Cited by 289Venous Thromboembolism Diagnosis and ManagementBlood Coagulation and Thrombosis MechanismsCerebral Venous Sinus Thrombosis

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Effect of patient's sex on risk of recurrent venous thromboembolism: a meta-analysis.

McRae, Simon, Tran, Huyen, Schulman, Sam, Ginsberg, Jeff, Kearon, Clive·2006·The Lancet

DOI 10.1016/s0140-6736(06)69110-1

Open this paper in CoChat — free account

Abstract

Background Individual risk of recurrent venous thromboembolism affects patient management and might differ between men and women. We did a meta-analysis to assess from available evidence whether men and women have the same risk of recurrent venous thromboembolism after stopping anticoagulant treatment.Methods Eligible articles were identified by searches of MEDLINE (source PubMed, 1966 to February 2005), EMBase (1980 to February 2005), and the Cochrane database 2005, issue 1. Prospective cohort studies and randomised trials were eligible if they included patients with objectively diagnosed venous thromboembolism treated for a minimum of 1 month and followed up for recurrence after anticoagulant treatment was stopped. Data were extracted for study design, study quality, and the number, sex, and age of enrolled patients, risk factors for venous thromboembolism, treatment given, duration of follow-up, and the number of episodes of recurrent venous thrombosis.Findings 15 studies (nine randomised controlled trials and six prospective observational studies) enrolling a total of 5416 individuals (2729 men), of whom 816 (523 men) had recurrent venous thromboembolism after stopping treatment, were eligible for inclusion. The pooled estimate of the relative risk (RR) of recurrent venous thromboembolism for men compared with for women was 1.6 (95% CI 1.2-2.0). Significant heterogeneity was shown among individual study findings; however, the higher risk of recurrent venous thromboembolism in men than in women was consistent across predefined subgroups. The relative risk for recurrence in men from randomised trials (RR 1.3; 95% CI 1.0-1.8) was lower than that from observational studies (2.1; 1.5-2.9). The lower risk of recurrent venous thromboembolism in women did not seem to be accounted for by a reduced rate of recurrence after venous thromboembolism associated with oestrogen treatment or pregnancy.Interpretation Men seem to have a 50% higher risk than women of recurrent venous thromboembolism after stopping anticoagulant treatment. If confirmed by further prospective studies, this difference in risk of recurrence should be considered when duration of anticoagulant treatment is determined in individual patients.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(06)69110-1

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
The Epidemiology of Venous Thromboembolism
White, R. H. R. (2003) · Circulation · doi:10.1161/01.cir.0000078468.11849.66 · Cited by 2,304
The Long-Term Clinical Course of Acute Deep Venous Thrombosis
Prandoni, P., Lensing, A. W. A., Cogo, A., Cuppini, S., Villalta, S., Carta, M., Cattelan, A. M., Polistena, P., Bernardi, E., & Prins, M. H. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-125-1-199607010-00001 · Cited by 2,094
Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis
Prandoni, P., Lensing, A. W. A., Piccioli, A., Bernardi, E., Simioni, P., Girolami, B., Marchiori, A., Sabbion, P., Prins, M. H., Noventa, F., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0108 · Cited by 1,863
Incidence of Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Embolism
Pengo, V., Lensing, A. W. A., Prins, M. H., Marchiori, A., Davidson, B. L., Tiozzo, F., Albanese, P., Biasiolo, A., Pegoraro, C., Iliceto, S., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032274 · Cited by 1,828
Predictors of Recurrence After Deep Vein Thrombosis and Pulmonary Embolism
