The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues
Open accessAbstract
UNC-6 netrin, a laminin-related protein secreted from neuroglia and neurons along the ventral midline, orients migrating cells and pioneering growth cones on the nematode epidermis. UNC-5, a cell surface protein expressed on motile cells and pioneer axons, orients movements away from UNC-6 sources. UNC-40, a homolog of the cell surface proteins DCC (Deleted in Colorectal Cancer) and neogenin, is also expressed on motile cells and pioneer neurons. UNC-40 acts cell autonomously to orient movement toward UNC-6 sources. For cells coexpressing UNC-5, it helps orient movement away from UNC-6 sources. Finally, UNC-40 helps determine the dorsoventral position of cells undergoing purely longitudinal migrations. Together with the recent report that DCC is a netrin receptor in vertebrates, our results suggest that UNC-40 is a component of UNC-6 receptors on motile cells.
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Citations
Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
Cited by
Stein, E., & Tessier-Lavigne, M. (2001) · Science · doi:10.1126/science.1058445 · Cited by 601
RetractedExtracellular Matrix: Functions in the Nervous System
Barros, C. S., Franco, S. J., & Muller, U. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005108 · Cited by 506
The DCC Protein and Prognosis in Colorectal Cancer
Shibata, D., Reale, M. A., Lavin, P., Silverman, M., Fearon, E. R., Steele, G., Jessup, J. M., Loda, M., & Summerhayes, I. C. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612053352303 · Cited by 308
Signalling mechanisms mediating neuronal responses to guidance cues
Guan, K.-L., & Rao, Y. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1254 · Cited by 289
Cebrià, F., & Newmark, P. A. (2005) · Development · doi:10.1242/dev.01941 · Cited by 286
Metadata
- Authors
- Chan, S. S.-Y., Zheng, H., Su, M.-W., Wilk, R., Killeen, M. T., Hedgecock, E. M., & Culotti, J. G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-10
- Volume
- 87
- Issue
- 2
- Pages
- 187-195
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2090865074
- Cited by
- 504
- References
- 1
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81337-9
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- Chan, S. S.-Y., Zheng, H., Su, M.-W., Wilk, R., Killeen, M. T., Hedgecock, E. M., & Culotti, J. G. (1996). UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues. Cell. https://doi.org/10.1016/s0092-8674(00)81337-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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