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Population stratification and spurious allelic association
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Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
Use of Unlinked Genetic Markers to Detect Population Stratification in Association Studies
Pritchard, J. K., & Rosenberg, N. A. (1999) · The American Journal of Human Genetics · doi:10.1086/302449 · Cited by 1,198
Candidate-gene approaches for studying complex genetic traits: practical considerations
Tabor, H. K., Risch, N. J., & Myers, R. M. (2002) · Nature Reviews Genetics · doi:10.1038/nrg796 · Cited by 1,076
Large Upward Bias in Estimation of Locus-Specific Effects from Genomewide Scans
Göring, H. H. H., Terwilliger, J. D., & Blangero, J. (2001) · The American Journal of Human Genetics · doi:10.1086/324471 · Cited by 483
Risch, N., & Teng, J. (1998) · Genome Research · doi:10.1101/gr.8.12.1273 · Cited by 366
Bacanu, S.-A., Devlin, B., & Roeder, K. (2000) · The American Journal of Human Genetics · doi:10.1086/302929 · Cited by 340
Research works printed but not linked: 80
- Wilson, 2001, Diabetes mellitus and coronary heart disease, Endocrinol Metab Clin North Am, 30, 857, 10.1016/S0889-8529(05)70219-X · DOI
- Weiss, 2001, The health economics of asthma and rhinitis: I—assessing the economic impact, J Allergy Clin Immunol, 107, 3, 10.1067/mai.2001.112262 · DOI · Paper page
- Drews, 1997, The role of innovation in drug development, Nat Biotechnol, 15, 1318, 10.1038/nbt1297-1318 · DOI
- Roses, 2000, Pharmacogenetics and the practice of medicine, Nature, 405, 857, 10.1038/35015728 · DOI · Paper page
- Palmer, 2000, Genomic approaches to understanding asthma, Genome Res, 10, 1280, 10.1101/gr.143400 · DOI
- McCarthy, 2002, Susceptibility gene discovery for common metabolic and endocrine traits, J Mol Endocrinol, 28, 1, 10.1677/jme.0.0280001 · DOI
- Cardon, 2001, Association study designs for complex diseases, Nat Rev Genet, 2, 91, 10.1038/35052543 · DOI
- Lander, 2001, Initial sequencing and analysis of the human genome, Nature, 409, 860, 10.1038/35057062 · DOI · Paper page
- Collins, 1997, Variations on a theme: cataloging human DNA sequence variation, Science, 278, 1580, 10.1126/science.278.5343.1580 · DOI · Paper page
- Sachidanandam, 2001, A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms, Nature, 409, 928, 10.1038/35057149 · DOI · Paper page
- Riboli, 1992, Nutrition and cancer: background and rationale of the European Prospective Investigation into Cancer and Nutrition (EPIC), Ann Oncol, 3, 783, 10.1093/oxfordjournals.annonc.a058097 · DOI · Paper page
- 1986, Randomised trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction, Lancet, 2, 57
- 1999, Design and characteristics of the study population, Breast Cancer Res, 1, 73, 10.1186/bcr16 · DOI
- Clayton, 2001, Epidemiological methods for studying genes and environmental factors in complex diseases, Lancet, 358, 1356, 10.1016/S0140-6736(01)06418-2 · DOI · Paper page
- Radda, 2002, The need for independent scientific peer review of Biobank UK, Lancet, 359, 2282, 10.1016/S0140-6736(02)09289-9 · DOI
- Wallace, 2002, The need for independent scientific peer review of Biobank UK, Lancet, 359, 2282, 10.1016/S0140-6736(02)09289-9 · DOI
- Wright, 2002, Gene-environment interactions: the BioBank UK study, Pharm J, 2, 75
- Wang, 1998, Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome, Science, 280, 1077, 10.1126/science.280.5366.1077 · DOI
- Slatkin, 1991, Inbreeding coefficients and coalescence times, Genet Res, 58, 167, 10.1017/S0016672300029827 · DOI · Paper page
- Goddard, 2000, Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations, Am J Hum Genet, 66, 216, 10.1086/302727 · DOI
- Stephens, 2001, Haplotype variation and linkage disequilibrium in 313 human genes, Science, 293, 489, 10.1126/science.1059431 · DOI · Paper page
- Wacholder, 2000, Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias, J Natl Cancer Inst, 92, 1151, 10.1093/jnci/92.14.1151 · DOI · Paper page
