Are ubiquitination pathways central to Parkinson’s disease?

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

Diagnostic Criteria for Parkinson Disease

Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Shimura, H., Hattori, N., Kubo, S.-I., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., et al. (2000) · Nature Genetics · doi:10.1038/77060 · Cited by 2,024

Recognition of the polyubiquitin proteolytic signal

Thrower, J. S., Hoffman, L. M., Rechsteiner, M., & Pickart, C. M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.1.94 · Cited by 1,769

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

Hochstrasser, M. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.405 · Cited by 1,706

The ubiquitin pathway in Parkinson's disease

Leroy, E., Boyer, R., Auburger, G. W. J., Leube, B., Ulm, G., Mezey, É., Harta, G., Brownstein, M., Jonnalagada, S., Chernova, T., et al. (1998) · Nature · doi:10.1038/26652 · Cited by 1,599

Neuropathology of Parkinson's Disease

Forno, L. (1996) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199603000-00001 · Cited by 1,556

Alpha-synuclein and neurodegenerative diseases

Goedert, M. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081564 · Cited by 1,428

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737556100 · Cited by 1,203

Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease

Shimura, H., Schlossmacher, M. G., Hattori, N., Frosch, M. P., Trockenbacher, A., Schneider, R., Mizuno, Y., Kosik, K. S., & Selkoe, D. J. (2001) · Science · doi:10.1126/science.1060627 · Cited by 1,053

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin

Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuno, Y., & Takahashi, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00407-x · Cited by 1,050

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Zhang, Y., Gao, J., Chung, K. K. K., Huang, H., Dawson, V. L., & Dawson, T. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240347797 · Cited by 982

Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A., & Price, D. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132197599 · Cited by 824

Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease

Hughes, A. J., Daniel, S. E., & Lees, A. J. (2001) · Neurology · doi:10.1212/wnl.57.8.1497 · Cited by 807

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

Liu, Y., Fallon, L., Lashuel, H. A., Liu, Z., & Lansbury, P. T. (2002) · Cell · doi:10.1016/s0092-8674(02)01012-7 · Cited by 786

Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease

Xu, J., Kao, S., Lee, F. J. S., Song, W., Jin, L., & Yankner, B. A. (2002) · Nature Medicine · doi:10.1038/nm0602-600 · Cited by 768

Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity

Imai, Y., Soda, M., & Takahashi, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000447200 · Cited by 766

Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

Chung, K. K. K., Zhang, Y., Lim, K. L., Tanaka, Y., Huang, H., Gao, J., Ross, C. A., Dawson, V. L., & Dawson, T. M. (2001) · Nature Medicine · doi:10.1038/nm1001-1144 · Cited by 750

Proteasomal function is impaired in substantia nigra in Parkinson’s disease

McNaught, K. S. P., & Jenner, P. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01701-8 · Cited by 653

Parkin Protects against the Toxicity Associated with Mutant α-Synuclein

Petrucelli, L., O’Farrell, C., Lockhart, P. J., Baptista, M. J., Kehoe, K. J., Vink, L., Choi, P., Wolozin, B. L., Farrer, M. J., Hardy, J., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)01125-x · Cited by 561

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

Saigoh, K., Wang, Y., Suh, J., Yamanishi, T., Sakai, Y., Kiyosawa, H., Harada, T., Ichihara, N., Wakana, S., Kikuchi, T., et al. (1999) · Nature Genetics · doi:10.1038/12647 · Cited by 501

CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity

Imai, Y., Soda, M., Hatakeyama, S., Akagi, T., Hashikawa, T., Nakayama, K. I., & Takahashi, R. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00583-x · Cited by 477

Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson’s disease?

Goldberg, M. S., & Lansbury, P. T. (2000) · Nature Cell Biology · doi:10.1038/35017124 · Cited by 459

Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult

Paxinou, E., Chen, Q., Weisse, M., Giasson, B. I., Norris, E. H., Rueter, S. M., Trojanowski, J. Q., Lee, V. M. ‐., & Ischiropoulos, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08053.2001 · Cited by 440

Aggregated and Monomeric α-Synuclein Bind to the S6′ Proteasomal Protein and Inhibit Proteasomal Function

Snyder, H. M., Mensah, K., Theisler, C. M., Lee, J., Matouschek, A. T., & Wolozin, B. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208641200 · Cited by 430

Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions

Hasegawa, M., Fujiwara, H., Nonaka, T., Wakabayashi, K., Takahashi, H., Lee, V. M.-Y., Trojanowski, J. Q., Mann, D., & Iwatsubo, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208046200 · Cited by 428

Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity

Staropoli, J. F., McDermott, C., Martinat, C., Schulman, B. A., Demireva, E. Y., & Abeliovich, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00084-9 · Cited by 388

Parkin Suppresses Dopaminergic Neuron-Selective Neurotoxicity Induced by Pael-R in Drosophila

Yang, Y., Nishimura, I., Imai, Y., Takahashi, R., & Lu, B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00143-0 · Cited by 367

α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome

Tofaris, G. K., Layfield, R., & Spillantini, M. G. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03115-5 · Cited by 363

PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone

Benaroudj, N., & Goldberg, A. (2000) · Nature Cell Biology · doi:10.1038/35041081 · Cited by 330

Concurrence of α-synuclein and tau brain pathology in the Contursi kindred

Duda, J. E., Giasson, B. I., Mabon, M. E., Miller, D. C., Golbe, L. I., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0563-3 · Cited by 274

Immunocytochemical Co-localization of the Proteasome in Ubiquitinated Structures in Neurodegenerative Diseases and the Elderly

Ii, K., Ito, H., Tanaka, K., & Hirano, A. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199702000-00002 · Cited by 218

Complex relationship between Parkin mutations and Parkinson disease

West, A. B., Periquet, M., Lincoln, S., Lücking, C. B., Nicholl, D. J., Bonifati, V., Rawal, N., Gasser, T., Lohmann, E., Deleuze, J., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10525 · Cited by 205

Parkin and the Molecular Pathways of Parkinson's Disease

Giasson, B. I., & Lee, V. M. ‐. (2001) · Neuron · doi:10.1016/s0896-6273(01)00439-1 · Cited by 159

Animal Models of PD

Dawson, T. M., Mandir, A. S., & Lee, M. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00780-8 · Cited by 137

Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson's disease

Mattila, P. M., Röyttä, M., Torikka, H., Dickson, D. W., & Rinne, J. O. (1998) · Acta Neuropathologica · doi:10.1007/s004010050843 · Cited by 130

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

Satoh, J., & Kuroda, Y. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00555-x · Cited by 91

Immunocytochemical localization of synphilin-1, an α-synuclein-associated protein, in neurodegenerative disorders

Wakabayashi, K., Engelender, S., Tanaka, Y., Yoshimoto, M., Mori, F., Tsuji, S., Ross, C. A., & Takahashi, H. (2001) · Acta Neuropathologica · doi:10.1007/s004010100451 · Cited by 84

MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE

Moore, D. J., West, A. B., Dawson, V. L., & Dawson, T. M. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135718 · Cited by 1,304

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

Pandey, U. B., & Nichols, C. D. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003293 · Cited by 1,225

Discovering Endophenotypes for Major Depression

Hasler, G., Drevets, W. C., Manji, H. K., & Charney, D. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300506 · Cited by 1,123

The Ubiquitin Proteasome System in Neurodegenerative Diseases

Ciechanover, A. J., & Brundin, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00606-8 · Cited by 1,000

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

Forman, M. S., Trojanowski, J. Q., & Lee, V. M.-Y. (2004) · Nature Medicine · doi:10.1038/nm1113 · Cited by 715

Role of the ubiquitin proteasome system in Parkinson's disease

Lim, K., & Tan, J. M. (2007) · BMC Biochemistry · doi:10.1186/1471-2091-8-s1-s13 · Cited by 161

BMC Biochemistry BioMed Central Review Role of the ubiquitin proteasome system in Parkinson's disease

Lim, K.-L., Mm, J., & Access, T. O. (2007)

Mechanism of Parkinson's disease resulted from ubiquitin-proteasome system dysfunction

Li, Y. (2009) · International Journal of Pathology and Clinical Medicine

Ubiquitin–proteasome system and Parkinson's diseases

Betarbet, R. S., Sherer, T., & Greenamyre, J. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.08.021 · Cited by 248

Ubiquitin–proteasome system dysfunction in Parkinson’s disease: current evidence and controversies

Lim, K. (2007) · Expert Review of Proteomics · doi:10.1586/14789450.4.6.769 · Cited by 72