Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure?

Kupari, Markku; Turto, Heikki; Lommi, Jyri

doi:10.1093/eurheartj/ehi290

Cited by 233Cardiac Valve Diseases and TreatmentsCardiovascular Function and Risk FactorsAortic Disease and Treatment Approaches

Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure?

Kupari, Markku, Turto, Heikki, Lommi, Jyri·2005·European Heart Journal

DOI 10.1093/eurheartj/ehi290

Open this paper in CoChat — free account

Abstract

AIMS: In aortic stenosis (AS), left ventricular (LV) hypertrophy is considered a compensatory response helping maintain systolic function. Recent research in experimental AS suggests, however, that LV hypertrophy is not necessary to sustain LV contractions but may in fact be maladaptive. The present work aimed to clarify the role of LV hypertrophy in AS-related heart failure (HF) in man. METHODS AND RESULTS: We studied 137 adult patients with isolated AS undergoing pre-operative echocardiography and cardiac catheterization. HF was diagnosed by the European criteria and LV hypertrophy by sex-specific limits of echocardiographic LV mass. The higher the LV mass was, the poorer was the LV ejection fraction (beta=-0.26, P< 0.001, linear regression) and the greater the likelihood of HF independent of the severity of AS (P< 0.001, logistic regression). In the subgroup of critical AS (valve area <0.4 cm(2)/m(2), n=85), patients with absent LV hypertrophy (n=19) had better preserved ejection fraction (mean+/-SE, 64+/-3 vs. 57+/-2%, P=0.045) and less HF (16 vs. 48%, P=0.025) than patients with LV hypertrophy (n=66). CONCLUSION: In isolated AS, increased LV mass predicts the presence of systolic dysfunction and HF independent of the severity of valvular obstruction. LV hypertrophy may be maladaptive rather than beneficial in AS in man.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehi290

