Aortic stenosis
Abstract
In developed countries, aortic stenosis is the most prevalent of all valvular heart diseases. A manifestation of ageing, the disorder is becoming more frequent as the average age of the population increases. Symptomatic severe disease is universally fatal if left untreated yet is consistent with a typical lifespan when mechanical relief of the stenosis is provided in a timely fashion. Management of mild disease, severe asymptomatic disease, and far advanced disease, and the effect of new percutaneous treatments, provide both controversy and exciting promise to care of patients with aortic stenosis. We discuss these issues in this Review.
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Aortic stenosis is the most prevalent valvular heart disease in developed countries, often remains asymptomatic for years, but prognosis worsens sharply once symptoms develop.
“Aortic stenosis, the most prevalent valvular heart disease in developed countries, often remains asymptomatic for years, but prognosis worsens sharply once symptoms develop.5”
From AI-ECG for Echocardiography Triage in Structural Heart Disease: Evidence, Implementation, and Future Directions (2026) · cites this paper as [5]
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Tang, Q., Deng, K., Cui, Y., Liu, H., & Qian, B. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s610298
- Authors
- Carabello, B. A., & Paulus, W. J.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Carabello, Blase A
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 373
- Issue
- 9667
- Pages
- 956-966
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4230220778
- Cited by
- 818
- References
- 7
- Citations by year
- 2026: 40 · 2025: 53 · 2024: 57 · 2023: 62 · 2022: 60 · 2021: 64 · 2020: 57 · 2019: 48 · 2018: 45 · 2017: 46 · 2016: 51 · 2015: 50 · 2014: 36 · 2013: 40 · 2012: 52
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Keywords
- aortic stenosis, valvular heart disease, aging, asymptomatic disease, mild aortic stenosis, mechanical heart valve replacement, disease management
- MeSH terms
- Aging, Aortic Valve Stenosis, Calcinosis, Cardiac Output, Female, Cardiac Catheterization, Heart Valve Prosthesis, Humans, Male, Physical Examination, Syncope, Biomarkers, Angioplasty, Balloon, Coronary, Survival Analysis, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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