Cited by 1,277Venous Thromboembolism Diagnosis and ManagementBlood Coagulation and Thrombosis MechanismsCerebral Venous Sinus Thrombosis

Epidemiology of venous thromboembolism

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Heit, John A.·2015·Nature Reviews Cardiology

Abstract

Thrombosis can affect any venous circulation. Venous thromboembolism (VTE) includes deep-vein thrombosis of the leg or pelvis, and its complication, pulmonary embolism. VTE is a fairly common disease, particularly in older age, and is associated with reduced survival, substantial health-care costs, and a high rate of recurrence. VTE is a complex (multifactorial) disease, involving interactions between acquired or inherited predispositions to thrombosis and various risk factors. Major risk factors for incident VTE include hospitalization for surgery or acute illness, active cancer, neurological disease with leg paresis, nursing-home confinement, trauma or fracture, superficial vein thrombosis, and-in women-pregnancy and puerperium, oral contraception, and hormone therapy. Although independent risk factors for incident VTE and predictors of VTE recurrence have been identified, and effective primary and secondary prophylaxis is available, the occurrence of VTE seems to be fairly constant, or even increasing.

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Authors
Heit, J. A.
Affiliations
Mayo Clinic (US)
Corresponding author
Heit, John A.
Venue
Nature Reviews Cardiology
Published
2015-06-16
Volume
12
Issue
8
Pages
464-474
ISSN
  • 1759-5002 (ISSN-L)
  • 1759-5010
OpenAlex
W1597337165
Cited by
1,277
References
281
Citations by year
2026: 113 · 2025: 114 · 2024: 153 · 2023: 157 · 2022: 125 · 2021: 164 · 2020: 112 · 2019: 105 · 2018: 89 · 2017: 79 · 2016: 37 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 4
FWCI
18.23
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Mayo Foundation for Medical Education and Research
  • National Heart, Lung, and Blood Institute (R01HL066216)
Topics
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Neurology › Cerebral Venous Sinus Thrombosis
Keywords
venous thromboembolism, deep vein thrombosis, pulmonary embolism, thrombosis risk factors, cancer-associated thrombosis, pregnancy and puerperium, oral contraception, hormone therapy, hospitalization, recurrent thrombosis, thromboprophylaxis, health care costs
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Costs and Cost Analysis, Epidemiologic Methods, Female, Humans, Infant, Infant, Newborn, Leg, Male, Middle Aged, Pelvis, Pulmonary Embolism, Recurrence, Age Distribution, Venous Thromboembolism, Secondary Prevention, Young Adult

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