The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells
Open accessAbstract
Dendritic cells (DCs) developmentally regulate their capacity for antigen presentation by controlling the transport and surface expression of MHC class II molecules. These events reflect a developmental regulation of invariant (Ii) chain cleavage, most likely by the cysteine protease cathepsin S. In immature DCs, inefficient Ii chain cleavage due to low cathepsin S activity leads to the transport of class II-Ii chain complexes to lysosomes, while in mature DCs, elevated cathepsin S activity results in efficient delivery of class II alphabeta dimers to the plasma membrane. Cathepsin S is not controlled transcriptionally but by a novel mechanism involving alterations in the expression and localization of an endogenous cathepsin S inhibitor cystatin C. Thus, the ratio of cystatin C to cathepsin S in developing DCs helps to determine the fate of newly synthesized MHC class II molecules.
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Warfel, A. H., Zucker-Franklin, D., Frangione, B., & Ghiso, J. (1987) · The Journal of experimental medicine · doi:10.1084/jem.166.6.1912 · Cited by 126
Cited by
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Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,926
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H.-W., Park, C. G., et al. (2007) · Science · doi:10.1126/science.1136080 · Cited by 1,455
Phagocytosis and antigen presentation in dendritic cells
Savina, A., & Amigorena, S. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00552.x · Cited by 561
Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
Turley, S. J., Inaba, K., Garrett, W. S., Ebersold, M., Unternaehrer, J., Steinman, R. M., & Mellman, I. (2000) · Science · doi:10.1126/science.288.5465.522 · Cited by 477
Self-citationThe cell biology of antigen presentation in dendritic cells
Théry, C., & Amigorena, S. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00180-1 · Cited by 428
Metadata
- Authors
- Pierre, P., & Mellman, I.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 93
- Issue
- 7
- Pages
- 1135-1145
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1980008292
- Cited by
- 391
- References
- 1
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pierre, P., & Mellman, I. (1998). Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells. Cell. https://doi.org/10.1016/s0092-8674(00)81458-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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