Heit, J. A., Mohr, D. N., Silverstein, M. D., Petterson, T. M., O’Fallon, W. M., & Melton, L. J. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.6.761 · Cited by 1,348
Users' guides to the medical literature : a manual for evidence-based clinical practice
Guyatt, G. H., Rennie, D., Meade, M. O., & Cook, D. J. (2002) · Cited by 1,196
Treatment of Venous Thrombosis with Intravenous Unfractionated Heparin Administered in the Hospital as Compared with Subcutaneous Low-Molecular-Weight Heparin Administered at Home
Koopman, M. M. W., Prandoni, P., Piovella, F., Ockelford, P., Brandjes, D. P. M., van der Meer, J., Gallus, A. S., Simonneau, G., Chesterman, C., Prins, M. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603143341102 · Cited by 1,105
A Comparison of Three Months of Anticoagulation with Extended Anticoagulation for a First Episode of Idiopathic Venous Thromboembolism
Kearon, C., Gent, M., Hirsh, J., Weitz, J. I., Kovacs, M. J., Anderson, D. R., Turpie, A. G. G., Green, D., Ginsberg, J. S., Wells, P. S., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903253401201 · Cited by 1,057
A Comparison of Six Weeks with Six Months of Oral Anticoagulant Therapy after a First Episode of Venous Thromboembolism
Schulman, S., Rhedin, A.-S., Lindmarker, P., Carlsson, A., Lärfars, G., Nicol, P., Loogna, E., Svensson, E., Ljungberg, B., Walter, H., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506223322501 · Cited by 932

Show all 37 references

Sorted by citations

Untitled work
Kearon (2012) · doi:10.1378/chest.11-2301 · Cited by 6,119
Antithrombotic Therapy for VTE Disease
Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., et al. (2016) · Chest · doi:10.1016/j.chest.2015.11.026 · Cited by 4,830
Antithrombotic Therapy for Venous Thromboembolic Disease
Kearon, C., Kahn, S. R., Agnelli, G., Goldhaber, S. Z., Raskob, G. E., & Comerota, A. J. (2008) · CHEST Journal · doi:10.1378/chest.08-0658 · Cited by 1,992
Epidemiology of venous thromboembolism
Heit, J. A. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.83 · Cited by 1,277
The epidemiology of venous thromboembolism
Heit, J. A., Spencer, F. A., & White, R. H. R. (2016) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-015-1311-6 · Cited by 1,142
The Epidemiology of Venous Thromboembolism in the Community
Heit, J. A. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.162545 · Cited by 774
The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients
Prandoni, P., Noventa, F., Ghirarduzzi, A., Pengo, V., Bernardi, E., Pesavento, R., Iotti, M., Tormene, D., Simioni, P., & Pagnan, A. (2007) · Haematologica · doi:10.3324/haematol.10516 · Cited by 776
Epidemiology and Risk Factors for Venous Thrombosis
Cushman, M. (2007) · Seminars in Hematology · doi:10.1053/j.seminhematol.2007.02.004 · Cited by 760
Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy
Rodger, M. A., Kahn, S. R., Wells, P. S., Anderson, D. A., Chagnon, I., Le Gal, G., Solymoss, S., Crowther, M., Perrier, A., White, R., et al. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.080493 · Cited by 581
Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study
Pengo, V., Ruffatti, A., Legnani, C., Testa, S., Fierro, T., Marongiu, F., De Micheli, V., Gresele, P., Tonello, M., Ghirarduzzi, A., et al. (2011) · Blood · doi:10.1182/blood-2011-03-340232 · Cited by 468
Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH)
Tosetto, A., Iorio, A., Marcucci, M., Baglin, T. P., Cushman, M., Eichinger, S., Palareti, G., Poli, D., Tait, R. C., & Douketis, J. D. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2012.04735.x · Cited by 446
Extended-Duration Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients With Recently Reduced Mobility
Hull, R. D., Schellong, S., Tapson, V. F., Monréal, M., Samama, M., Nicol, P., Vicaut, É., Turpie, A. G. G., & Yusen, R. D. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-1-201007060-00004 · Cited by 400
Superficial Venous Thrombosis and Venous Thromboembolism
