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ORAL DRUG THERAPY FOR ERECTILE DYSFUNCTION
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“In addition, in the presence of high-fat food, absorption of sildenafil and vardenafil may be delayed; however, the rate and extent of tadalafil absorption are unaffected by highfat food.”
From Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles (2004) · cites this paper as [6]
In the citing paper
“Administration of sildenafil with a high-fat meal reduces the C max by about 29% 6 (Table I) and delays the time to achieve peak plasma concentration, or T max , by about 1 h.6”
From Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles (2004) · cites this paper as [6]
In the citing paper
“Conversely, tadalafil is a weak inhibitor of PDE6 compared with either sildenafil or vardenafil and may account for the rare occurrence of color vision abnormalities (< 0.1%) with tadalafil.6,7”
From Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles (2004) · cites this paper as [6]
In the citing paper
“For example, sildenafil is a relatively potent inhibitor of PDE6 (localized in the rods and cones of the retina), which may explain the color vision disturbances reported in up to 11% of men receiving sildenafil.6”
From Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles (2004) · cites this paper as [6]
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Citations
Cites
Oral Sildenafil in the Treatment of Erectile Dysfunction
Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382001 · Cited by 2,120
Self-citation
Research works printed but not linked: 32
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- Cheitlin, 1999, Use of sildenafil (Viagra) in patients with cardiovascular disease, J Am Coll Cardiol, 33, 273, 10.1016/S0735-1097(98)00656-1 · DOI · Paper page
- Conti, 1999, Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease, Am J Cardiol, 83, 29C, 10.1016/S0002-9149(99)00045-4 · DOI
- R DeBusk, Y Drory, I Goldstein, et al, Management of sexual dysfunction in patients with cardiovascular diseases: Recommendations of the Princeton Consensus Panel. Am J Cardiol, in press
- Derry, 1998, Efficacy and safety of oral sildenafil in men with erectile dysfunction caused by spinal cord injury, Neurology, 51, 1629, 10.1212/WNL.51.6.1629 · DOI
- Derry, 1997, Sildenafil: A double blind placebo controlled single dose 2-way crossover study in men with erectile dysfunction caused by traumatic spinal cord injury, J Urol, 157, 181
- Duncker, 1995, Nitrovasodilators ITF 296 and isosorbide dinitrate exert anti-ischemic activity by dilating coronary penetrating arteries, J Cardiovasc Pharmacol, 25, 823, 10.1097/00005344-199505000-00020 · DOI
- Fugl-Meyer, 1997, On life satisfaction in male erectile dysfunction, Int J Impot Res, 9, 141, 10.1038/sj.ijir.3900269 · DOI · Paper page
- Herrmann, 2000, Hemodynamic effects of sildenafil in men with severe coronary artery disease, N Engl J Med, 342, 1622, 10.1056/NEJM200006013422201 · DOI · Paper page
- Holmgren, 1998, Sildenafil in the treatment of erectile dysfunction caused by spinal cord injury: A double blind placebo controlled flexible dose 2-way crossover study, Neurology, 50, A127
- Ishibashi, 1997, The nitric oxide donor ITF 1129 augments subendocardial blood flow during exercise-induced myocardial ischemia, J Cardiovasc Pharmacol, 30, 374, 10.1097/00005344-199709000-00016 · DOI
- Jackson, 1999, Effects of sildenafil citrate on human hemodynamics, Am J Cardiol, 83, 13C, 10.1016/S0002-9149(99)00043-0 · DOI · Paper page
- SD Katz, K Balidemaj, S Homma, et al. Acute type 5 phosphodiesterase inhibition with sildenafil enhances endothelium-dependent, flow-mediated vasodilation in patients with chronic heart failure [abstract 500082]. In Programs and Abstracts of the American Heart Association Annual Meeting, Annaheim, CA, 2000. · DOI · Paper page
- Lue, 2000, Drug therapy: Erectile dysfunction, N Engl J Med, 342, 1802, 10.1056/NEJM200006153422407 · DOI · Paper page
- Melis, 1996, Dopamine agonists increase nitric oxide production in the paraventricular nucleus of the hypothalamus: Correlation in penile erection and yawning, Eur J Neurosci, 8, 2056, 10.1111/j.1460-9568.1996.tb00725.x · DOI
- Mittleman, 2000, Incidence of myocardial infarction and death in 53 clinical trials of Viagra (sildenafil citrate), J Am Coll Cardiol, 35, 302A
- Morales, 1998, Clinical safety of sildenafil citrate (Viagra) in the treatment of erectile dysfunction, Int J Impot Res, 10, 69, 10.1038/sj.ijir.3900354 · DOI · Paper page
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- Padma-Nathan, 1998, A 24-week, fixed-dose study to assess the efficacy and safety of sildenafil (Viagra) in men with erectile dysfunction, J Urol, 159, 238A
- Padma-Nathan, 1998, Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction: A double blind, placebo-controlled study of 329 patients, Int J Clin Pract, 52, 1, 10.1111/j.1742-1241.1998.tb08886.x · DOI
- H adma-Nathan, RC Rosen, RW Lewis, et al.Sublingual apomorphine for the treatment of male erectile dysfunction. (in press)
- Price, 1997, Sildenafil, A novel oral therapy for penile erectile dysfunction in patients with diabetes, Diabet Med, 14, A6
- Rendell, 1999, Sildenafil for the treatment of erectile dysfunction in men with diabetes, JAMA, 281, 421, 10.1001/jama.281.5.421 · DOI
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- Steers, 1998, Meta-analysis of the efficacy of sildenafil (Viagra) in the treatment of severe erectile dysfunction, J Urol, 159, 238A
- Steif, 2000, The effect of sildenafil on cAMP levels in human cardiac tissue: A possible explanation for cardiovascular side effects, J Am Coll Cardiol, 35
- Wagner, 1998, Analysis of the efficacy of sildenafil (Viagra) in the treatment of male erectile dysfunction in elderly patients, J Urol, 159, 238A
- Webb, 1999, Sildenafil citrate and blood-pressure lowering drugs: Results of drug interaction studies with organic nitrate and a calcium antagonist, Am J Cardiol, 83, 21C, 10.1016/S0002-9149(99)00044-2 · DOI · Paper page
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Cited by
Dopamine and serotonin: influences on male sexual behavior
Hull, E. M., Muschamp, J. W., & Sato, S. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.018 · Cited by 465
PHARMACOLOGY OF PHOSPHODIESTERASE‐5 INHIBITORS
Corbin, J., & Francis, S. (2002) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2002.tb11296.x · Cited by 260
Seftel, A. D. (2004) · Clinical Cardiology · doi:10.1002/clc.4960271305 · Cited by 79
Tadalafil: a novel treatment for erectile dysfunction
GIULIANO, F. (2002) · European Heart Journal Supplements · doi:10.1016/s1520-765x(02)90049-0 · Cited by 21
Self-citation
Metadata
- Authors
- Padma-Nathan, H., & Giuliano, F.
- Venue
- Urologic Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 28
- Issue
- 2
- Pages
- 321-334
- ISSN
- 0094-0143
- Cited by
- 77
- References
- 1
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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- Padma-Nathan, H., & Giuliano, F. (2001). ORAL DRUG THERAPY FOR ERECTILE DYSFUNCTION. Urologic Clinics of North America. https://doi.org/10.1016/s0094-0143(05)70141-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
