Src Kinases in Control of Cell Survival and Angiogenesis
Open accessAbstract
Src was initially discovered as the oncogenic protein (v-Src) of the retrovirus Rous sarcoma virus. A ubiquitously expressed and highly conserved cellular homolog of v-Src was subsequently discovered. Much of the original research on v-Src and its cellular homolog (Src) paved the way for our current understanding of how oncogenes cause cell transformation. The Src family of nonreceptor protein tyrosine kinases, including Src, Lyn, Fyn, Lck, Hck, Fgr, Blk, and Yes, have important roles in receptor signaling and cellular communication (reviewed in Thomas and Brugge 1997). While most Src kinases are broadly expressed (i.e., Src, Fyn, Yes), certain members of the family such as Hck, Blk, or Lck exhibit a restricted tissue expression.
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Metadata
- Authors
- Schlessinger, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 100
- Issue
- 3
- Pages
- 293-296
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2030413647
- Cited by
- 300
- References
- 0
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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