Decousus, H., Quéré, I., Presles, É., Becker, F., Barrellier, M. ‐., Chanut, M., Gillet, J.-L., Guenneguez, H., Leandri, C., Mismetti, P., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-4-201002160-00006 · Cited by 350
Functional and Exercise Limitations After a First Episode of Pulmonary Embolism
Kahn, S. R., Hirsch, A. M., Akaberi, A., Hernandez, P., Anderson, D. R., Wells, P. S., Rodger, M. A., Solymoss, S., Kovacs, M. J., Rudski, L., et al. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.11.030 · Cited by 286
Duration of anticoagulant therapy for deep vein thrombosis and pulmonary embolism
Kearon, C., & Akl, E. A. (2014) · Blood · doi:10.1182/blood-2013-12-512681 · Cited by 282
Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysis
Douketis, J., Tosetto, A., Marcucci, M., Baglin, T., Cosmi, B., Cushman, M., Kyrle, P., Poli, D., Tait, R. C., & Iorio, A. (2011) · BMJ · doi:10.1136/bmj.d813 · Cited by 278
Systematic Review: d -Dimer to Predict Recurrent Disease after Stopping Anticoagulant Therapy for Unprovoked Venous Thromboembolism
Verhovsek, M. M., Douketis, J. D., Yi, Q., Shrivastava, S., Tait, R. C., Baglin, T. P., Poli, D., & Lim, W. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-7-200810070-00008 · Cited by 268
Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism
Novacek, G., Weltermann, A., Sobala, A., Tilg, H., Petritsch, W., Reinisch, W., Mayer, A., Haas, T., Kaser, A., Feichtenschlager, T., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.026 · Cited by 265
Risk assessment for recurrent venous thrombosis
Kyrle, P. A., Rosendaal, F. R., & Eichinger, S. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60962-2 · Cited by 266
Risk factors for venous thrombosis – current understanding from an epidemiological point of view
Lijfering, W. M., Rosendaal, F. R., & Cannegieter, S. C. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08206.x · Cited by 214
Venous Thromboembolism
Zhu, T., Martinez, I., & Emmerich, J. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.182428 · Cited by 212
Incidence of venous thromboembolism in Korea: from the Health Insurance Review and Assessment Service database
Jang, M. J., Bang, S.-M., & Oh, D. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04108.x · Cited by 191
D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: a management study
Palareti, G., Cosmi, B., Legnani, C., Antonucci, E., Micheli, V. D., Ghirarduzzi, A., Poli, D., Testa, S., Tosetto, A., Pengo, V., et al. (2014) · Blood · doi:10.1182/blood-2014-01-548065 · Cited by 191
Prevention and Treatment of Venous Thromboembolism
Nicolaides, A. N., Fareed, J., Kakkar, A. K., Comerota, A. J., Goldhaber, S. Z., Hull, R. D., Myers, K. A., Samama, M. M., Fletcher, J., Kalodiki, E., et al. (2013) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029612474840 · Cited by 187
Healthcare Disparities in Critical Illness
Soto, G. J., Martin, G. S., & Gong, M. N. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182a84a43 · Cited by 166
Differential risks in men and women for first and recurrent venous thrombosis: the role of genes and environment
Roach, R. E. J., Cannegieter, S. C., & Lijfering, W. M. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12678 · Cited by 153
Inherited risk factors for venous thromboembolism
Martinelli, I., Stefano, V. D., & Mannucci, P. M. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.211 · Cited by 151
Sex Difference in Risk of Second but Not of First Venous Thrombosis
Roach, R. E. J., Lijfering, W. M., Rosendaal, F. R., Cannegieter, S. C., & le Cessie, S. (2013) · Circulation · doi:10.1161/circulationaha.113.004768 · Cited by 150
d -Dimer Testing to Select Patients With a First Unprovoked Venous Thromboembolism Who Can Stop Anticoagulant Therapy
Kearon, C., Spencer, F. A., O’Keeffe, D., Parpia, S., Schulman, S., Baglin, T. P., Stevens, S. M., Kaatz, S. S., Bauer, K. A., Douketis, J. D., et al. (2015) · Annals of Internal Medicine · doi:10.7326/m14-1275 · Cited by 144
