The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction
Abstract
The meningococcal serogroup C conjugate (MCC) vaccine programme in England has successfully controlled the incidence of serogroup C disease, as a result of high short-term vaccine effectiveness and substantial herd immunity. However, the long-term effectiveness of the vaccine remains unknown. We assessed surveillance data from the 4 years since introduction of the programme. Vaccine effectiveness remained high in children vaccinated in the catch-up campaign (aged 5 months to 18 years). However, for children vaccinated in the routine infant immunisation programme, the effectiveness of the MCC vaccine fell to low levels after only 1 year. The number of individuals in these cohorts remains low, but alternative routine immunisation schedules should be considered to ensure high levels of protection are sustained.
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“vaccination of children and young adults (up to 19 years of age) with capsular group C meningococcal vaccine in a mass campaign in 1999 resulted in almost complete elimination of disease from the UK in adults as well as children57.”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [57]
Citations
Cites
Miller, E. J., SALISBURY, D. M., & Ramsay, M. E. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00299-7 · Cited by 483
Self-citationHerd immunity from meningococcal serogroup C conjugate vaccination in England: database analysis
Ramsay, M. E., Andrews, N. J., Trotter, C. L., Kaczmarski, E. B., & Miller, E. (2003) · BMJ · doi:10.1136/bmj.326.7385.365 · Cited by 409
Self-citationEfficacy of meningococcal serogroup C conjugate vaccine in teenagers and toddlers in England
Ramsay, M. E., Andrews, N. J., Kaczmarski, E. B., & Miller, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03594-7 · Cited by 337
Self-citationRamsay, M. E., McVernon, J., Andrews, N. J., Heath, P. T., & Slack, M. P. (2003) · The Journal of Infectious Diseases · doi:10.1086/376997 · Cited by 172
Self-citationBorrow, R., Goldblatt, D., Andrews, N. J., Southern, J., Ashton, L., Deane, S., Morris, R., Cartwright, K. A. V., & Miller, E. (2002) · The Journal of Infectious Diseases · doi:10.1086/344324 · Cited by 114
Self-citation
Research works printed but not linked: 1
- Quarterly Communicable Disease Reports on the COVER programme for childhood immunisation
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A guide to vaccinology: from basic principles to new developments
Pollard, A. J., & Bijker, E. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00479-7 · Cited by 1,593
Epidemic meningitis, meningococcaemia, and Neisseria meningitidis
Stephens, D. S., Greenwood, B., & Brandtzaeg, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61016-2 · Cited by 978
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659
Immunisation against infectious disease
SALISBURY, D. M., Ramsay, M. E., & Noakes, K. (2006) · Stationery Office eBooks · Cited by 636
Self-citationBacterial meningitis in children
Sáez‐Llorens, X., & McCracken, G. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13693-8 · Cited by 543
Metadata
- Authors
- Trotter, C. L., Andrews, N. J., Kaczmarski, E. B., Miller, E., & Ramsay, M. E.
- Affiliations
- Manchester Royal Infirmary (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 364
- Issue
- 9431
- Pages
- 365-367
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2160879811
- Cited by
- 571
- References
- 5
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 12 · 2019: 15 · 2018: 18 · 2017: 26 · 2016: 23 · 2015: 33 · 2014: 27 · 2013: 29 · 2012: 42
- FWCI
- 50.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Keywords
- vaccine effectiveness, long-term vaccine effectiveness, herd immunity, catch-up vaccination, meningococcal disease incidence, vaccination schedule, England
- MeSH terms
- Adolescent, Adult, Age Factors, Child, Child, Preschool, England, Follow-Up Studies, Humans, Immunization Schedule, Immunization, Secondary, Infant, Meningococcal Infections, Vaccines, Conjugate, Meningococcal Vaccines, Immunity, Herd, Neisseria meningitidis, Serogroup C
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