Cited by 662T-cell and B-cell ImmunologyImmune responses and vaccinationsImmunotherapy and Immune Responses

B-cell responses to vaccination at the extremes of age

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Siegrist, Claire-Anne, Aspinall, Richard·2009·Nature Reviews Immunology

Abstract

Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups.

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  • Ageing is associated with a decline in naïve B cell production, an accumulation of memory B cells with limited specificities, and less robust plasma cell responses to antigen, with the antibodies produced being less effective.

    “As with T cells, ageing is associated with a decline in naïve B cell production, an accumulation of memory B cells with limited specificities, and less robust plasma cell responses to antigen, with the antibodies produced being less effective (Siegrist and Aspinall 2009).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Siegrist and Aspinall 2009

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Authors
Siegrist, C.-A., & Aspinall, R.
Affiliations
  • University of Geneva (CH)
  • Cranfield University (GB)
Corresponding author
Siegrist, Claire-Anne
Venue
Nature Reviews Immunology
Published
2009-03
Volume
9
Issue
3
Pages
185-194
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2019896390
Cited by
659
References
114
Citations by year
2026: 31 · 2025: 29 · 2024: 37 · 2023: 34 · 2022: 46 · 2021: 59 · 2020: 50 · 2019: 31 · 2018: 32 · 2017: 45 · 2016: 35 · 2015: 33 · 2014: 35 · 2013: 39 · 2012: 32
FWCI
3.18
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
B cell response, vaccination, infants, older adults, immunosenescence, immunodeficiency, antibody response, lymphoid microenvironment, bone marrow, vaccination strategies
MeSH terms
Aged, Aged, 80 and over, Aging, Animals, B-Lymphocytes, Communicable Diseases, Humans, Immunologic Memory, Infant, Infant, Newborn, Vaccination, Vaccines, Mice

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