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Cited by 391

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells

Open access
Tardieux, Isabelle, Webster, Paul, Ravesloot, Jan, Boron, Walter, Lunn, J. Adrian, Heuser, John E., Andrews, Norma W.·1992·Cell
DOI 10.1016/s0092-8674(05)80061-3
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Abstract

Trypanosoma cruzi invades most nucleated cells by a mechanism distinct from classical phagocytosis. Although parasites enter at the lysosome-poor peripheral cell margins, lysosomal markers are immediately incorporated into the parasitophorous vacuole. No accumulation of polymerized actin was detected around recently internalized parasites, and disruption of microfilaments significantly facilitated invasion. Lysosomes were observed to aggregate at the sites of trypanosome attachment and to fuse with the vacuole at early stages of its formation. Experimentally induced, microtubule-dependent movement of lysosomes from the perinuclear area to the cell periphery enhanced entry. Conditions that deplete cells of peripheral lysosomes or interfere with lysosomal fusion capacity inhibited invasion. These observations reveal a novel mechanism for cell invasion:recruitment of lysosomes for fusion at the site of parasite internalization.

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Metadata

Authors
Tardieux, I., Webster, P., Ravesloot, J., Boron, W., Lunn, J. A., Heuser, J. E., & Andrews, N. W.
Venue
Cell
Publisher
Elsevier BV
Published
1992-12
Volume
71
Issue
7
Pages
1117-1130
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/s0092-8674(05)80061-3
OpenAlex
W2031183620
Cited by
391
References
54
FWCI
7.72
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells. https://app.cochat.ai/papers/10.1016/s0092-8674(05)80061-3
The paper
Tardieux, I., Webster, P., Ravesloot, J., Boron, W., Lunn, J. A., Heuser, J. E., & Andrews, N. W. (1992). Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells. Cell. https://doi.org/10.1016/s0092-8674(05)80061-3

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.