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The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

Korinek, Vladimir, Barker, Nick, Morin, Patrice J., van Wichen, Dick, de Weger, Roel, Kinzler, Kenneth W., Vogelstein, Bert, Clevers, Hans·1997·Science
DOI 10.1126/science.275.5307.1784
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Abstract

The adenomatous polyposis coli (APC) tumor suppressor protein binds to β-catenin, a protein recently shown to interact with Tcf and Lef transcription factors. The gene encoding hTcf-4, a Tcf family member that is expressed in colonic epithelium, was cloned and characterized. hTcf-4 transactivates transcription only when associated with β-catenin. Nuclei of APC −/− colon carcinoma cells were found to contain a stable β-catenin-hTcf-4 complex that was constitutively active, as measured by transcription of a Tcf reporter gene. Reintroduction of APC removed β-catenin from hTcf-4 and abrogated the transcriptional transactivation. Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.

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  • The TOP-FLASH luciferase reporter contains TCF-binding sites and can be directly activated by the β-catenin/TCF complex.

    “The TOP-FLASH luciferase reporter contains TCF-binding sites and can be directly activated by the ␤-catenin/TCF complex (Korinek et al., 1997).”

    From Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding (2005) · cites this paper as Korinek et al., 1997

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Research works printed but not linked: 17

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Metadata

Authors
Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., & Clevers, H.
Affiliations
  • V. Korinek, N. Barker, H. Clevers, Department of Immunology, University Hospital, Post Office Box B85500, 3508 GA Utrecht, Netherlands.
  • P. J. Morin and B. Vogelstein, Howard Hughes Medical Institute, Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA.
  • D. van Wichen and R. de Weger, Department of Pathology, University Hospital, 3508 GA Utrecht, Netherlands.
  • K. W. Kinzler, Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1997-03-21
Volume
275
Issue
5307
Pages
1784-1787
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.275.5307.1784
Cited by
2,905
References
1
Language
en

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