The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival
Open accessAbstract
Transcriptional regulation by the glucocorticoid receptor (GR) is essential for survival. Since the GR can influence transcription both through DNA-binding-dependent and -independent mechanisms, we attempted to assess their relative importance in vivo. In order to separate these modes of action, we introduced the point mutation A458T into the GR by gene targeting using the Cre/loxP system. This mutation impairs dimerization and therefore GRE-dependent transactivation while functions that require cross-talk with other transcription factors, such as transrepression of AP-1-driven genes, remain intact. In contrast to GR-/- mice, these mutants termed GRdim are viable, revealing the in vivo relevance of DNA-binding-independent activities of the GR.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Contrastingly, other findings indicate that in GRdim mice NF-κB and AP-1 target genes can still be silenced by GCs (107, 108), that the GC-inducible gene MKP-1 is normally expressed in macrophages (82) and that irritant dermatitis can successfully be treated with GCs (22).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [107]
In the citing paper
“Initial evidence suggested that classic transactivation by GRs was defective in these mice and that this mechanism was required for the full range of GC immunosuppressive actions (107, 108).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [107]
Citations
Cites
Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., & Riccardi, C. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90198-o · Cited by 4,562
Angel, P. E., Imagawa, M., Chiu, R., Stein, B., Imbra, R. J., Rahmsdorf, H. J., Jonat, C., Herrlich, P. A., & Karin, M. (1987) · Cell · doi:10.1016/0092-8674(87)90611-8 · Cited by 2,930
Self-citationTodaro, G. J., & Green, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.299 · Cited by 2,747
Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science · doi:10.1126/science.270.5234.286 · Cited by 2,390
Steroid hormone receptors: Many Actors in search of a plot
Beato, M., Herrlich, P. A., & Schütz, G. (1995) · Cell · doi:10.1016/0092-8674(95)90201-5 · Cited by 1,816
Self-citationRole of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., & Baldwin, A. S. (1995) · Science · doi:10.1126/science.270.5234.283 · Cited by 1,676
Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553
Jonat, C., Rahmsdorf, H. J., Park, K.-K., Cato, A. C. B., Gebel, S., Ponta, H., & Herrlich, P. (1990) · Cell · doi:10.1016/0092-8674(90)90395-u · Cited by 1,544
Self-citationCrystallographic analysis of the interaction of the glucocorticoid receptor with DNA
Luisi, B. F., Xu, W. X., Otwinowski, Z., Freedman, L. P., Yamamoto, K. R., & Sigler, P. B. (1991) · Nature · doi:10.1038/352497a0 · Cited by 1,503
Diamond, M. I., Miner, J. N., Yoshinaga, S. K., & Yamamoto, K. R. (1990) · Science · doi:10.1126/science.2119054 · Cited by 1,274
Research works printed but not linked: 3
- Caldenhoven, 1995, Negative cross-talk between RelA and the glucocorticoid receptor, Mol. Endocrinol., 9, 401
- Chang, 1993, Inhibition of mouse GATA-1 function by the glucocorticoid receptor, Mol. Endocrinol., 7, 528
- Miner, 1991, Joints in the regulatory lattice, Cell Growth Differ., 2, 525
Cited by
Sorted by citations
Items 101–200 of 996
Glucocorticoid receptor variants: clinical implications
DeRijk, R. H., Schaaf, M. J. M., & de Kloet, E. R. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00062-6 · Cited by 256
Perspectives on glucocorticoid-induced osteoporosis
CANALIS, E. M., Bilezikian, J. P., Angeli, A., & Giustina, A. (2003) · Bone · doi:10.1016/j.bone.2003.11.026 · Cited by 244
Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability
Wei, Q., Lu, X., Liu, L., Schafer, G. L., Shieh, K.-R., Burke, S., Robinson, T. E., Watson, S. J., Seasholtz, A. F., & Akil, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402208101 · Cited by 260
Hartmann, K., Koenen, M., Schauer, S., Wittig-Blaich, S., Ahmad, M., Baschant, U., & Tuckermann, J. P. (2016) · Physiological Reviews · doi:10.1152/physrev.00011.2015 · Cited by 251
