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SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans

Sieburth, Derek S, Sun, Qun, Han, Min·1998·Cell
DOI 10.1016/s0092-8674(00)81227-1
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Abstract

We describe the identification and characterization of a novel gene, sur-8, that positively regulates Ras-mediated signal transduction during C. elegans vulval development. Reduction of sur-8 function suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations, while increase of sur-8 dosage enhances an activated ras mutation. sur-8 appears to act downstream of or in parallel to ras but upstream of raf. sur-8 encodes a conserved protein that is composed predominantly of leucine-rich repeats. The SUR-8 protein interacts directly with Ras but not with the Ras(P34G) mutant protein, suggesting that SUR-8 may mediate its effects through Ras binding. A structural and functional SUR-8 homolog in humans specifically binds K-Ras and N-Ras but not H-Ras in vitro.

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Research works printed but not linked: 45

  1. Akasaka, 1996, Differential structural requirements for interaction of Ras protein with its distinct downstream effectors, J. Biol. Chem., 271, 5353, 10.1074/jbc.271.10.5353 · DOI · Paper page
  2. Barbacid, 1987, ras genes, Annu. Rev. Biochem., 56, 779, 10.1146/annurev.bi.56.070187.004023 · DOI · Paper page
  3. Beitel, 1990, Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction, Nature, 348, 503, 10.1038/348503a0 · DOI
  4. Beitel, 1995, The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway, Genes Dev., 9, 3149, 10.1101/gad.9.24.3149 · DOI
  5. Bos, 1988, The ras gene family and human carcinogenesis, Cancer Res., 49, 4682
  6. Brenner, 1974, The genetics of Caenorhabditis elegans, Genetics, 71, 71, 10.1093/genetics/77.1.71 · DOI
  7. Chamberlin, 1994, The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans, Development, 120, 2713, 10.1242/dev.120.10.2713 · DOI
  8. Church, 1995, mek-2, mpk-1/sur-1 and let-60 ras are required for meiotic cell cycle progression in Caenohabditis elegans, Development, 121, 2525, 10.1242/dev.121.8.2525 · DOI
  9. Cutler, 1992, Isolation of a novel cDNA capable of suppressing v-Ras transformation, Mol. Cell. Biol., 12, 3750, 10.1128/MCB.12.9.3750 · DOI
  10. Dickson, 1992, Raf functions downstream of Ras1 in the Sevenless signal transduction pathway, Nature, 360, 600, 10.1038/360600a0 · DOI
  11. Ferguson, 1985, Identification and characterization of 22 genes that affect the vulval cell lineages of Caenorhabditis elegans., Genetics, 110, 17, 10.1093/genetics/110.1.17 · DOI
  12. Ferguson, 1987, A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans, Nature, 326, 259, 10.1038/326259a0 · DOI
  13. Field, 1990, Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae, Science, 247, 464, 10.1126/science.2405488 · DOI
  14. Furth, 1987, Expression of ras proto-Oncogene proteins in normal human tissues, Oncogene, 1, 47
  15. Gutch, 1998, The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development, Genes Dev., 12, 571, 10.1101/gad.12.4.571 · DOI
  16. Han, 1990, let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein, Cell, 63, 921, 10.1016/0092-8674(90)90495-Z · DOI
  17. Han, 1990, The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans, Genetics, 126, 899, 10.1093/genetics/126.4.899 · DOI
  18. Han, 1993, C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation, Nature, 363, 133, 10.1038/363133a0 · DOI
  19. Hofsteenge, 1988, Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats, Biochemistry, 27, 8537, 10.1021/bi00423a006 · DOI
  20. Johnson, 1997, K-ras is an essential gene in mouse with partial functional overlap with N-ras, Genes Dev., 11, 2468, 10.1101/gad.11.19.2468 · DOI
