The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Novel Mechanism of TRAF Signaling Revealed by Structural and Functional Analyses of the TRADD–TRAF2 Interaction
Open accessAbstract
TRAF proteins are major mediators for the cell activation, cell survival, and antiapoptotic functions of the TNF receptor superfamily. They can be recruited to activated TNF receptors either by direct interactions with the receptors or indirectly via the adaptor protein TRADD. We now report the structure of the TRADD-TRAF2 complex, which is highly distinct from receptor-TRAF2 interactions. This interaction is significantly stronger and we show by an in vivo signaling assay that TRAF2 signaling is more readily initiated by TRADD than by direct receptor-TRAF2 interactions. TRADD is specific for TRAF1 and TRAF2, which ensures the recruitment of clAPs for the direct inhibition of caspase activation in the signaling complex. The stronger affinity and unique specificity of the TRADD-TRAF2 interaction are crucial for the suppression of apoptosis and provide a mechanistic basis for the perturbation of TRAF recruitment in sensitizing cell death induction.
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Cites
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677
TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex
Hsu, H., Huang, J., Shu, H.-B., Baichwal, V., & Goeddel, D. V. (1996) · Immunity · doi:10.1016/s1074-7613(00)80252-6 · Cited by 1,182
Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors
Myszka, D. G. (1997) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(97)80157-7 · Cited by 552
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Brenner, D., Blaser, H., & Mak, T. W. (2015) · Nature Reviews Immunology · doi:10.1038/nri3834 · Cited by 998
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Napetschnig, J., & Wu, H. (2013) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-083012-130338 · Cited by 933
Self-citationChung, J. Y., Park, Y. C., Ye, H., & Wu, H. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.4.679 · Cited by 613
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Metadata
- Authors
- Park, Y. C., Ye, H., Hsia, C., Segal, D., Rich, R. L., Liou, H.-C., Myszka, D. G., & Wu, H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 101
- Issue
- 7
- Pages
- 777-787
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2071981344
- Cited by
- 190
- References
- 5
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Park, Y. C., Ye, H., Hsia, C., Segal, D., Rich, R. L., Liou, H.-C., Myszka, D. G., & Wu, H. (2000). A Novel Mechanism of TRAF Signaling Revealed by Structural and Functional Analyses of the TRADD–TRAF2 Interaction. Cell. https://doi.org/10.1016/s0092-8674(00)80889-2
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