Self-citationLindern, M. V., Zauner, W., Mellitzer, G., Steinlein, P., Fritsch, G., Huber, K. R., Löwenberg, B., & Beug, H. (1999) · Blood · doi:10.1182/blood.v94.2.550 · Cited by 248
Cross-talk between nuclear receptors and nuclear factor κB
Bosscher, K. D., Berghe, W. V., & Haegeman, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209935 · Cited by 250
Sheppard, K.-A., Phelps, K. M., Williams, A. J., Thanos, D., Glass, C. K., Rosenfeld, M. G., Gerritsen, M. E., & Collins, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29291 · Cited by 305
Bilodeau, S., Vallette-Kasic, S., Gauthier, Y., Figarella‐Branger, D., Brue, T. C., Berthelet, F., Lacroix, A., Batista, D. L., Stratakis, C. A., Hanson, J., et al. (2006) · Genes & Development · doi:10.1101/gad.1444606 · Cited by 249
Genomic and epigenomic mechanisms of glucocorticoids in the brain
Gray, J. D., Kogan, J. F., Marrocco, J., & McEwen, B. S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.97 · Cited by 242
An affective disorder in zebrafish with mutation of the glucocorticoid receptor
Ziv, L., Muto, A., Schoonheim, P. J., Meijsing, S. H., Strasser, D., Ingraham, H. A., Schaaf, M. J. M., Yamamoto, K. R., & Baier, H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.64 · Cited by 242
Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor
Rogatsky, I., Wang, J.-C., Derynck, M. K., Nonaka, D. F., Khodabakhsh, D. B., Haqq, C. M., Darimont, B. D., Garabedian, M. J., & Yamamoto, K. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336092100 · Cited by 242
Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice
Marwick, J. A., Caramori, G., Stevenson, C. S., Casolari, P., Jazrawi, E., Barnes, P. J., Ito, K., Adcock, I. M., Kirkham, P., & Papi, A. A. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1570oc · Cited by 236
Glucocorticoid receptor physiology
Heitzer, M. D., Wolf, I. M., Sánchez, E. R., Witchel, S. F., & DeFranco, D. B. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9059-8 · Cited by 235
Cross-talk between glucocorticoid receptor and AP-1
Herrlich, P. A. (2001) · Oncogene · doi:10.1038/sj.onc.1204388 · Cited by 229
Self-citationProgesterone receptors, their isoforms and progesterone regulated transcription
Jacobsen, B. M., & Horwitz, K. B. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.016 · Cited by 229
Nuclear receptors versus inflammation: mechanisms of transrepression
Pascual, G., & Glass, C. K. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.08.005 · Cited by 225
Pfitzner, E., Jähne, R., Wissler, M., Stoecklin, E., & Groner, B. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.10.0180 · Cited by 233
Tuckermann, J. P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B. E., Stride, B. D., Förster, I., Habenicht, A. J. R., et al. (2007) · HAL · Cited by 224
Self-citationSchäcke, H., Berger, M., Rehwinkel, H., & Asadullah, K. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.014 · Cited by 223
Brain mineralocorticoid receptors and centrally regulated functions
de Kloet, E. R., van Acker, S. A. B. E., Sibug, R. M., Oitzl, M. S., Meijer, O. C., Rahmouni, K., & de Jong, W. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00971.x · Cited by 218
Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds
Sundahl, N., Bridelance, J., Libert, C., Bosscher, K. D., & Beck, I. M. E. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.05.001 · Cited by 220
Glucocorticoids exert opposing effects on macrophage function dependent on their concentration
Lim, H., Müller, N., Herold, M. J., van den Brandt, J., & Reichardt, H. M. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02611.x · Cited by 218
Self-citationThe clinical use of corticosteroids in pregnancy
Kemp, M. W., Newnham, J. P., Challis, J. R. G., Jobe, A., & Stock, S. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv047 · Cited by 224
Interactions between GH, IGF-I, Glucocorticoids, and Thyroid Hormones during Skeletal Growth
Robson, H., Siebler, T., Shalet, S. M., & Williams, G. R. (2002) · Pediatric Research · doi:10.1203/00006450-200208000-00003 · Cited by 215
Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad ?