High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin
Brouwer, J.-L., Lijfering, W. M., ten Kate, M. K., Kluin‐Nelemans, H. C., Veeger, N. J. G. M., & van der Meer, J. (2008) · Thrombosis and Haemostasis · doi:10.1160/th08-06-0364 · Cited by 142
New guidelines from the Thrombosis and Haemostasis Society of Australia and New Zealand for the diagnosis and management of venous thromboembolism
Tran, H. A., Gibbs, H. H., Merriman, E., Curnow, J. L., Young, L., Bennett, A., Tan, C.-W., Chunilal, S. D., Ward, C., Baker, R. I., et al. (2019) · The Medical Journal of Australia · doi:10.5694/mja2.50004 · Cited by 140
D-Dimer Assays in Diagnosis and Management of Thrombotic and Bleeding Disorders
Bates, S. M. (2012) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0032-1326782 · Cited by 130
Hormone therapy and recurrence of venous thromboembolism among postmenopausal women
Olié, V., Plu‐Bureau, G., Conard, J., Horellou, M., Canonico, M., & Scarabin, P. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181f9f7c3 · Cited by 122
Venous Thromboembolic Events After Cerebral Vein Thrombosis
Miranda, B., Ferro, J. M., Canhão, P., Stam, J., Bousser, M., Barinagarrementería, F., Scoditti, U., & the ISCVT Investigators (2010) · Stroke · doi:10.1161/strokeaha.110.581223 · Cited by 118
Predicting the risk of venous thromboembolism recurrence
Heit, J. A. (2012) · American Journal of Hematology · doi:10.1002/ajh.23128 · Cited by 115
Long-term treatment of venous thromboembolism
Kearon, C., & Kahn, S. R. (2020) · Blood · doi:10.1182/blood.2019002364 · Cited by 113
Sex difference in risk of recurrent venous thrombosis and the risk profile for a second event
Christiansen, S. C., Lijfering, W. M., Helmerhorst, F. M., Rosendaal, F. R., & Cannegieter, S. C. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03994.x · Cited by 108
The role of ethnicity, age and gender in venous thromboembolism
Montagnana, M., Favaloro, E. J., Franchini, M., Guidi, G. C., & Lippi, G. (2009) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-009-0365-8 · Cited by 107
Active Tuberculosis and Venous Thromboembolism: Association According to International Classification of Diseases, Ninth Revision Hospital Discharge Diagnosis Codes
Dentan, C., Épaulard, O., Seynaeve, D., Genty, C., & Bosson, J. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit780 · Cited by 85
Systematic review of prognostic models for recurrent venous thromboembolism (VTE) post-treatment of first unprovoked VTE
Ensor, J., Riley, R. D., Moore, D., Snell, K. I. E., Bayliss, S., & Fitzmaurice, D. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011190 · Cited by 84
The long‐term recurrence risk of patients with unprovoked venous thromboembolism: an observational cohort study
Kyrle, P. A., Kammer, M., Eischer, L., Weltermann, A., Minar, E., Hirschl, M., Heinze, G., & Eichinger, S. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13524 · Cited by 84
Sex Disparities in Efficacy in COVID-19 Vaccines: A Systematic Review and Meta-Analysis
Bignucolo, A., Scarabel, L., Mezzalira, S., Polesel, J., Cecchin, E., & Toffoli, G. (2021) · Vaccines · doi:10.3390/vaccines9080825 · Cited by 88
Thrombophilia screening revisited: an issue of personalized medicine
Colucci, G., & Tsakiris, D. Α. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02090-y · Cited by 85
Management of venous thromboembolic diseases and the role of thrombophilia testing: summary of NICE guidance
Chong, L., Fenu, E., Stansby, G. P., Hodgkinson, S., & on behalf of the Guideline Development Group (2012) · BMJ · doi:10.1136/bmj.e3979 · Cited by 76
Sex Differences in Patients Receiving Anticoagulant Therapy for Venous Thromboembolism
Blanco-Molina, Á., Enea, I., Gadelha, T., Tufano, A., Bura-Rivière, A., Micco, P. D., Bounameaux, H., González, J., Villalta, J., & Monréal, M. (2014) · Medicine · doi:10.1097/md.0000000000000114 · Cited by 74
