A Phosphatase Holoenzyme Comprised of Shoc2/Sur8 and the Catalytic Subunit of PP1 Functions as an M-Ras Effector to Modulate Raf Activity

Rodriguez-Viciana, Pablo; Oses-Prieto, Juan; Burlingame, Alma; Fried, Mike; McCormick, Frank

doi:10.1016/j.molcel.2006.03.027

Cited by 215Protein Kinase Regulation and GTPase SignalingProtein Tyrosine PhosphatasesMelanoma and MAPK Pathways

A Phosphatase Holoenzyme Comprised of Shoc2/Sur8 and the Catalytic Subunit of PP1 Functions as an M-Ras Effector to Modulate Raf Activity

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Rodriguez-Viciana, Pablo, Oses-Prieto, Juan, Burlingame, Alma, Fried, Mike, McCormick, Frank·2006·Molecular Cell

DOI 10.1016/j.molcel.2006.03.027

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Abstract

Ras family GTPases (RFGs) are known to share many regulatory and effector proteins. How signaling and biological specificity is achieved is poorly understood. Using a proteomics approach, we have identified a complex comprised of Shoc2/Sur-8 and the catalytic subunit of protein phosphatase 1 (PP1c) as a highly specific M-Ras effector. M-Ras targets Shoc2-PP1c to stimulate Raf activity by dephosphorylating the S259 inhibitory site of Raf proteins bound to other molecules of M-Ras or Ras. Therefore, distinct RFGs, through independent effectors, can regulate different steps in the activation of Raf kinases. Shoc2 function is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of Shoc2 expression inhibits MAPK, but not PI3K activity. We propose that the Shoc2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer.

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MRAS uniquely associates with SHOC2 and PPI1C as well as certain RapGEFs.
“it also uniquely associates with SHOC2 and PPI1C40 as well as certain RapGEFs52,53.”
From Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance (2024) · cites this paper as [40]
SOS1 and RasGRP1 facilitate GTP-loading of MRAS, which together with SHOC2 and PP1C forms a phosphatase complex that contributes to increased activation of RAS-MAPK signaling through dephosphorylation of inhibitory sites on RAF kinases.
“SOS1 and RasGRP1 have been shown to facilitate the GTP-loading of MRAS37,38, which, together with SHOC2 and PP1C, forms a phosphatase complex that contributes to the increased activation of RAS-MAPK signaling through dephosphorylation of inhibitory sites on RAF kinases40.”
From Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance (2024) · cites this paper as [40]

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Structure of the MRAS–SHOC2–PP1C phosphatase complex
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Cooperative assembly and structure of the RAS-SHOC2-PP1c holophosphatase provides \nmechanistic insights into disease-relevant mutations
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Authors: Rodriguez-Viciana, P., Oses-Prieto, J., Burlingame, A., Fried, M., & McCormick, F.
Affiliations: University of California, San Francisco (US)
ORCID: Burlingame, Alma
McCormick, Frank
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2006-04
Volume: 22
Issue: 2
Pages: 217-230
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2006.03.027
OpenAlex: W2049992341
Cited by: 215
References: 39
Citations by year: 2026: 10 · 2025: 11 · 2024: 18 · 2023: 8 · 2022: 20 · 2021: 10 · 2020: 6 · 2019: 15 · 2018: 11 · 2017: 7 · 2016: 16 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 14
FWCI: 2.31
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2664 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institutes of Health (1s10rr012961-01)
National Center for Research Resources (RR015804, RR 001614, RR-012961, P41RR001614, S10RR015804)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords: Ras family GTPases, MAPK pathway activation, oncogenic Ras mutations, cancer therapy targets, Ras effectors
MeSH terms: Carcinoma, Cell Line, Colonic Neoplasms, Electrophoresis, Polyacrylamide Gel, Enzyme Activation, Epidermal Growth Factor, Fibroblast Growth Factors, HeLa Cells, Humans, Phosphoric Monoester Hydrolases, Phosphoprotein Phosphatases, Precipitin Tests, Repressor Proteins, Retroviridae, Mass Spectrometry, Blotting, Western, Protein Structure, Tertiary, ras Proteins, Proto-Oncogene Proteins c-raf, Holoenzymes, Catalytic Domain, Mitogen-Activated Protein Kinases, RNA Interference, RNA, Small Interfering, Proteomics, HCT116 Cells, Intracellular Signaling Peptides and Proteins, Green Fluorescent Proteins, Protein Phosphatase 1

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A Phosphatase Holoenzyme Comprised of Shoc2/Sur8 and the Catalytic Subunit of PP1 Functions as an M-Ras Effector to Modulate Raf Activity

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