The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs
Open accessAbstract
PPARB was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC) cells. PPARdelta expression was elevated in CRCs and repressed by APC in CRC cells. This repression was mediated by beta-catenin/Tcf-4-responsive elements in the PPARdelta promotor. The ability of PPARs to bind eicosanoids suggested that PPARdelta might be a target of chemopreventive non-steroidal anti-inflammatory drugs (NSAIDs). Reporters containing PPARdelta-responsive elements were repressed by the NSAID sulindac. Furthermore, sulindac was able to disrupt the ability of PPARdelta to bind its recognition sequences. These findings suggest that NSAIDs inhibit tumorigenesis through inhibition of PPARdelta, the gene for which is normally regulated by APC.
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Cited by
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Metadata
- Authors
- He, T.-C., Chan, T. A., Vogelstein, B., & Kinzler, K. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 99
- Issue
- 3
- Pages
- 335-345
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1979201752
- Cited by
- 1,085
- References
- 55
- FWCI
- 30.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- He, T.-C., Chan, T. A., Vogelstein, B., & Kinzler, K. W. (1999). PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs. Cell. https://doi.org/10.1016/s0092-8674(00)81664-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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