Prevalence of thrombophilia according to age at the first manifestation of venous thromboembolism: results from the MAISTHRO registry
Weingarz, L., Schwonberg, J., Schindewolf, M., Hecking, C., Wolf, Z., Erbe, M., Weber, A., Lindhoff‐Last, E., & Linnemann, B. (2013) · British Journal of Haematology · doi:10.1111/bjh.12575 · Cited by 70
Treatment of DVT: how long is enough and how do you predict recurrence
Agnelli, G., & Becattini, C. (2007) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-007-0103-z · Cited by 70
Risk of recurrent venous thromboembolism after a first oestrogen-associated episode
Gal, G. L., Kovacs, M. J., Carrier, M., Do, K., Kahn, S. R., Wells, P., Anderson, D. R., Chagnon, I., Solymoss, S., Crowther, M. A., et al. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-10-0685 · Cited by 68
Prothrombotic Fibrin Clot Phenotype Is Associated With Recurrent Pulmonary Embolism After Discontinuation of Anticoagulant Therapy
Ząbczyk, M., Plens, K., Wojtowicz, W., & Undas, A. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308253 · Cited by 66
Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns
Wong, J. H., Dukes, J. W., Levy, R. E., Sos, B. C., Mason, S. E., Fong, T. S., & Weiss, E. J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34957 · Cited by 65
Sex, thrombosis and inherited thrombophilia
Bleker, S. M., Coppens, M., & Middeldorp, S. (2014) · Blood Reviews · doi:10.1016/j.blre.2014.03.005 · Cited by 67
Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update
Akrivou, D., Perlepe, G., Kirgou, P., Gourgoulianis, K. I., & Malli, F. (2022) · Medicina · doi:10.3390/medicina58081078 · Cited by 65
A risk score for prediction of recurrence in patients with unprovoked venous thromboembolism (DAMOVES)
Franco‐Moreno, A., Navarro, M. J. G., Sánchez, J. O., Díaz, R. M. M., Cerezo, E. M., Aracil, C. L. D. A., Clotet, N. C., Fraile, I. P., García, S., Hernández, C. M., et al. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2015.12.010 · Cited by 65
Risk factors for recurrent venous thromboembolism after unprovoked pulmonary embolism: the PADIS-PE randomised trial
Tromeur, C., Sanchez, O., Presles, É., Pernod, G., Bertoletti, L., Jégo, P., Duhamel, E., Provost, K., Parent, F., Robin, P., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.01202-2017 · Cited by 64
Rosuvastatin use improves measures of coagulation in patients with venous thrombosis
Biedermann, J. S., Kruip, M. J. H. A., van der Meer, F. J., Rosendaal, F. R., Leebeek, F. W. G., Cannegieter, S. C., & Lijfering, W. M. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy014 · Cited by 63
A lower risk of recurrent venous thrombosis in women compared with men is explained by sex-specific risk factors at time of first venous thrombosis in thrombophilic families
Lijfering, W. M., Veeger, N. J. G. M., Middeldorp, S., Hamulyák, K., Prins, M. H., Buller, H. R., & van der Meer, J. (2009) · Blood · doi:10.1182/blood-2009-04-215418 · Cited by 61
Assessing the risk of recurrent venous thromboembolism – a practical approach
Keo, H. H., Fahrni, J., Husmann, M. J. W., & Gretener, S. B. (2015) · Vascular Health and Risk Management · doi:10.2147/vhrm.s83718 · Cited by 60
Unprovoked recurrent venous thrombosis: prediction by D‐dimer and clinical risk factors
Baglin, T. P., Palmer, C. R., Luddington, R. J., & Baglin, C. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.02889.x · Cited by 59
Circulating tissue factor positive microparticles in patients with acute recurrent deep venous thrombosis
Ye, R., Ye, C., Huang, Y., Liu, L., & Wang, S. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.10.014 · Cited by 58
Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin
Cueni, L. N., Chen, L., Zhang, H., Marino, D., Huggenberger, R., Alitalo, A. K., Bianchi, R., & Detmar, M. J. (2010) · Blood · doi:10.1182/blood-2010-04-278564 · Cited by 58
