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SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans

Sieburth, Derek S, Sun, Qun, Han, Min·1998·Cell
DOI 10.1016/s0092-8674(00)81227-1
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Abstract

We describe the identification and characterization of a novel gene, sur-8, that positively regulates Ras-mediated signal transduction during C. elegans vulval development. Reduction of sur-8 function suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations, while increase of sur-8 dosage enhances an activated ras mutation. sur-8 appears to act downstream of or in parallel to ras but upstream of raf. sur-8 encodes a conserved protein that is composed predominantly of leucine-rich repeats. The SUR-8 protein interacts directly with Ras but not with the Ras(P34G) mutant protein, suggesting that SUR-8 may mediate its effects through Ras binding. A structural and functional SUR-8 homolog in humans specifically binds K-Ras and N-Ras but not H-Ras in vitro.

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Metadata

Authors
Sieburth, D. S., Sun, Q., & Han, M.
Venue
Cell
Publisher
Elsevier BV
Published
1998-07
Volume
94
Issue
1
Pages
119-130
ISSN
0092-8674
DOI
10.1016/s0092-8674(00)81227-1
Cited by
182
References
0
Language
en
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