  21. Kaelin, 1991, Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product, Cell, 64, 521, 10.1016/0092-8674(91)90236-R · DOI
  22. Kataoka, 1985, DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase, Cell, 43, 493, 10.1016/0092-8674(85)90179-5 · DOI
  23. Katz, 1997, Signal transduction from multiple Ras effectors, Curr. Opin. Genet. Dev., 7, 75, 10.1016/S0959-437X(97)80112-8 · DOI
  24. Kimble, 1981, Lineage alterations after ablation of cells in the somatic gonad of Caenorhabditis elegans, Dev. Biol., 87, 286, 10.1016/0012-1606(81)90152-4 · DOI
  25. Kobe, 1993, Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats, Nature, 366, 751, 10.1038/366751a0 · DOI
  26. Kobe, 1994, The leucine-rich repeat, Trends Biochem. Sci., 19, 415, 10.1016/0968-0004(94)90090-6 · DOI
  27. Kornfeld, 1997, Vulval development in Caenorhabditis elegans, Trends Genet., 13, 55, 10.1016/S0168-9525(97)01005-6 · DOI
  28. Kornfeld, 1995, The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in Caenorhabditis elegans, Cell, 83, 903, 10.1016/0092-8674(95)90206-6 · DOI
  29. Leon, 1987, Differential expression of the ras gene family in mice, Mol. Cell. Biol, 7, 1535, 10.1128/MCB.7.4.1535 · DOI
  30. Maduro, 1995, Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system, Genetics, 141, 977, 10.1093/genetics/141.3.977 · DOI
  31. Mello, 1991, Efficient gene transfer in C. elegans after microinjection of DNA into germline cytoplasm, EMBO J., 10, 3959, 10.1002/j.1460-2075.1991.tb04966.x · DOI
  32. Moodie, 1993, Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase, Science, 260, 1658, 10.1126/science.8503013 · DOI
  33. Rodriguez-Viciana, 1997, Role of phoshoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by ras, Cell, 89, 457, 10.1016/S0092-8674(00)80226-3 · DOI
  34. Rogalski, 1988, A Caenorhabditis elegans RNA polymerase II gene, ama-1 IV, and nearby essential genes, Genetics, 118, 61, 10.1093/genetics/118.1.61 · DOI
  35. Sundaram, 1995, The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction, Cell, 83, 889, 10.1016/0092-8674(95)90205-8 · DOI
  36. Sundaram, 1996, Control and integration of cell signaling pathways during C. elegans vulval development, BioEssays, 18, 473, 10.1002/bies.950180609 · DOI
  37. Sundaram, 1996, A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans, Development, 122, 2823, 10.1242/dev.122.9.2823 · DOI
  38. Suzuki, 1990, Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with RAS proteins, Proc. Natl. Acad. Sci. USA, 87, 8711, 10.1073/pnas.87.22.8711 · DOI
  39. Therrien, 1995, KSR, a novel protein kinase required for Ras signal transduction, Cell, 83, 879, 10.1016/0092-8674(95)90204-X · DOI
  40. Umanoff, 1995, The murine N-ras gene is not essential for growth and development, Prot. Natl. Acad. Sci. USA, 92, 1709, 10.1073/pnas.92.5.1709 · DOI
  41. Wassarman, 1995, The Ras signaling pathway in Drosophila, Curr. Opin. Genet. Dev., 5, 44, 10.1016/S0959-437X(95)90052-7 · DOI
  42. White, 1995, Multiple Ras functions can contribute to mammalian cell transformation, Cell, 80, 533, 10.1016/0092-8674(95)90507-3 · DOI
  43. Wu, 1994, Suppression of activated Let-60 Ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation, Genes Dev., 8, 147, 10.1101/gad.8.2.147 · DOI
  44. Yochem, 1997, Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans, Mol. Cell. Biol., 17, 2716, 10.1128/MCB.17.5.2716 · DOI
  45. Zhang, 1995, Ras-Raf complexes in vitro, Meth. Enzymol., 255, 323, 10.1016/S0076-6879(95)55035-6 · DOI

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Metadata

Authors
Sieburth, D. S., Sun, Q., & Han, M.
Venue
Cell
Publisher
Elsevier BV
Published
1998-07
Volume
94
Issue
1
Pages
119-130
ISSN
0092-8674
DOI
10.1016/s0092-8674(00)81227-1
Cited by
182
References
0
Language
en
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