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The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study

Open access
Whitney, Cynthia G, Pilishvili, Tamar, Farley, Monica M, Schaffner, William, Craig, Allen S, Lynfield, Ruth, Nyquist, Ann-Christine, Gershman, Kenneth A, Vazquez, Marietta, Bennett, Nancy M, Reingold, Arthur, Thomas, Ann, Glode, Mary P, Zell, Elizabeth R, Jorgensen, James H, Beall, Bernard, Schuchat, Anne·2006·The Lancet
DOI 10.1016/s0140-6736(06)69637-2
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Abstract

BACKGROUND When seven-valent pneumococcal conjugate vaccine was introduced in the USA, many children were vaccinated on schedules that differed from those tested in clinical trials. Our aim was to assess the effectiveness of the vaccine against various pneumococcal serotypes, and to measure the effectiveness of the recommended dose schedule and of catch-up and incomplete schedules. METHODS Invasive disease, defined as isolation of pneumococcus from a sterile site, was identified in children aged 3-59 months through the US Centers for Disease Control and Prevention's Active Bacterial Core surveillance. We tested isolates for serotype and antimicrobial susceptibility. Three controls, matched for age and zip code were selected for each case. We calculated the matched odds ratio for vaccination using conditional logistic regression, controlling for underlying conditions. Vaccine effectiveness was calculated as one minus the adjusted matched odds ratio times 100%. FINDINGS We enrolled 782 cases and 2512 controls. Effectiveness of one or more doses against vaccine serotypes was 96% (95% CI 93-98) in healthy children and 81% (57-92) in those with coexisting disorders. It was 76% (63-85) against infections that were not susceptible to penicillin. Vaccination prevented disease caused by all seven vaccine serotypes, and by vaccine-related serotype 6A. Several schedules were more protective than no vaccination; three infant doses with a booster were more protective against vaccine-type disease than were three infant doses alone (p=0.0323). INTERPRETATION The seven-valent pneumococcal conjugate vaccine prevents invasive disease in both healthy and chronically ill children. The vaccine is effective when used with various non-standard schedules.

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Metadata

Authors
Whitney, C. G., Pilishvili, T., Farley, M. M., Schaffner, W., Craig, A. S., Lynfield, R., Nyquist, A.-C., Gershman, K. A., Vazquez, M., Bennett, N. M., Reingold, A., Thomas, A., Glode, M. P., Zell, E. R., Jorgensen, J. H., Beall, B., & Schuchat, A.
Venue
The Lancet
Publisher
Elsevier BV
Published
2006-10
Volume
368
Issue
9546
Pages
1495-1502
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(06)69637-2
OpenAlex
W3025897641
Cited by
623
References
29
FWCI
34.31
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study. https://app.cochat.ai/papers/10.1016/s0140-6736(06)69637-2
The paper
Whitney, C. G., Pilishvili, T., Farley, M. M., Schaffner, W., Craig, A. S., Lynfield, R., Nyquist, A.-C., Gershman, K. A., Vazquez, M., Bennett, N. M., Reingold, A., Thomas, A., Glode, M. P., Zell, E. R., Jorgensen, J. H., Beall, B., & Schuchat, A. (2006). Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study. The Lancet. https://doi.org/10.1016/s0140-6736(06)69637-2

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.