Sex Difference in the Prevalence of Deep-Vein Thrombosis in Japanese Patients with Acute Intracerebral Hemorrhage
Kawase, K., Okazaki, S., Toyoda, Ḱ., Toratani, N., Yoshimura, S., Kawano, H., Nagatsuka, K., Matsuo, H., Naritomi, H., & Minematsu, K. (2009) · Cerebrovascular Diseases · doi:10.1159/000202006 · Cited by 58
Pulmonary embolism: Epidemiology and registries
Monréal, M., Mahé, I., Bura-Rivière, A., Prandoni, P., Verhamme, P. B., Brenner, B., Wells, P. S., Micco, P. D., & Bertoletti, L. (2015) · La Presse Médicale · doi:10.1016/j.lpm.2015.10.006 · Cited by 56
Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms
Stein, B. L., RADEMAKER, A. W., Spivak, J. L., & Moliterno, A. R. (2011) · Thrombosis · doi:10.1155/2011/874146 · Cited by 55
Impact of gender on the clinical presentation and diagnosis of deep-vein thrombosis
Riess, H. B., Hach-Wunderle, V., Gerlach, H. E., Carnarius, H., Eberle, S., Rabe, E., Schellong, S., & Bauersachs, R. M. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-10-0705 · Cited by 54
Superficial vein thrombosis and recurrent venous thromboembolism: a pooled analysis of two observational studies
Galanaud, J. ‐., Bosson, J., Genty, C., Presles, É., Cucherat, M., Sevestre, M., Quéré, I., Decousus, H., & Leizorovicz, A. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2012.04704.x · Cited by 53
Differences in clinical presentation of pulmonary embolism in women and men
Robert‐Ebadi, H., Gal, G. L., Carrier, M., Couturaud, F., Perrier, A., Bounameaux, H. M., & Righini, M. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03774.x · Cited by 50
OSA Is a Risk Factor for Recurrent VTE
Alonso‐Fernández, A., Suquia, A. G., de la Peña, M., Casitas, R., Piérola, J., Barceló, A., Soriano, J. B., Fernández‐Capitán, C., Martínez-Cerón, E., Carrera, M., et al. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.07.011 · Cited by 51
Influence of sex on risk of bleeding in anticoagulated patients: a systematic review and meta‐analysis
Lapner, S. T., Cohen, N., & Kearon, C. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12529 · Cited by 47
Predicting recurrence after unprovoked venous thromboembolism: prospective validation of the updated Vienna Prediction Model
Tritschler, T., Méan, M., Limacher, A., Rodondi, N., & Aujesky, D. (2015) · Blood · doi:10.1182/blood-2015-04-641225 · Cited by 46
Sex-specific risk factors for recurrent venous thromboembolism
Olié, V., Zhu, T., Martinez, I., Scarabin, P., & Emmerich, J. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.10.026 · Cited by 44
Differences in clinical presentation of deep vein thrombosis in men and women
ANDREOU, E. R., Koru‐Sengul, T., Linkins, L., Bates, S. M., Ginsberg, J. S., & Kearon, C. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03110.x · Cited by 43
Brain Control of Sexually Dimorphic Liver Function and Disease: The Endocrine Connection
Brie, B., Ramirez, M. C., Winne, C. D., Vicchi, F. L., Villarruel, L. A., Sorianello, E. M., Catalano, P. N., Ornstein, A. M., & Becú‐Villalobos, D. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00652-0 · Cited by 39
Recurrent Venous Thromboembolism: What Is the Risk and How to Prevent It
Palareti, G. (2012) · Scientifica · doi:10.6064/2012/391734 · Cited by 44
Deep vein thrombus formation induced by flow reduction in mice is determined by venous side branches
Brandt, M., Schönfelder, T., Schwenk, M., Becker, C., Jäckel, S., Reinhardt, C., Stark, K., Maßberg, S., Münzel, T. F., von Brühl, M.-L., et al. (2014) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-131680 · Cited by 42
Unprovoked Venous Thromboembolism: Short term or Indefinite Anticoagulation? Balancing Long-Term Risk and Benefit
Rodger, M. A., Carrier, M., Gándara, E., & Gal, G. L. (2010) · Blood Reviews · doi:10.1016/j.blre.2010.06.001 · Cited by 41
Sex-based disparities in venous thromboembolism outcomes: A National Inpatient Sample (NIS)-based analysis
