The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Building a Replisome from Interacting Pieces
Open accessAbstract
We have solved the crystal structures of the bacteriophage RB69 sliding clamp, its complex with a peptide essential for DNA polymerase interactions, and the DNA polymerase complexed with primer-template DNA. The editing complex structure shows a partially melted duplex DNA exiting from the exonuclease domain at an unexpected angle and significant changes in the protein structure. The clamp complex shows the C-terminal 11 residues of polymerase bound in a hydrophobic pocket, and it allows docking of the editing and clamp structures together. The peptide binds to the sliding clamp at a position identical to that of a replication inhibitor peptide bound to PCNA, suggesting that the replication inhibitor protein p21CIP1 functions by competing with eukaryotic polymerases for the same binding pocket on the clamp.
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Cites
[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
Brautigam, C. A., & Steitz, T. A. (1998) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(98)80010-9 · Cited by 377
Self-citationModular Organization of T4 DNA Polymerase
Wang, C.-C., Yeh, L.-S., & Karam, J. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26558 · Cited by 94
Cited by
Synthetic genetic polymers capable of heredity and evolution
Pinheiro, V. B., Taylor, A. I., Cozens, C., Abramov, M., Renders, M., Zhang, S., Chaput, J. C., Wengel, J., Peak-Chew, S.-Y., McLaughlin, S. H., et al. (2012) · Science · doi:10.1126/science.1217622 · Cited by 730
Hübscher, U., Maga, G., & Spadari, S. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150041 · Cited by 691
Structure of the Replicating Complex of a Pol α Family DNA Polymerase
Franklin, M. C., Wang, J., & Steitz, T. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00367-1 · Cited by 538
Self-citationStructural analysis of a eukaryotic sliding DNA clamp–clamp loader complex
Bowman, G. D., O'Donnell, M., & Kuriyan, J. (2004) · Nature · doi:10.1038/nature02585 · Cited by 451
The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase
Yin, Y. W., & Steitz, T. A. (2004) · Cell · doi:10.1016/s0092-8674(04)00120-5 · Cited by 337
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Metadata
- Authors
- Shamoo, Y., & Steitz, T. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 99
- Issue
- 2
- Pages
- 155-166
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W47123523
- Cited by
- 363
- References
- 4
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
