The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of a Stat Gene That Functions in Drosophila Development
Open accessAbstract
A Drosophila Stat gene (D-Stat) with a zygotic segmental expression pattern was identified. This protein becomes phosphorylated on Tyr-704 when coexpressed in Schneider cells with a Drosophila janus kinase (JAK), Hopscotch (HOP). The phosphorylated protein binds specifically to the consensus sequence TTCCCGGAA. Suppressor mutations of hopTum-I, a dominant hyperactive allele of hop whose phenotype is hematocyte overproduction and tumor formation, were selected. One of these mutants, statHJ, mapped to the same chromosomal region (92E) as does D-Stat, had an incompletely penetrant pair rule phenotype, and exhibited aberrant expression of the pair rule gene even skipped (eve) at the cellular blastoderm stage. Two D-STAT-binding sites were identified within the eve stripe 3 enhancer region. Mutations in either of the STAT-binding sites greatly decreased the stripe 3 expression in transgenic flies. Clearly, the JAK-STAT pathway is connected to Drosophila early development.
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Cites
Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070
Shuai, K., Horvath, C. M., Huang, L. H. T., Qureshi, S. A., Cowburn, D., & Darnell, J. E. (1994) · Cell · doi:10.1016/0092-8674(94)90357-3 · Cited by 807
Goto, T., Macdonald, P., & Maniatis, T. (1989) · Cell · doi:10.1016/0092-8674(89)90916-1 · Cited by 277
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Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
Self-citationSTATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
Bowman, T., Garcia, R., Turkson, J., & Jove, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203527 · Cited by 1,743
STATs: Signal Transducers and Activators of Transcription
Ihle, J. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81277-5 · Cited by 1,381
Metadata
- Authors
- Yan, R., Small, S., Desplan, C., Dearolf, C. R., & Darnell, J. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-02
- Volume
- 84
- Issue
- 3
- Pages
- 421-430
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2069605909
- Cited by
- 399
- References
- 3
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yan, R., Small, S., Desplan, C., Dearolf, C. R., & Darnell, J. E. (1996). Identification of a Stat Gene That Functions in Drosophila Development. Cell. https://doi.org/10.1016/s0092-8674(00)81287-8
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