The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
IL-4 Acts as a Myoblast Recruitment Factor during Mammalian Muscle Growth
Open accessAbstract
Skeletal muscle formation and growth require the fusion of myoblasts to form multinucleated myofibers or myotubes, but few molecules are known to regulate myoblast fusion in mammals. The transcription factor NFATc2 controls myoblast fusion at a specific stage of myogenesis after the initial formation of a myotube and is necessary for further cell growth. By examining genes regulated by NFATc2 in muscle, this study identifies the cytokine IL-4 as a molecular signal that controls myoblast fusion with myotubes. Muscle cells lacking IL-4 or the IL-4alpha receptor subunit form normally but are reduced in size and myonuclear number. IL-4 is expressed by a subset of muscle cells in fusing muscle cultures and requires the IL-4alpha receptor subunit on myoblasts to promote fusion and growth. These data demonstrate that following myotube formation, myotubes recruit myoblast fusion by secretion of IL-4, leading to muscle growth.
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Cites
Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583
The IL-4 receptor: signaling mechanisms and biologic functions
Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.701 · Cited by 1,545 · cited 3×
“The receptor for IL-4 consists of the IL-4R subunit and the c subunit in immune cells or IL-13R 1 in nonlymphoid tissues (Nelms et al., 1999).”
BackgroundInfluentialInterleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression
DeFife, K. M., Jenney, C. R., McNally, A. K., Colton, E., & Anderson, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3385 · Cited by 228
McNally, A. K., & Anderson, J. M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64882-1 · Cited by 225
Cited by
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002
Mechanisms regulating skeletal muscle growth and atrophy
Schiaffino, S., Dyar, K. A., Ciciliot, S., Blaauw, B., & Sandri, M. (2013) · The FEBS Journal · doi:10.1111/febs.12253 · Cited by 1,492
Regulatory interactions between muscle and the immune system during muscle regeneration
Tidball, J. G., & Villalta, S. A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00735.2009 · Cited by 1,105
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.011 · Cited by 873
Metadata
- Authors
- Horsley, V., Jansen, K. M., Mills, S. T., & Pavlath, G. K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 113
- Issue
- 4
- Pages
- 483-494
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1980811848
- Cited by
- 508
- References
- 4
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Horsley, V., Jansen, K. M., Mills, S. T., & Pavlath, G. K. (2003). IL-4 Acts as a Myoblast Recruitment Factor during Mammalian Muscle Growth. Cell. https://doi.org/10.1016/s0092-8674(03)00319-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
