Mammalian sweet taste receptors
Open accessAbstract
The sense of taste provides animals with valuable information about the quality and nutritional value of food. Previously, we identified a large family of mammalian taste receptors involved in bitter taste perception (the T2Rs). We now report the characterization of mammalian sweet taste receptors. First, transgenic rescue experiments prove that the Sac locus encodes T1R3, a member of the T1R family of candidate taste receptors. Second, using a heterologous expression system, we demonstrate that T1R2 and T1R3 combine to function as a sweet receptor, recognizing sweet-tasting molecules as diverse as sucrose, saccharin, dulcin, and acesulfame-K. Finally, we present a detailed analysis of the patterns of expression of T1Rs and T2Rs, thus providing a view of the representation of sweet and bitter taste at the periphery.
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All known sweet tastants are sensed by a single broadly tuned sweet taste receptor heterodimer of T1R2 and T1R3.
“All known sweet tastants, including hexose sugars, D-amino acids, sweet proteins (such as monellin and thaumatin), and low-calorie sweeteners (LCS) are sensed by a single broadlytuned sweet taste receptor (STR), comprised of a heterodimer of class C, G-protein coupled receptors, T1R2, and T1R3 (15).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [15]
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“Frontiers in Endocrinology | www.frontiersin.org 2 December 2018 | Volume 9 | Article 741 The latter is evidenced in mice lacking T1R3 or α-gustducin, where SGLT-1 expression and function are not increased in response to dietary glucose or LCS supplementation as occurs in control mice (42).”
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- Authors
- Nelson, G., Hoon, M. A., Chandrashekar, J., Zhang, Y., Ryba, N. J. P., & Zuker, C. S.
- Affiliations
- Howard Hughes Medical Institute (US)
- National Institutes of Health (US)
- Corresponding author
- Ryba, Nicholas J.P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 106
- Issue
- 3
- Pages
- 381-390
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4249590403
- Cited by
- 1,702
- References
- 40
- Citations by year
- 2026: 55 · 2025: 69 · 2024: 61 · 2023: 60 · 2022: 71 · 2021: 92 · 2020: 73 · 2019: 82 · 2018: 66 · 2017: 66 · 2016: 75 · 2015: 65 · 2014: 60 · 2013: 68 · 2012: 80
- FWCI
- 53.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, San Diego
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- sweet taste receptor, T1R2, T1R3, sucrose, saccharin, dulcin, acesulfame-K, transgenic rescue, receptor expression patterns, taste perception
- MeSH terms
- Animals, Cell Line, Chromosomes, Human, Pair 4, Multigene Family, Genetic Complementation Test, Cricetinae, Humans, Mice, Transgenic, Molecular Sequence Data, Phenylurea Compounds, Receptors, Cell Surface, RNA, Messenger, Saccharin, Substrate Specificity, Sucrose, Sweetening Agents, Taste, Taste Buds, Thiazines, Evolution, Molecular, Calcium Signaling, Physical Chromosome Mapping, Gene Expression Profiling, Heterotrimeric GTP-Binding Proteins, Receptors, G-Protein-Coupled, Mice
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