The DOI matches its Crossref record; 316 of the 316 references it cites were found in a registry or an index.
Blood-brain barrier tight junction permeability and ischemic stroke
Open accessAbstract
The blood-brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels, providing a dynamic interface between the peripheral circulation and the central nervous system. The tight junctions (TJs) between the endothelial cells serve to restrict blood-borne substances from entering the brain. Under ischemic stroke conditions decreased BBB TJ integrity results in increased paracellular permeability, directly contributing to cerebral vasogenic edema, hemorrhagic transformation, and increased mortality. This loss of TJ integrity occurs in a phasic manner, which is contingent on several interdependent mechanisms (ionic dysregulation, inflammation, oxidative and nitrosative stress, enzymatic activity, and angiogenesis). Understanding the inter-relation of these mechanisms is critical for the development of new therapies. This review focuses on those aspects of ischemic stroke impacting BBB TJ integrity and the principle regulatory pathways, respective to the phases of paracellular permeability.
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Cites
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Cited by
The blood-brain barrier in systemic inflammation
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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy
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“Delivery through the permeable BBB under disease conditions Potential to cross the BBB Limited knowledge about dynamic changes in the BBB and their mechanisms [63], [70-72], [75-76],”
BackgroundNeuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
Yang, C., Hawkins, K. E., Doré, S., & Candelario-Jalil, E. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00136.2018 · Cited by 871
Crossing the blood-brain barrier with nanoparticles
Zhou, Y., Peng, Z., Seven, E. S., & Leblanc, R. M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.015 · Cited by 837
Metadata
- Authors
- Sandoval, K. E., & Witt, K. A.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 32
- Issue
- 2
- Pages
- 200-219
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2000351290
- Cited by
- 964
- References
- 316
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
