B-cell responses to vaccination at the extremes of age
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Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups.
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Ageing is associated with a decline in naïve B cell production, an accumulation of memory B cells with limited specificities, and less robust plasma cell responses to antigen, with the antibodies produced being less effective.
“As with T cells, ageing is associated with a decline in naïve B cell production, an accumulation of memory B cells with limited specificities, and less robust plasma cell responses to antigen, with the antibodies produced being less effective (Siegrist and Aspinall 2009).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Siegrist and Aspinall 2009
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Birjandi, S. Z., Ippolito, J. A., Ramadorai, A. K., & Witte, P. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001271 · Cited by 92 · see citing works
The role of Staphylococcus epidermidis in neonatal sepsis: Guarding angel or pathogenic devil?
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Human respiratory syncytial virus: pathogenesis, immune responses, and current vaccine approaches
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Immune system development varies according to age, location, and anemia in African children
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Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead
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“A vaccine depends on the patient’s immune system to deliver these antibodies, yet the vast majority of patients suffering from neurodegenerative disease are elderly, and their immune system senescent (Siegrist and Aspinall, 2009).”
BackgroundFrom Sharks to Yeasts: Squalene in the Development of Vaccine Adjuvants
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A comprehensive comparison of DNA and RNA vaccines
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Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults
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The next decade of vaccines: societal and scientific challenges
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Self-citationCOVID-19 Vaccines: “Warp Speed” Needs Mind Melds, Not Warped Minds
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Aging affects B‐cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues
Tabibian‐Keissar, H., Hazanov, L., Schiby, G., Rosenthal, N., Rakovsky, A., Michaeli, M., Shahaf, G. L., Pickman, Y., Rosenblatt, K., Melamed, D., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201545586 · Cited by 84 · see citing works
- Authors
- Siegrist, C.-A., & Aspinall, R.
- Affiliations
- University of Geneva (CH)
- Cranfield University (GB)
- Corresponding author
- Siegrist, Claire-Anne
- Venue
- Nature Reviews Immunology
- Published
- 2009-03
- Volume
- 9
- Issue
- 3
- Pages
- 185-194
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2019896390
- Cited by
- 659
- References
- 114
- Citations by year
- 2026: 31 · 2025: 29 · 2024: 37 · 2023: 34 · 2022: 46 · 2021: 59 · 2020: 50 · 2019: 31 · 2018: 32 · 2017: 45 · 2016: 35 · 2015: 33 · 2014: 35 · 2013: 39 · 2012: 32
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- B cell response, vaccination, infants, older adults, immunosenescence, immunodeficiency, antibody response, lymphoid microenvironment, bone marrow, vaccination strategies
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, B-Lymphocytes, Communicable Diseases, Humans, Immunologic Memory, Infant, Infant, Newborn, Vaccination, Vaccines, Mice
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