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Regulation of Motor Neuron Pool Sorting by Differential Expression of Type II Cadherins
Open accessAbstract
During spinal cord development, motor neurons with common targets and afferent inputs cluster into discrete nuclei, termed motor pools. Motor pools can be delineated by transcription factor expression, but cell surface proteins that distinguish motor pools in a systematic manner have not been identified. We show that the developmentally regulated expression of type II cadherins defines specific motor pools. Expression of one type II cadherin, MN-cadherin, regulates the segregation of motor pools that are normally distinguished by expression of this protein. Type II cadherins are also expressed by proprioceptive sensory neurons, raising the possibility that cadherins regulate additional steps in the development of sensory-motor circuits.
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“In the spinal cord, differential cell adhesion is essential for the clustering of MNs into distinct pools”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Price et al., 2002
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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
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Metadata
- Authors
- Price, S. R., De Marco Garcia, N. V., Ranscht, B., & Jessell, T. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Jessell, Thomas M
- ORCID
- Price, Stephen R
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 109
- Issue
- 2
- Pages
- 205-216
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2157609395
- Cited by
- 304
- References
- 50
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 13 · 2014: 19 · 2013: 11 · 2012: 16
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 25938, P01HD025938)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- motoneuron pools, spinal cord development, proprioceptive sensory neurons, sensory-motor circuits, cell surface proteins, transcription factors
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Chick Embryo, DNA-Binding Proteins, Ganglia, Spinal, Molecular Sequence Data, Motor Neurons, Mutation, Neurons, Afferent, Proprioception, Spinal Cord, Transcription Factors, Cadherins, Glycosyltransferases, DNA, Complementary, Electroporation, Gene Expression Regulation, Developmental, Body Patterning, Protein Isoforms
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