Marshall, A. L., Bartley, A. C., Ashrani, A. A., Pruthi, R. K., Durani, U., Gonsalves, W. I., Kapoor, P., Hashmi, S. K., Siddiqui, M. A., & Go, R. S. (2017) · Vascular Medicine · doi:10.1177/1358863x17693103 · Cited by 41
Sex, age and normal post‐anticoagulation D‐dimer as risk factors for recurrence after idiopathic venous thromboembolism in the Prolong study extension
Cosmi, B., Legnani, C., Tosetto, A., Pengo, V., Ghirarduzzi, A., Testa, S., Prisco, D., Poli, D., Tripodi, A., & Palareti, G. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03955.x · Cited by 40
Impact of sex and traditional cardiovascular risk factors on the risk of recurrent venous thromboembolism: results from the German MAISTHRO Registry
Linnemann, B., Zgouras, D., Schindewolf, M., Schwonberg, J., Jarosch-Preusche, M., & Lindhoff‐Last, E. (2008) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e3282f54558 · Cited by 39
Hematocrit and the Risk of Recurrent Venous Thrombosis: A Prospective Cohort Study
Eischer, L., Tscholl, V., Heinze, G., Traby, L., Kyrle, P. A., & Eichinger, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038705 · Cited by 39
Long-term death and recurrence in patients with acute venous thromboembolism: The MASTER registry
Verso, M., Agnelli, G., Ageno, W., Imberti, D., Moia, M., Palareti, G., Pistelli, R., & Cantone, V. (2012) · Thrombosis Research · doi:10.1016/j.thromres.2012.04.003 · Cited by 39
Thrombotic and hemorrhagic burden in women: Gender-related issues in the response to antithrombotic therapies
Renda, G., Patti, G., Lang, I. M., Siller-Matula, J. M., Hylek, E. M., Ambrosio, G., Haas, S. K., & Caterina, R. D. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.02.004 · Cited by 39
The Prothrombotic Phenotypes in Familial Protein C Deficiency Are Differentiated by Computational Modeling of Thrombin Generation
Brummel‐Ziedins, K. E., Orfeo, T., CALLAS, P. W., Gissel, M., Mann, K. G., & Bovill, E. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044378 · Cited by 38
Long-term risk of venous thrombosis after stopping anticoagulants for a first unprovoked event: A multi-national cohort
Rodger, M. A., Scarvelis, D., Kahn, S. R., Wells, P. S., Anderson, D. A., Chagnon, I., Gal, G. L., Gándara, E., Solymoss, S., Sabri, E., et al. (2016) · Thrombosis Research · doi:10.1016/j.thromres.2016.03.028 · Cited by 36
Recurrent Thrombosis and Survival After a First Venous Thrombosis of the Upper Extremity
Flinterman, L. E., Vlieg, A. V. H., Rosendaal, F. R., & Doggen, C. J. M. (2008) · Circulation · doi:10.1161/circulationaha.107.748699 · Cited by 36
Sex difference in the risk of recurrent venous thrombosis: a detailed analysis in four European cohorts
Roach, R. E. J., Lijfering, W. M., Tait, R. C., Baglin, T. P., Kyrle, P. A., Cannegieter, S. C., & Rosendaal, F. R. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13116 · Cited by 36
Procoagulant activity, but not number, of microparticles increases with age and in individuals after a single venous thromboembolism
Owen, B. A. L., Xue, A., Heit, J. A., & Owen, W. G. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2010.10.018 · Cited by 34
Thrombophilia testing in people with venous thromboembolism: systematic review and cost-effectiveness analysis
Simpson, E. L., Stevenson, M., Rawdin, A., & Papaioannou, D. E. (2009) · Health Technology Assessment · doi:10.3310/hta13020 · Cited by 33
A GENS-based Approach to Cardiovascular Pharmacology: Impact on metabolism, Pharmacokinetics and Pharmacodynamics
Franconi, F., Carru, C., Spoletini, I., Malorni, W., Vella, S., Mercuro, G., Deidda, M., & Rosano, G. M. C. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.117 · Cited by 32
Pathogenesis, Diagnosis, and Treatment of Venous Thromboembolism in Older Adults
Johnson, S. A., Eleazer, G. P., & Rondina, M. T. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14279 · Cited by 32
