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Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

Saftig, Paul, Klumperman, Judith·2009·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm2745
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Abstract

Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade extracellular material that has been internalized by endocytosis and intracellular components that have been sequestered by autophagy. In addition, specialized cells contain lysosome-related organelles that store and secrete proteins for cell-type-specific functions. The functioning of a healthy cell is dependent on the proper targeting of newly synthesized lysosomal proteins. Accumulating evidence suggests that there are multiple lysosomal delivery pathways that together allow the regulated and sequential deposition of lysosomal components. The importance of lysosomal trafficking pathways is emphasized by recent findings that reveal new roles for lysosomal membrane proteins in cellular physiology and in an increasing number of diseases that are characterized by defects in lysosome biogenesis.

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  • LAMP2 (along with LAMP1) is a structural lysosomal membrane protein marker used to identify lysosomes and late endo/lysosomal compartments.

    “LAMP2 (along with LAMP1) is widely accepted as a structural lysosomal membrane protein marker used to identify lysosomes and late endo/lysosomal compartments”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Saftig and Klumperman 2009

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Metadata

Authors
Saftig, P., & Klumperman, J.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2009-08-12
Volume
10
Issue
9
Pages
623-635
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm2745
Cited by
1,648
References
4
Language
en
Licence
www.springer.com/tdm (tdm)

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