- Chakraborty, 1988, Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci, Proc Natl Acad Sci USA, 85, 9119, 10.1073/pnas.85.23.9119 · DOI · Paper page
- Stephens, 1994, Mapping by admixture linkage disequilibrium in human populations: limits and guidelines, Am J Hum Genet, 55, 809
- McKeigue, 1997, Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations, Am J Hum Genet, 60, 188
- McKeigue, 1998, Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture, Am J Hum Genet, 63, 241, 10.1086/301908 · DOI
- McKeigue, 2000, Estimation of admixture and detection of linkage in admixed populations by a Bayesian approach: application to African-American populations, Ann Hum Genet, 64, 171, 10.1046/j.1469-1809.2000.6420171.x · DOI
- Weiss, 2000, How many diseases does it take to map a gene with SNPs?, Nat Genet, 26, 151, 10.1038/79866 · DOI
- Terwilliger, 2000, Gene mapping in the 20th and 21st centuries: statistical methods, data analysis, and experimental design, Hum Biol, 72, 63
- Anon, 1999, Freely associating, Nat Genet, 22, 1, 10.1038/8702 · DOI · Paper page
- Gauderman, 1999, Family-based association studies, J Natl Cancer Inst Monogr, 26, 31, 10.1093/oxfordjournals.jncimonographs.a024223 · DOI
- Risch, 1996, The future of genetic studies of complex human diseases, Science, 273, 1516, 10.1126/science.273.5281.1516 · DOI · Paper page
- Morton, 1998, Tests and estimates of allelic association in complex inheritance, Proc Natl Acad Sci USA, 95, 11389, 10.1073/pnas.95.19.11389 · DOI
- Silverman, 2000, Case-control association studies for the genetics of complex respiratory diseases, Am J Respir Cell Mol Biol, 22, 645, 10.1165/ajrcmb.22.6.f191 · DOI
- Witte, 1999, Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs, Am J Epidemiol, 149, 693, 10.1093/oxfordjournals.aje.a009877 · DOI
- Teng, 1999, The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases, II: individual genotyping, Genome Res, 9, 234, 10.1101/gr.9.3.234 · DOI
- Ioannidis, 2001, Replication validity of genetic association studies, Nat Genet, 29, 306, 10.1038/ng749 · DOI
- Jorde, 2000, Linkage disequilibrium and the search for complex disease genes, Genome Res, 10, 1435, 10.1101/gr.144500 · DOI · Paper page
- Knowler, 1988, Gm3;5,13,14 and type 2 diabetes mellitus: an association in American Indians with genetic admixture, Am J Hum Genet, 43, 520
- Gelernter, 1993, The A1 allele at the D2 dopamine receptor gene and alcoholism: a reappraisal, JAMA, 269, 1673, 10.1001/jama.1993.03500130087038 · DOI · Paper page
- Pato, 1993, Review of the putative association of dopamine D2 receptor and alcoholism: a meta-analysis, Am J Med Genet, 48, 78, 10.1002/ajmg.1320480204 · DOI
- Zondervan, 2002, What makes a good case-control study? Design issues for complex traits such as endometriosis, Hum Reprod, 17, 1415, 10.1093/humrep/17.6.1415 · DOI · Paper page
- Ardlie, 2002, Testing for population subdivision and association in four case-control studies, Am J Hum Genet, 71, 304, 10.1086/341719 · DOI
- Martin, 2001, Assessment of stratification in linkage and association samples, Am J Hum Genet, 69, 419
- Pankow, 2001, Little evidence for bias due to population stratification in a population-based study of non-Hispanic Blacks and Whites, Am J Hum Genet, 69, 412
- Cutler, 2001, Human population substructure and its influence on association studies, Am J Hum Genet, 69, 181
- Carvajal-Carmona, 2001, Genetic diversity and population structure of two historically related Latin-American populations, Am J Hum Genet, 69, 418
- Yamada, 2001, Analysis of population structure of Japanese population using genotype data of genome wide hundreds of SNPs, Am J Hum Genet, 69, 423
- Hill, 2001, DNA pooling, genome control and association studies, Am J Hum Genet, 69, 423
- Pritchard, 2001, Case-control studies of association in structured or admixed populations, Theor Popul Biol, 60, 227, 10.1006/tpbi.2001.1543 · DOI · Paper page
- Weeks, 1995, Polygenic disease: methods for mapping complex disease traits, Trends Genet, 11, 513, 10.1016/S0168-9525(00)89163-5 · DOI
- Wilson, 2001, Population genetic structure of variable drug response, Nat Genet, 29, 265, 10.1038/ng761 · DOI