Risk of recurrent venous thromboembolism among young women after a first event while exposed to combined oral contraception versus not exposed to: A cohort study
Moigne, E. L., Delluc, A., Tromeur, C., Nowak, E., Mottier, D., Lacut, K., & Gal, G. L. (2013) · Thrombosis Research · doi:10.1016/j.thromres.2013.05.028 · Cited by 33
d -dimer Level as a Predictor of Recurrent Stroke in Patients With Embolic Stroke of Undetermined Source
Choi, K., Kim, J., Kim, J., Kang, K. W., Lee, C., Kim, J., Choi, S., Park, M., & Cho, K. (2021) · Stroke · doi:10.1161/strokeaha.120.033217 · Cited by 30
High Plasma D-Dimer is a Marker of Deep Vein Thrombosis in Acute Stroke
Kuwashiro, T., Toyoda, Ḱ., Oyama, N., Kawase, K., Okazaki, S., Nagano, K., Koga, M., Matsuo, H., Naritomi, H., & Minematsu, K. (2010) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2010.06.009 · Cited by 30
Predicting the risk of recurrent venous thromboembolism (VTE)
Streiff, M. B. (2015) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-015-1188-4 · Cited by 30
Men had a Higher Risk of Recurrent Venous Thromboembolism than Women: A Large Population Study
Tagalakis, V., Kondal, D., Ji, Y., Boivin, J., Moride, Y., Ciampi, A., & Kahn, S. R. (2012) · Gender Medicine · doi:10.1016/j.genm.2011.12.002 · Cited by 29
Extended anticoagulation after venous thromboembolism: should it be done?
Fernandes, C. J. C. D. S., Calderaro, D., Piloto, B. M., Hoette, S., Jardim, C., & Souza, R. (2019) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753466619878556 · Cited by 28
Metabolic Syndrome Increases Risk of Venous Thromboembolism Recurrence after Acute Pulmonary Embolism
Stewart, L. K., & Kline, J. A. (2020) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201907-518oc · Cited by 28
Indefinite anticoagulation after a first episode of unprovoked venous thromboembolism: yes
Kearon, C. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02761.x · Cited by 28
Assessing recurrence risk following acute venous thromboembolism
Poli, D., & Palareti, G. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328363ed7c · Cited by 27
Duration of anticoagulant therapy for venous thromboembolism: balancing benefits and harms on the long term
de Jong, P. G., Coppens, M., & Middeldorp, S. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09196.x · Cited by 27
Predictors and Outcomes of Recurrent Venous Thromboembolism in Elderly Patients
Lauber, S., Limacher, A., Tritschler, T., Stalder, O., Méan, M., Righini, M., Aschwanden, M., Beer, J. H., Frauchiger, B., Osterwalder, J., et al. (2018) · The American Journal of Medicine · doi:10.1016/j.amjmed.2017.12.015 · Cited by 27

Authors: McRae, S., Tran, H., Schulman, S., Ginsberg, J., & Kearon, C.
Affiliations: McMaster University Medical Centre (CA)
Hamilton General Hospital (CA)
McMaster University (CA)
Corresponding author: McRae, Simon
ORCID: McRae, Simon
Tran, Huyen
Schulman, Sam
Venue: The Lancet
Publisher: Elsevier BV
Published: 2006-07
Volume: 368
Issue: 9533
Pages: 371-378
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(06)69110-1
OpenAlex: W2129839379
Cited by: 289
References: 37
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 13 · 2021: 8 · 2020: 13 · 2019: 12 · 2018: 11 · 2017: 8 · 2016: 23 · 2015: 22 · 2014: 18 · 2013: 21 · 2012: 21
FWCI: 4.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Clinical Neurology › Cerebral Venous Sinus Thrombosis
Keywords: sex differences, anticoagulation, anticoagulation discontinuation, men versus women, anticoagulation duration, estrogen therapy, pregnancy, venous thromboembolism risk
MeSH terms: Aged, Anticoagulants, Female, Humans, Hypertension, Pulmonary, Male, Middle Aged, Recurrence, Risk Factors, Randomized Controlled Trials as Topic, Sex Distribution, Venous Thrombosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of patient's sex on risk of recurrent venous thromboembolism: a meta-analysis.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks