Non-genomic actions of androgens

Foradori, C.D.; Weiser, M.J.; Handa, R.J.

doi:10.1016/j.yfrne.2007.10.005

Cited by 493Estrogen and related hormone effectsSexual Differentiation and DisordersHormonal and reproductive studies

Non-genomic actions of androgens

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Foradori, C.D., Weiser, M.J., Handa, R.J.·2008·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2007.10.005PMC PMC2386261

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Abstract

Previous work in the endocrine and neuroendocrine fields has viewed the androgen receptor (AR) as a transcription factor activated by testosterone or one of its many metabolites. The bound AR acts as transcription regulatory element by binding to specific DNA response elements in target gene promoters, causing activation or repression of transcription and subsequently protein synthesis. Over the past two decades evidence at the cellular and organismal level has accumulated to implicate rapid responses to androgens, dependent or independent of the AR. Androgen's rapid time course of action; its effects in the absence or inhibition of the cellular machinery necessary for transcription/translation; and in the absence of translocation to the nucleus suggest a method of androgen action not initially dependent on genomic mechanisms (i.e. non-genomic in nature). In the present paper, the non-genomic effects of androgens are reviewed, along with a discussion of the possible role non-genomic androgen actions have on animal physiology and behavior.

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Genomic and non-genomic effects, androgen receptor polymorphism, and intracellular steroid metabolism further contribute to the diversity of the time-course of testosterone effects.
“Genomic and non-genomic effects, androgen receptor polymorphism and intracellular steroid metabolism further contribute to such diversity.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [6]
Canonical and non-canonical AR, ER, and PR are expressed on neuronal membranes and in glial cells.
“Canonical and non-canonical AR, ER, and PR, are expressed on neuronal membranes and in glial cells(Almey et al., 2014; Brinton et al., 2008; Foradori et al., 2008; Mermelstein and Micevych, 2008; Petersen et al., 2013).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Foradori et al., 2008

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Authors: Foradori, C. D., Weiser, M. J., & Handa, R. J.
Affiliations: Colorado State University (US)
Corresponding author: Handa, R.J.
ORCID: Foradori, C.D.
Weiser, M.J.
Handa, R.J.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2008-05
Volume: 29
Issue: 2
Pages: 169-181
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2007.10.005
PMC: PMC2386261
OpenAlex: W1990367576
Cited by: 493
References: 179
Citations by year: 2026: 15 · 2025: 12 · 2024: 22 · 2023: 21 · 2022: 31 · 2021: 26 · 2020: 36 · 2019: 27 · 2018: 37 · 2017: 30 · 2016: 35 · 2015: 28 · 2014: 29 · 2013: 32 · 2012: 23
FWCI: 1.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Lalor Foundation
National Institutes of Health (1f32ns049892-01a1)
U.S. Public Health Service
National Institute of Neurological Disorders and Stroke (1 R01 NS033951, 5F32NS049892, R01NS039951, F32 NS049892)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: androgen receptor, androgens, testosterone, steroid hormone signaling, animal physiology, animal behavior
MeSH terms: Androgens, Animals, Cell Membrane, Gonadotropin-Releasing Hormone, Membrane Fluidity, Receptors, Androgen, Sexual Behavior, Animal, Dihydrotestosterone, Testosterone, Time Factors, Second Messenger Systems, Genome, Calcium Signaling

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