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A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth
Open accessAbstract
Caveolin-1 functions as a membrane adaptor to link the integrin alpha subunit to the tyrosine kinase Fyn. Upon integrin ligation, Fyn is activated and binds, via its SH3 domain, to Shc. Shc is subsequently phosphorylated at tyrosine 317 and recruits Grb2. This sequence of events is necessary to couple integrins to the Ras-ERK pathway and promote cell cycle progression. These findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth.
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Citations
Cited by
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Parton, R. G., & Simons, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2122 · Cited by 1,454
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Paoli, P., Giannoni, E., & Chiarugi, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.026 · Cited by 1,160
Metadata
- Authors
- Wary, K. K., Mariotti, A., Zurzolo, C., & Giancotti, F. G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 94
- Issue
- 5
- Pages
- 625-634
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2083358105
- Cited by
- 718
- References
- 0
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81604-9
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- Wary, K. K., Mariotti, A., Zurzolo, C., & Giancotti, F. G. (1998). A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth. Cell. https://doi.org/10.1016/s0092-8674(00)81604-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