Pofi, R., Caratti, G., Ray, D. W., & Tomlinson, J. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad016 · Cited by 237
Strickland, I., Kisich, K. O., Hauk, P. J., Vottero, A., Chrousos, G. P., Klemm, D. J., & Leung, D. Y. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.5.585 · Cited by 215
Enhancer Activation Requires trans-Recruitment of a Mega Transcription Factor Complex
Liu, Z., Merkurjev, D., Yang, F., Li, W., Oh, S., Friedman, M. J., Song, X., Zhang, F., Ma, Q., Ohgi, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.027 · Cited by 221
Lung Development and Function in Preterm Infants in the Surfactant Treatment Era
Jobe, A. H., & Ikegami, M. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.825 · Cited by 214
Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor
Clark, A. R., & Belvisi, M. G. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.12.004 · Cited by 209
Signaling and Transcriptional Mechanisms in Pituitary Development
Dasen, J. S., & Rosenfeld, M. G. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.327 · Cited by 208
Beischlag, T. V., & Perdew, G. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500090200 · Cited by 203
MOLECULAR MECHANISMS OF GLUCOCORTICOIDS IN THE CONTROL OF INFLAMMATION AND LYMPHOCYTE APOPTOSIS
Tuckermann, J. P., Kleiman, A., McPherson, K., & Reichardt, H. M. (2004) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360590888983 · Cited by 203
Self-citationReichardt, H. M., Umland, T., Bauer, A., Kretz, O., & Schütz, G. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.9009-9017.2000 · Cited by 206
Self-citationNewton, R. C., Seybold, J., Kuitert, L. M. E., Bergmann, M., & Barnes, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.32312 · Cited by 197
Charmandari, E., Kino, T., Ichijo, T., & Chrousos, G. P. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0040 · Cited by 201
Glidewell-Kenney, C., Hurley, L., Pfaff, L. E., Weiss, J., Levine, J. E., & Jameson, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611514104 · Cited by 200
Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas.
Herr, I., Ucur, E., Herzer, K., Okouoyo, S., Ridder, R., Krammer, P. H., Doeberitz, M. V. K., & Debatin, K. (2003) · PubMed · Cited by 196
Tuckermann, J. P., Reichardt, H. M., Arribas, R., Richter, K. H., Schütz, G., & Angel, P. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.7.1365 · Cited by 196
Self-citationWatts, A. B. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.09.001 · Cited by 200
Webster, J., & Sternberg, E. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1810207 · Cited by 196
Corticosteroid Actions in the Hippocampus
Joëls, M. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00688.x · Cited by 196
Role of Transcription Factors in Fetal Lung Development and Surfactant Protein Gene Expression
Mendelson, C. R. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.875 · Cited by 193
Heier, C. R., Damsker, J. M., Yu, Q., Dillingham, B. C., Huynh, T., van der Meulen, J. H., Sali, A., Miller, B. K., Phadke, A., Scheffer, L., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302621 · Cited by 191
Limbourg, F. P., Huang, Z., Plumier, J.-C., Simoncini, T., Fujioka, M., Tuckermann, J. P., Schütz, G., Moskowitz, M. A., & Liao, J. K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15481 · Cited by 221
Self-citationTranscriptional Control of Wound Repair
Schäfer, M., & Werner, S. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123609 · Cited by 190
Belvisi, M. G., Wicks, S., Battram, C. H., Bottoms, S. E., Redford, J., Woodman, P., Brown, T. J., Webber, S. E., & Foster, M. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1975 · Cited by 184
Redox-dependent Regulation of Nuclear Import of the Glucocorticoid Receptor
Okamoto, K., Tanaka, H., Ogawa, H., Makino, Y., Eguchi, H., Hayashi, S.-I., Yoshikawa, N., Poellinger, L., Umesono, K., & Makino, I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10363 · Cited by 184
Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells
Liberman, A. C., Budziñski, M. L., Sokn, C., Gobbini, R. P., Steininger, A., & ARZT, E. S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00235 · Cited by 190
The Search for Safer Glucocorticoid Receptor Ligands
Rosen, J., & Miner, J. N. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0002 · Cited by 187
Hypothalamic‐Pituitary‐Adrenal (HPA) Axis and Aging
Gupta, D., & Morley, J. E. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130049 · Cited by 210
Bland, M. L., Jamieson, C., Akana, S. F., Bornstein, S. R., Eisenhofer, G., Dallman, M. F., & Ingraham, H. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14488 · Cited by 181
Leberbauer, C., Boulmé, F., Unfried, G., Huber, J. C., Beug, H., & Müllner, E. W. (2004) · Blood · doi:10.1182/blood-2004-03-1002 · Cited by 180
