Kaestner, Klaus H.

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Dou, Z., Ghosh, K., Vizioli, M. G., Zhu, J., Sen, P., Wangensteen, K. J., Simithy, J., Lan, Y., Lin, Y., Zhou, Z., et al. (2017) · Nature

interferon and immune responsesTelomeres, Telomerase, and Senescence

Cited by 1,335

DNA binding of the glucocorticoid receptor is not essential for survival

Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 1,068

Krüppel-like factor 4 regulates macrophage polarization

Liao, X., Sharma, N., Kapadia, F., Zhou, G., Lu, Y., Hong, H., Paruchuri, K., Mahabeleshwar, G. H., Dalmas, E., Venteclef, N., et al. (2011) · Journal of Clinical Investigation

Kruppel-like factors researchImmune cells in cancer

Cited by 778

KLF Family Members Regulate Intrinsic Axon Regeneration Ability

Moore, D. L., Blackmore, M. G., Hu, Y., Kaestner, K. H., Bixby, J. L., Lemmon, V. P., & Goldberg, J. L. (2009) · Science

Nerve injury and regenerationKruppel-like factors research

Cited by 714

Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis

Parviz, F., Matullo, C., Garrison, W. D., Savatski, L., Adamson, J. W., Ning, G., Kaestner, K. H., Rossi, J. M., Zaret, K. S., & Duncan, S. A. (2003) · Nature Genetics

Liver physiology and pathologyDevelopmental Biology and Gene Regulation

Cited by 588

The initiation of liver development is dependent on Foxa transcription factors

Lee, C. S., Friedman, J. R., Fulmer, J. T., & Kaestner, K. H. (2005) · Nature

Developmental Biology and Gene RegulationLiver physiology and pathology

Cited by 581

Fox transcription factors: from development to disease

Golson, M. L., & Kaestner, K. H. (2016) · Development

Developmental Biology and Gene RegulationFOXO transcription factor regulation

Cited by 406

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

Iwafuchi-Doi, M., Donahue, G., Kakumanu, A., Watts, J. A., Mahony, S., Pugh, B. F., Lee, D., Kaestner, K. H., & Zaret, K. S. (2016) · Molecular Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 390

Expansion of β-cell mass in response to pregnancy

Rieck, S., & Kaestner, K. H. (2010) · Trends in Endocrinology & Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 358

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

Wang, Y. J., Traum, D., Schug, J., Gao, L., Liu, C., Atkinson, M. A., Powers, A. C., Feldman, M. D., Naji, A., Chang, K.-M., et al. (2019) · Cell Metabolism

Diabetes and associated disordersPancreatic function and diabetes

Cited by 228

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function

Avrahami, D., Li, C., Zhang, J., Schug, J., Avrahami, R., Rao, S., Stadler, M. B., Burger, L., Schübeler, D., Glaser, B., et al. (2015) · Cell Metabolism

Epigenetics and DNA MethylationPancreatic function and diabetes

Cited by 207

β-Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

Tan, X., Yuan, Y., Zeng, G., Apte, U., Thompson, M. D., Cieply, B., Stolz, D. B., Michalopoulos, G. K., Kaestner, K. H., & Monga, S. P. S. (2008) · Hepatology

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 202

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice

Oliver-Krasinski, J. M., Kasner, M. T., Yang, J., Crutchlow, M. F., Rustgi, A. K., Kaestner, K. H., & Stoffers, D. A. (2009) · Journal of Clinical Investigation

Pancreatic function and diabetesDevelopmental Biology and Gene Regulation

Cited by 177

Expansion of adult β-cell mass in response to increased metabolic demand is dependent on HNF-4α

Gupta, R. K., Gao, N., Gorski, R. K., White, P., Hardy, O. T., Rafiq, K., Brestelli, J. E., Chen, G., Stoeckert, C. J., & Kaestner, K. H. (2007) · Genes & Development

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 161

The transcriptional response of the islet to pregnancy in mice

Rieck, S., White, P., Schug, J., Fox, A. J., Smirnova, O., Gao, N., Gupta, R. K., Wang, Z. V., Scherer, P. E., Keller, M. P., et al. (2009) · Molecular Endocrinology

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 160

Genome-wide analysis of histone modifications in human pancreatic islets

Bhandare, R., Schug, J., Le Lay, J., Fox, A., Smirnova, O., Liu, C., Naji, A., & Kaestner, K. H. (2010) · Genome Research

Genomics and Chromatin DynamicsPancreatic function and diabetes

Cited by 136

Foxa1 and Foxa2 regulate bile duct development in mice

Li, Z., White, P., Tuteja, G., Rubins, N., Sackett, S., & Kaestner, K. H. (2009) · Journal of Clinical Investigation

Liver physiology and pathologyPediatric Hepatobiliary Diseases and Treatments

Cited by 131

Resetting the transcription factor network reverses terminal chronic hepatic failure

Nishikawa, T., Bell, A., Brooks, J. M., Setoyama, K., Melis, M., Han, B., Fukumitsu, K., Handa, K., Tian, J., Kaestner, K. H., et al. (2015) · Journal of Clinical Investigation

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 124

β-Catenin is critical for early postnatal liver growth

Apte, U., Zeng, G., Thompson, M. D., Muller, P., Micsenyi, A., Cieply, B., Kaestner, K. H., & Monga, S. P. S. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 119

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting

Jiao, Y., Le Lay, J., Yu, M., Naji, A., & Kaestner, K. H. (2014) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 118

Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

Chen, C.-W., Guan, B.-J., Alzahrani, M. R., Gao, Z., Gao, L., Bracey, S., Wu, J., Mbow, C. A., Jobava, R., Haataja, L., et al. (2022) · Nature Communications

Pancreatic function and diabetesEndoplasmic Reticulum Stress and Disease

Cited by 116

Postnatal DNA demethylation and its role in tissue maturation

Reizel, Y., Sabag, O., Skversky, Y., Spiro, A., Steinberg, B., Bernstein, D., Wang, A., Kieckhaefer, J., Li, C., Pikarsky, E., et al. (2018) · Nature Communications

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 83

Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling

Rosenberg, N., Van Haele, M., Lanton, T., Brashi, N., Bromberg, Z., Adler, H., Giladi, H., Peled, A., Goldenberg, D. S., Axelrod, J. H., et al. (2022) · Journal of Hepatology

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 72

Collapse of the hepatic gene regulatory network in the absence of FoxA factors

Reizel, Y., Morgan, A., Gao, L., Lan, Y., Manduchi, E., Waite, E. L., Wang, A. W., Wells, A., & Kaestner, K. H. (2020) · Genes & Development

Genomics and Chromatin DynamicsLiver physiology and pathology

Cited by 60