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Cited by 665Respiratory and Cough-Related ResearchPathogenesis and Treatment of HiccupsAsthma and respiratory diseases

The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.

Prevalence, pathogenesis, and causes of chronic cough

Chung, Kian Fan, Pavord, Ian D·2008·The Lancet
DOI 10.1016/s0140-6736(08)60595-4
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Abstract

Cough is a reflex action of the respiratory tract that is used to clear the upper airways. Chronic cough lasting for more than 8 weeks is common in the community. The causes include cigarette smoking, exposure to cigarette smoke, and exposure to environmental pollution, especially particulates. Diseases causing chronic cough include asthma, eosinophilic bronchitis, gastro-oesophageal reflux disease, postnasal drip syndrome or rhinosinusitis, chronic obstructive pulmonary disease, pulmonary fibrosis, and bronchiectasis. Doctors should always work towards a clear diagnosis, considering common and rare illnesses. In some patients, no cause is identified, leading to the diagnosis of idiopathic cough. Chronic cough is often associated with an increased response to tussive agents such as capsaicin. Plastic changes in intrinsic and synaptic excitability in the brainstem, spine, or airway nerves can enhance the cough reflex, and can persist in the absence of the initiating cough event. Structural and inflammatory airway mucosal changes in non-asthmatic chronic cough could represent the cause or the traumatic response to repetitive coughing. Effective control of cough requires not only controlling the disease causing the cough but also desensitisation of cough pathways.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(08)60595-4

Cites

155 of 155 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • An inability to efficiently cough, for instance due to fatigue or breathlessness, can cause increased susceptibility to infection due to secretion retention.

    “On the other hand, an inability to efficiently cough, for instance, due to fatigue or breathlessness, can cause increased susceptibility to infection due to secretion retention. 66”

    From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [66]

Citations

Cites

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Research works printed but not linked: 3

  1. Kohno, 2006, The Japanese Respiratory Society guidelines for management of cough, Respirology, 11, S135
  2. Mund, 2005, Noneosinophilic CD4 lymphocytic airway inflammation in menopausal women with chronic dry cough, Chest, 127, 1714, 10.1378/chest.127.5.1714 · DOI
  3. Niimi, 2005, Nature of airway inflammation and remodeling in chronic cough, J Allergy Clin Immunol, 116, 565, 10.1016/j.jaci.2005.07.010 · DOI

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Metadata

Authors
Chung, K. F., & Pavord, I. D.
Affiliations
  • Royal Brompton Hospital (GB)
  • Glenfield Hospital (GB)
Corresponding author
Chung, Kian Fan
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
2008-04
Volume
371
Issue
9621
Pages
1364-1374
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(08)60595-4
OpenAlex
W2088140593
Cited by
665
References
155
Citations by year
2026: 23 · 2025: 37 · 2024: 51 · 2023: 50 · 2022: 45 · 2021: 53 · 2020: 41 · 2019: 42 · 2018: 29 · 2017: 38 · 2016: 33 · 2015: 47 · 2014: 31 · 2013: 31 · 2012: 25
FWCI
4.70
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
  • Health Sciences › Medicine › Physiology (medical) › Pathogenesis and Treatment of Hiccups
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords
chronic cough, asthma, eosinophilic bronchitis, gastroesophageal reflux disease, postnasal drip syndrome, sinusitis, chronic obstructive pulmonary disease, pulmonary fibrosis, bronchiectasis, cigarette smoke exposure, capsaicin challenge, cough reflex
MeSH terms
Adult, Air Pollutants, Bacterial Infections, Child, Chronic Disease, Cough, Humans, Reflex, Respiratory Sounds, Smoking, Prevalence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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