Genetic dissection of glucocorticoid receptor function in mice
Tronche, F., Kellendonk, C., Reichardt, H. M., & Schütz, G. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80007-5 · Cited by 177
Self-citationKino, T., Su, Y. A., & Chrousos, G. P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0098-z · Cited by 179
Corticosteroid-insensitive asthma: molecular mechanisms
Adcock, I. M., & Lane, S. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780347 · Cited by 179
GPCRs: Emerging anti-cancer drug targets
Nieto, A., & McDonald, P. H. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.09.005 · Cited by 173
Ubc9 Interacts with the Androgen Receptor and Activates Receptor-dependent Transcription
Poukka, H., Aarnisalo, P., Karvonen, U., Palvimo, J. J., & Jänne, O. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19441 · Cited by 174
The Hop2 Protein Has a Direct Role in Promoting Interhomolog Interactions during Mouse Meiosis
Petukhova, G. V., Romanienko, P. J., & Camerini‐Otero, R. D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00369-1 · Cited by 168
Song, C.-Z., Tian, X., & GELEHRTER, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11776 · Cited by 172
HIF1α synergizes with glucocorticoids to promote BFU-E progenitor self-renewal
Flygare, J., Rayon-Estrada, V., Shin, C., Gupta, S., & Lodish, H. F. (2010) · Blood · doi:10.1182/blood-2010-07-295550 · Cited by 168
The Role of Glucocorticoids in Inflammatory Diseases
Reichardt, S. D., Amouret, A., Muzzi, C., Vettorazzi, S., Tuckermann, J. P., Lühder, F., & Reichardt, H. M. (2021) · Cells · doi:10.3390/cells10112921 · Cited by 191
Self-citationCorticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
Karst, H., Karten, Y. J. G., Reichardt, H. M., de Kloet, E. R., Schütz, G., & Joëls, M. (2000) · Nature Neuroscience · doi:10.1038/79910 · Cited by 171
Self-citationRapid engineering of bacterial artificial chromosomes using oligonucleotides
Swaminathan, S., Ellis, H. M., Waters, L. S., Yu, D., Lee, E.-C., Court, D. L., & Sharan, S. K. (2000) · genesis · doi:10.1002/1526-968x(200101)29:1 · Cited by 154
General Molecular Biology and Architecture of Nuclear Receptors
Pawlak, M., Lefèbvre, P., & Staels, B. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612799436641 · Cited by 192
Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia
Tissing, W. J. E., Meijerink, J. P. P., den Boer, M. L., & Pieters, R. (2003) · Leukemia · doi:10.1038/sj.leu.2402733 · Cited by 166
Amsterdam, A., Tajima, K., & Sasson, R. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01147-4 · Cited by 167
AP-1--glucocorticoid receptor crosstalk taken to a higher level
Karin, M., & Chang, L. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690447 · Cited by 167
Kleiman, A., & Tuckermann, J. P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.009 · Cited by 165
Self-citationGlucocorticoid and Androgen Activation of Monoamine Oxidase A Is Regulated Differently by R1 and Sp1
Ou, X., Chen, K., & Shih, J. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600250200 · Cited by 165
New insights into the cell- and tissue-specificity of glucocorticoid actions
Quatrini, L., & Ugolini, S. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00526-2 · Cited by 174
A transcription factor party during blood cell differentiation
Sieweke, M. H., & Graf, T. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80009-9 · Cited by 164
Molecular Identification and Characterization of A and B Forms of the Glucocorticoid Receptor
Yudt, M. R., & Cidlowski, J. A. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.7.0667 · Cited by 164
Ruiz, M., Lind, U., Gåfvels, M. E., Eggertsen, G., Carlstedt‐Duke, J., Nilsson, L., Holtmann, M. H., Stierna, P., Wikström, A., & Werner, S. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01323.x · Cited by 164
Glucocorticoid-regulated Transcription Factors
Adcock, I. M. (2001) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.2001.0283 · Cited by 163
Central corticosteroid actions: Search for gene targets
Datson, N. A., Morsink, M. C., Meijer, O. C., & de Kloet, E. R. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.070 · Cited by 171
Porcher, C., Liao, E. C.-W., Fujiwara, Y., Zon, L. I., & Orkin, S. H. (1999) · Development · doi:10.1242/dev.126.20.4603 · Cited by 161
Glucocorticoids: Effects on Gene Transcription
Adcock, I. M., Ito, K., & Barnes, P. J. (2004) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200402-001ms · Cited by 160
New ideas about aldosterone signaling in epithelia
Stockand, J. D. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00320.2001 · Cited by 158
Nuclear receptors, mitochondria and lipid metabolism
Alaynick, W. A. (2008) · Mitochondrion · doi:10.1016/j.mito.2008.02.001 · Cited by 163
Molecular Mechanisms of Glucocorticosteroid Actions
