The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones
Open accessAbstract
Molecular mechanisms linking pre- and postsynaptic membranes at the interneuronal synapses are little known. We tested the cadherin adhesion system for its localization in synapses of mouse and chick brains. We found that two classes of cadherin-associated proteins, alpha N- and beta-catenin, are broadly distributed in adult brains, colocalizing with a synaptic marker, synaptophysin. At the ultrastructural level, these proteins were localized in synaptic junctions of various types, forming a symmetrical adhesion structure. These structures sharply bordered the transmitter release sites associated with synaptic vesicles, although their segregation was less clear in certain types of synapses. N-cadherin was also localized at a similar site of synaptic junctions but in restricted brain nuclei. In developing synapses, the catenin-bearing contacts dominated their junctional structures. These findings demonstrate that interneuronal synaptic junctions comprise two subdomains, transmitter release zone and catenin-based adherens junction. The catenins localized in these junctions are likely associated with certain cadherin molecules including N-cadherin, and the cadherin/ catenin complex may play a critical role in the formation or maintenance of synaptic junctions.
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The perisynaptic zone contains transsynaptic cell-adhesion molecules such as cadherins.
“The perisynaptic zone is the site of synaptic vesicle endocytosis (Brodin and Shupliakov, 2006), contains transsynaptic cell-adhesion molecules such as cadherins (Uchida et al., 1996) and harbors presynaptic receptors such as endocannabinoid CB1 receptors that control neurotransmitter release (Nyíri et al., 2005).”
From The Presynaptic Active Zone (2012) · cites this paper as Uchida et al., 1996
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- Authors
- Uchida, N., Honjo, Y., Johnson, K. R., Wheelock, M. J., & Takeichi, M.
- Affiliations
- Kyoto University (JP)
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-11-01
- Volume
- 135
- Issue
- 3
- Pages
- 767-779
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2121068
- OpenAlex
- W2039378730
- Cited by
- 501
- References
- 1
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 8 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 13 · 2017: 10 · 2016: 6 · 2015: 22 · 2014: 13 · 2013: 11 · 2012: 16
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- N-cadherin, β-catenin, synapses, synaptophysin, adherens junctions, synaptic vesicles, synaptic development, mouse brain, chick brain
- MeSH terms
- Animals, Brain Chemistry, Cell Nucleus, Cells, Cultured, Chickens, Cytoskeletal Proteins, Mice, Inbred ICR, Neurons, Purkinje Cells, RNA, Messenger, Synapses, Synaptic Vesicles, Trans-Activators, Cadherins, Synaptophysin, beta Catenin, alpha Catenin, Mice
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