The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria
Open accessAbstract
Mouse kif5B gene was disrupted by homologous recombination. kif5B-/- mice were embryonic lethal with a severe growth retardation at 9.5-11.5 days postcoitum. To analyze the significance of this conventional kinesin heavy chain in organelle transport, we studied the distribution of major organelles in the extraembryonic cells. The null mutant cells impaired lysosomal dispersion, while brefeldin A could normally induce the breakdown of their Golgi apparatus. More prominently, their mitochondria abnormally clustered in the perinuclear region. This mitochondrial phenotype was reversed by an exogenous expression of KIF5B, and a subcellular fractionation revealed that KIF5B is associated with mitochondria. These data collectively indicate that kinesin is essential for mitochondrial and lysosomal dispersion rather than for the Golgi-to-ER traffic in these cells.
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In the citing paper
“Gene targeting of the ubiquitous KIF5B in mice, however, resulted in embryonic lethality (Tanaka et al. 1998).”
From Defective kinesin heavy chain behavior in mouse kinesin light chain mutants (1999) · cites this paper as Tanaka et al. 1998
In the citing paper
“Kinesin-1C mRNA expression was upregulated in Kinesin-1B null extraembryonic membranes”
From Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles (2011) · cites this paper as Tanaka et al., 1998
Citations
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Sorted by citations
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
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Self-citationDynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells
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Self-citationThe axonal transport of mitochondria
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Metadata
- Authors
- Tanaka, Y., Kanai, Y., Okada, Y., Nonaka, S., Takeda, S., Harada, A., & Hirokawa, N.
- Affiliations
- The University of Tokyo (JP)
- Corresponding author
- Hirokawa, Nobutaka
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 93
- Issue
- 7
- Pages
- 1147-1158
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2095841601
- Semantic Scholar
- 936e428e5d9d833db465aefd6f33c879e6ea0468
- Cited by
- 654
- References
- 81
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 24 · 2023: 13 · 2022: 24 · 2021: 27 · 2020: 25 · 2019: 23 · 2018: 24 · 2017: 27 · 2016: 34 · 2015: 24 · 2014: 22 · 2013: 27 · 2012: 31
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- KIF5B, mitochondrial clustering, organelle transport, Golgi apparatus, brefeldin A, extraembryonic cells, embryonic lethality
- MeSH terms
- Animals, Anti-Bacterial Agents, Cell Fractionation, Cell Nucleus, Cells, Cultured, Cyclopentanes, Genes, Lethal, Golgi Apparatus, Lysosomes, Microtubules, Mitochondria, Phenotype, RNA, Messenger, Yolk Sac, Nocodazole, Kinesins, Mice, Knockout, Gene Expression Regulation, Developmental, Macrolides, Brefeldin A, Mice
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