Adcock, I. M. (2000) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.2000.0243 · Cited by 161
Kolbus, A., Herr, I., Schreiber, M., Debatin, K., Wagner, E. F., & Angel, P. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.575-582.2000 · Cited by 156
Self-citationLim, H., Uhlenhaut, N. H., Rauch, A., Weiner, J., Hübner, S., Hübner, N., Won, K., Lazar, M. A., Tuckermann, J. P., & Steger, D. J. (2015) · Genome Research · doi:10.1101/gr.188581.114 · Cited by 156
Self-citationNew Insights in Glucocorticoid Receptor Signaling—More Than Just a Ligand-Binding Receptor
Scheschowitsch, K., Leite, J. A., & Assreuy, J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00016 · Cited by 164
Mifsud, K. R., & Reul, J. M. H. M. (2018) · Stress · doi:10.1080/10253890.2018.1456526 · Cited by 172
Vettorazzi, S., Bode, C., Dejager, L., Frappart, L., Shelest, E., Klaßen, C., Tasdogan, A., Reichardt, H. M., Libert, C., Schneider, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms8796 · Cited by 158
Self-citationKleiman, A., Hübner, S., Parkitna, J. M. R., Neumann, A., Hofer, S., Weigand, M. A., Bauer, M., Schmid, W., Schütz, G., Libert, C., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-192112 · Cited by 152
Self-citationThe Nuclear Receptor Superfamily and Drug Discovery
Moore, J. T., Collins, J. L., & Pearce, K. H. (2006) · ChemMedChem · doi:10.1002/cmdc.200600006 · Cited by 152
Mechanisms of Glucocorticoid-receptor-mediated Repression of Gene Expression
Webster, J. C., & Cidlowski, J. A. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(99)00186-1 · Cited by 152
Tissue glucocorticoid resistance/hypersensitivity syndromes
Kino, T., Martino, M. U. D., Charmandari, E., Mirani, M., & Chrousos, G. P. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00218-8 · Cited by 150
Glucocorticoid receptors: finding the middle ground
Desmet, S. J., & Bosscher, K. D. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88886 · Cited by 152
Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia
Schmidt, S. U., Rainer, J., Riml, S., Ploner, C., Jesacher, S., Achmüller, C., Presul, E., Skvortsov, S., Crazzolara, R., Fiegl, M., et al. (2005) · Blood · doi:10.1182/blood-2005-07-2853 · Cited by 149
Glucocorticoid-Induced Osteoporosis
Frenkel, B., White, W., & Tuckermann, J. P. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2895-8_8 · Cited by 154
Self-citationDifferent glucocorticoids vary in their genomic and non‐genomic mechanism of action in A549 cells
Croxtall, J. D., van Hal, P. T. W., Choudhury, Q., Gilroy, D. W., & Flower, R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704474 · Cited by 148
Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword
Gruver-Yates, A., & Cidlowski, J. A. (2013) · Cells · doi:10.3390/cells2020202 · Cited by 146
MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?
Clark, A. R. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780005 · Cited by 148
Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor
Escoter-Torres, L., Caratti, G., Mechtidou, A., Tuckermann, J. P., Uhlenhaut, N. H., & Vettorazzi, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01859 · Cited by 156
Self-citationNotini, A. J., Davey, R. A., McManus, J. F., Bate, K. L., & Zajac, J. D. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01884 · Cited by 145
Wang, Z. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010095 · Cited by 148
Psarra, A. G., Solakidi, S., & Sekeris, C. E. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.025 · Cited by 146
Glucocorticoid-Induced Apoptosis of Healthy and Malignant Lymphocytes
Smith, L. K., & Cidlowski, J. A. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82001-1 · Cited by 147
Metadata
- Authors
- Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., & Schütz, G.
- Affiliations
- German Cancer Research Center (DE)
- Saarland University (DE)
- Corresponding author
- Schütz, Günther
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 93
- Issue
- 4
- Pages
- 531-541
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1997510672
- Cited by
- 1,068
- References
- 54
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 7 · 2023: 16 · 2022: 21 · 2021: 22 · 2020: 21 · 2019: 28 · 2018: 24 · 2017: 26 · 2016: 18 · 2015: 24 · 2014: 40 · 2013: 36 · 2012: 34
- FWCI
- 38.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoid receptor, DNA binding, receptor dimerization, gene targeting, Cre-loxP system, transcriptional regulation, survival
- MeSH terms
- Amino Acid Sequence, Animals, Cells, Cultured, Dexamethasone, DNA, Feedback, Gene Expression Regulation, Glucocorticoids, Hypothalamo-Hypophyseal System, Molecular Sequence Data, Pituitary-Adrenal System, Protein Binding, Receptors, Glucocorticoid, T-Lymphocytes, Transcription, Genetic, Erythroid Precursor Cells, Apoptosis, Point Mutation, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
