Cited by 1,076Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsHealth, Environment, Cognitive Aging

Candidate-gene approaches for studying complex genetic traits: practical considerations

Tabor, Holly K., Risch, Neil J., Myers, Richard M.·2002·Nature Reviews Genetics

Abstract

Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of non-replication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation.

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Crossref · 10.1038/nrg796

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Authors
Tabor, H. K., Risch, N. J., & Myers, R. M.
Affiliations
  • Stanford Medicine (US)
  • Kaiser Permanente (US)
Corresponding author
Myers, Richard M.
Venue
Nature Reviews Genetics
Published
2002-05
Volume
3
Issue
5
Pages
391-397
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W1969673534
Cited by
1,076
References
63
Citations by year
2026: 5 · 2025: 12 · 2024: 26 · 2023: 21 · 2022: 24 · 2021: 28 · 2020: 34 · 2019: 36 · 2018: 37 · 2017: 47 · 2016: 40 · 2015: 57 · 2014: 39 · 2013: 54 · 2012: 53
FWCI
8.17
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion, public-domain)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords
candidate gene association, complex traits, complex diseases, replication of results, genetic polymorphism, causal genes, epidemiological principles, genetic epidemiology
MeSH terms
Animals, Humans, Reproducibility of Results, Linkage Disequilibrium, Molecular Epidemiology, Multifactorial Inheritance, Polymorphism, Single Nucleotide

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