The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The DCC Protein and Prognosis in Colorectal Cancer
Open accessAbstract
BACKGROUND: Allelic loss of chromosome 18q predicts a poor outcome in patients with stage II colorectal cancer. Although the specific gene inactivated by this allelic loss has not been elucidated, the DCC (deleted in colorectal cancer) gene is a candidate. We investigated whether the expression of the DCC protein in tumor cells is a prognostic marker in colorectal carcinoma. METHODS: The expression of DCC was evaluated immunohistochemically in 132 paraffin-embedded samples from patients with curatively resected stage II and III colorectal carcinomas. The Cox proportional-hazards model was used to adjust for covariates including age, sex, tumor site, degree of tumor differentiation, and use of adjuvant therapy. RESULTS: The expression of DCC was a strong positive predictive factor for survival in both stage II and stage III colorectal carcinomas. In patients with stage II disease whose tumors expressed DCC, the five-year survival rate was 94.3 percent, whereas in patients with DCC-negative tumors, the survival rate was 61.6 percent (P<0.001). In patients with stage III disease, the respective survival rates were 59.3 percent and 33.2 percent (P=0.03). CONCLUSIONS: DCC is a prognostic marker in patients with stage II or stage III colorectal cancer. In stage II colorectal carcinomas, the absence of DCC identifies a subgroup of patients with lesions that behave like stage III cancers. These findings may thus have therapeutic implications in this group of patients.
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Cites
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DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
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Self-citationAllelotype of Colorectal Carcinomas
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Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor
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Cited by
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Dependence receptors: a new paradigm in cell signaling and cancer therapy
Goldschneider, D., & Mehlen, P. (2010) · Oncogene · doi:10.1038/onc.2010.13 · Cited by 169
Dependence receptors and colorectal cancer
Mehlen, P., & Tauszig-Delamasure, S. (2014) · Gut · doi:10.1136/gutjnl-2013-306704 · Cited by 44
Metadata
- Authors
- Shibata, D., Reale, M. A., Lavin, P., Silverman, M., Fearon, E. R., Steele, G., Jessup, J. M., Loda, M., & Summerhayes, I. C.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1996-12-05
- Volume
- 335
- Issue
- 23
- Pages
- 1727-1732
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2327245331
- Cited by
- 308
- References
- 31
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shibata, D., Reale, M. A., Lavin, P., Silverman, M., Fearon, E. R., Steele, G., Jessup, J. M., Loda, M., & Summerhayes, I. C. (1996). The DCC Protein and Prognosis in Colorectal Cancer. New England Journal of Medicine. https://doi.org/10.1056/nejm199612053352303
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