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Cited by 304Axon Guidance and Neuronal SignalingDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Regulation of Motor Neuron Pool Sorting by Differential Expression of Type II Cadherins

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Price, Stephen R, De Marco Garcia, Natalia V, Ranscht, Barbara, Jessell, Thomas M·2002·Cell
DOI 10.1016/s0092-8674(02)00695-5
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Abstract

During spinal cord development, motor neurons with common targets and afferent inputs cluster into discrete nuclei, termed motor pools. Motor pools can be delineated by transcription factor expression, but cell surface proteins that distinguish motor pools in a systematic manner have not been identified. We show that the developmentally regulated expression of type II cadherins defines specific motor pools. Expression of one type II cadherin, MN-cadherin, regulates the segregation of motor pools that are normally distinguished by expression of this protein. Type II cadherins are also expressed by proprioceptive sensory neurons, raising the possibility that cadherins regulate additional steps in the development of sensory-motor circuits.

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Crossref · 10.1016/s0092-8674(02)00695-5

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Metadata

Authors
Price, S. R., De Marco Garcia, N. V., Ranscht, B., & Jessell, T. M.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author
Jessell, Thomas M
ORCID
Price, Stephen R
Venue
Cell
Publisher
Elsevier BV
Published
2002-04
Volume
109
Issue
2
Pages
205-216
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/s0092-8674(02)00695-5
OpenAlex
W2157609395
Cited by
304
References
50
Citations by year
2026: 5 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 13 · 2014: 19 · 2013: 11 · 2012: 16
FWCI
8.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 25938, P01HD025938)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
motoneuron pools, spinal cord development, proprioceptive sensory neurons, sensory-motor circuits, cell surface proteins, transcription factors
MeSH terms
Animals, Cell Differentiation, Cell Movement, Chick Embryo, DNA-Binding Proteins, Ganglia, Spinal, Molecular Sequence Data, Motor Neurons, Mutation, Neurons, Afferent, Proprioception, Spinal Cord, Transcription Factors, Cadherins, Glycosyltransferases, DNA, Complementary, Electroporation, Gene Expression Regulation, Developmental, Body Patterning, Protein Isoforms

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