- Schulze, 2002, Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines, Am J Med Genet, 114, 1, 10.1002/ajmg.10042 · DOI
- Abecasis, 2000, Pedigree tests of transmission disequilibrium, Eur J Hum Genet, 8, 545, 10.1038/sj.ejhg.5200494 · DOI
- Spielman, 1993, Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM), Am J Hum Genet, 52, 506
- Ewens, 1995, The transmission/disequilibrium test: history, subdivision, and admixture, Am J Hum Genet, 57, 455
- McGinnis, 2002, Power and efficiency of the TDT and case-control design for association scans, Behav Genet, 32, 135, 10.1023/A:1015205924326 · DOI
- Nielsen, 2001, Association studies under general disease models, Theor Popul Biol, 60, 253, 10.1006/tpbi.2001.1539 · DOI
- Gordon, 2001, A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data, Am J Hum Genet, 69, 371, 10.1086/321981 · DOI
- Kirk, 2002, The impact of genotyping error on haplotype reconstruction and frequency estimation, Eur J Hum Genet, 10, 616, 10.1038/sj.ejhg.5200855 · DOI
- Devlin, 2001, Genomic control, a new approach to genetic-based association studies, Theor Popul Biol, 60, 155, 10.1006/tpbi.2001.1542 · DOI · Paper page
- Devlin, 2001, Unbiased methods for population-based association studies, Genet Epidemiol, 21, 273, 10.1002/gepi.1034 · DOI
- Bacanu, 2002, Association studies for quantitative traits in structured populations, Genet Epidemiol, 22, 78, 10.1002/gepi.1045 · DOI
- Reich, 2001, Detecting association in a case-control study while correcting for population stratification, Genet Epidemiol, 20, 4, 10.1002/1098-2272(200101)20:1<4::AID-GEPI2>3.0.CO;2-T · DOI
- Pritchard, 2000, Inference of population structure using multilocus genotype data, Genetics, 155, 945, 10.1093/genetics/155.2.945 · DOI · Paper page
- Pritchard, 2000, Association mapping in structured populations, Am J Hum Genet, 67, 170, 10.1086/302959 · DOI · Paper page
- Satten, 2001, Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model, Am J Hum Genet, 68, 466, 10.1086/318195 · DOI
- Thornsberry, 2001, Dwarf8 polymorphisms associate with variation in flowering time, Nat Genet, 28, 286, 10.1038/90135 · DOI · Paper page
- Jiang, 2001, When is the bias caused by population stratification negligible?, Am J Hum Genet, 69, 409
- Deng, 2001, Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits, Genetics, 159, 1319, 10.1093/genetics/159.3.1319 · DOI
- Roses, 2000, Pharmacogenetics and future drug development and delivery, Lancet, 355, 1358, 10.1016/S0140-6736(00)02126-7 · DOI
- Ball, 1997, Pharmacogenetics and drug metabolism, Nat Biotechnol, 15, 925, 10.1038/nbt1097-925 · DOI
- Poolsup, 2000, Pharmacogenetics and psychopharmacotherapy, J Clin Pharm Ther, 25, 197, 10.1046/j.1365-2710.2000.00281.x · DOI
- McCarthy, 2000, The use of single-nucleotide polymorphism maps in pharmacogenomics, Nat Biotechnol, 18, 505, 10.1038/75360 · DOI · Paper page
- March, 2000, Pharmacogenomics: the genomics of drug response, Yeast, 17, 16, 10.1002/(SICI)1097-0061(200004)17:1<16::AID-YEA6>3.0.CO;2-E · DOI
- Palmer, 2002, Pharmacogenetics of asthma, Am J Respir Crit Care Med, 165, 861, 10.1164/ajrccm.165.7.2109096 · DOI
- Pettipher, 2002, The application of genetics to the discovery of better medicines, Pharmacogenomics, 3, 257, 10.1517/14622416.3.2.257 · DOI
- McLeod, 2001, Pharmacogenetics: more than skin deep, Nat Genet, 29, 247, 10.1038/ng1101-247 · DOI
- Walker, 2001, Biology and genetics of colorectal cancer, Eur J Cancer, 37, S163, 10.1016/S0959-8049(01)80018-6 · DOI
- Overall, 2001, A method for distinguishing consanguinity and population substructure using multilocus genotype data, Mol Biol Evol, 18, 2048, 10.1093/oxfordjournals.molbev.a003746 · DOI
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Metadata
- Authors
- Cardon, L. R., & Palmer, L. J.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 361
- Issue
- 9357
- Pages
- 598-604
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2120483845
- Cited by
- 1,204
- References
- 7
- FWCI
- 57.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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