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The LV response to chronic pressure overload from aortic stenosis is characterized by hypertrophic remodelling with myocyte hypertrophy and fibrosis, and by diastolic and systolic dysfunction.
“The LV response to chronic pressure overload from AS is characterized by hypertrophic remodelling (myocyte hypertrophy and fibrosis) and diastolic and systolic dysfunction.”
From Calcific aortic stenosis (2016) · cites this paper as [258]
The Introduction (page unavailable) describes increased LV wall thickness and mass in aortic stenosis, notes possible impairment of diastolic function, and reports an association between increased LV mass and systolic dysfunction. It does not describe fibrosis or establish that diastolic and systolic dysfunction characterize every LV response to aortic stenosis; it notes preserved systolic function in some patients with critical stenosis. (LLM, conf=0.86)
Experimental — accuracy not yet measured
This LV response considerably influences the morbidity and mortality of aortic stenosis.
“In many ways, this LV response considerably influences the morbidity and mortality of the disease199;257–260.”
From Calcific aortic stenosis (2016) · cites this paper as [258]
In “Predictors of HF and ejection fraction” (page unavailable), higher LV mass is independently associated with heart failure and lower ejection fraction in patients with aortic stenosis, supporting the morbidity aspect. The paper does not establish that the LV response influences mortality; its mortality discussion in “Methodological considerations” (page unavailable) does not test that relationship. The claim also states an influence more strongly than the study’s observational associations establish. (LLM, conf=0.85)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O’Gara, P. T., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176857 · Cited by 8,479 · see citing works
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226 · see citing works
Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart study
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699 · see citing works
Wall stress and patterns of hypertrophy in the human left ventricle.
Grossman, W., Jones, D., & McLaurin, L. P. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108079 · Cited by 2,403 · see citing works
Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis
Rosenhek, R., Binder, T. M., Porenta, G., Lang, I. M., Christ, G., SCHEMPER, M., Maurer, G., & Baumgartner, H. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008313430903 · Cited by 1,332 · see citing works
Prevalence of aortic valve abnormalities in the elderly: An echocardiographic study of a random population sample
Lindroos, M., Kupari, M. M., Heikkilä, J., & Tilvis, R. S. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90249-z · Cited by 1,148 · see citing works
Self-citation
Prospective Study of Asymptomatic Valvular Aortic Stenosis: Clinical, Echocardiographic, and Exercise Predictors of Outcome
Otto, C. M., Burwash, I. G., Legget, M. E., Munt, B. I., Fujioka, M., Healy, N. L., Kraft, C. D., Miyake-Hull, C. Y., & Schwaegler, R. G. (1997) · Circulation · doi:10.1161/01.cir.95.9.2262 · Cited by 1,146 · see citing works
Guidelines for the Management of Patients With Valvular Heart Disease
Bonow, R. O., Carabello, B. A., de Leon, A. C., Edmunds, L. H., Fedderly, B. J., Freed, M. D., Gaasch, W. H., McKay, C. R., Nishimura, R. A., O’Gara, P. T., et al. (1998) · Circulation · doi:10.1161/01.cir.98.18.1949 · Cited by 1,022 · see citing works
Hypertrophy of the Heart
Frey, N., Katus, H. A., Olson, E. N., & Hill, J. A. (2004) · Circulation · doi:10.1161/01.cir.0000120390.68287.bb · Cited by 845 · see citing works
Standardization of M-mode echocardiographic left ventricular anatomic measurements
Devereux, R. B., Lutas, E. M., Casale, P. N., Kligfield, P., Eisenberg, R. R., Hammond, I. W., Miller, D. H., Reis, G. J., Alderman, M. H., & Laragh, J. H. (1984) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(84)80141-2 · Cited by 742 · see citing works
Sex-associated differences in left ventricular function in aortic stenosis of the elderly.
Carroll, J. D., Carroll, E. P., Feldman, T., Ward, D. M., Lang, R. M., McGaughey, D., & Karp, R. B. (1992) · Circulation · doi:10.1161/01.cir.86.4.1099 · Cited by 488 · see citing works
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, C. L., McKinsey, T. A., Frey, N., Kutschke, W. J., McAnally, J., Shelton, J. M., Richardson, J. A., Hill, J. A., & Olson, E. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231619298 · Cited by 477 · see citing works
Geometric changes allow normal ejection fraction despite depressed myocardial shortening in hypertensive left ventricular hypertrophy
Aurigemma, G. P., Silver, K. H., Priest, M. A., & Gaasch, W. H. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00153-q · Cited by 399 · see citing works
The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis
Pellikka, P. A., Nishimura, R. A., Bailey, K. R., & Tajik, A. J. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90234-g · Cited by 391 · see citing works
Genetic Alterations That Inhibit In Vivo Pressure-Overload Hypertrophy Prevent Cardiac Dysfunction Despite Increased Wall Stress
Esposito, G., Rapacciuolo, A., Prasad, S. V. N., Takaoka, H., THOMAS, S. A., Koch, W. J., & Rockman, H. A. (2002) · Circulation · doi:10.1161/hc0102.101365 · Cited by 371 · see citing works
Determinants of ventricular function in pressure-overload hypertrophy in man.
Gunther, S., & Grossman, W. (1979) · Circulation · doi:10.1161/01.cir.59.4.679 · Cited by 349 · see citing works
Association of Angiotensin-Converting Enzyme With Low-Density Lipoprotein in Aortic Valvular Lesions and in Human Plasma
O’Brien, K. D., Shavelle, D. M., Caulfield, M. T., McDonald, T. O., Olin, K. L., Otto, C. M., & Probstfield, J. L. (2002) · Circulation · doi:10.1161/01.cir.0000035655.45453.d2 · Cited by 320 · see citing works
Serial Echocardiographic-Doppler Assessment of Left Ventricular Geometry and Function in Rats With Pressure-Overload Hypertrophy
Litwin, S. E., Katz, S. E., Weinberg, E. O., Lorell, B. H., Aurigemma, G. P., & Douglas, P. S. (1995) · Circulation · doi:10.1161/01.cir.91.10.2642 · Cited by 310 · see citing works
Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
Hill, J. A., Karimi, M., Kutschke, W., Davisson, R. L., Zimmerman, K., Wang, Z., Kerber, R. E., & Weiss, R. M. (2000) · Circulation · doi:10.1161/01.cir.101.24.2863 · Cited by 309 · see citing works
Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis.
Weinberg, E. O., Schöen, F. J., George, D., Kagaya, Y., Douglas, P. S., Litwin, S. E., Schunkert, H., Benedict, C. R., & Lorell, B. H. (1994) · Circulation · doi:10.1161/01.cir.90.3.1410 · Cited by 241 · see citing works
Induction of local angiotensin II-producing systems in stenotic aortic valves
Helske, S., Lindstedt, K. A., Laine, M., Mäyränpää, M. I., Werkkala, K., Lommi, J., Turto, H., Kupari, M. M., & Kovanen, P. T. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.07.054 · Cited by 221 · see citing works
Self-citation
Progression of aortic stenosis in 394 patients: Relation to changes in myocardial and mitral valve dysfunction
Brener, S. J., Duffy, C. I., Thomas, J. D., & Stewart, W. J. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)00406-g · Cited by 174 · see citing works
Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy
Lips, D. J. (2003) · European Heart Journal · doi:10.1016/s0195-668x(02)00829-1 · Cited by 172 · see citing works
Safety and efficacy of angiotensin-converting enzyme inhibitors in symptomatic severe aortic stenosis: symptomatic cardiac obstruction–pilot study of enalapril in aortic stenosis (SCOPE-AS)
Chockalingam, A., Venkatesan, S., Subramaniam, T., Jagannathan, V., Elangovan, S., Alagesan, R., Gnanavelu, G., Dorairajan, S., Krishna, B. P., & Chockalingam, V. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.10.017 · Cited by 156 · see citing works
Blockade of the Renin-Angiotensin System in Cardiac Pressure-Overload Hypertrophy in Rats
Bruckschlegel, G., Holmer, S. R., Jandeleit-Dahm, K. A. M., Grimm, D. G., Muders, F., Kromer, E. P., Riegger, G. A. J., & Schunkert, H. (1995) · Hypertension · doi:10.1161/01.hyp.25.2.250 · Cited by 155 · see citing works
Symptomatic Aortic Stenosis
Antonini‐Canterin, F., Huang, G., Cervesato, E., Faggiano, P. M., Pavan, D., Piazza, R., & Nicolosi, G. L. (2003) · Hypertension · doi:10.1161/01.hyp.0000070029.30058.59 · Cited by 148 · see citing works
Gender differences in left ventricle geometry and function in patients undergoing balloon dilatation of the aortic valve for isolated aortic stenosis. NHLBI Balloon Valvuloplasty Registry.
Douglas, P. S., Otto, C. M., Mickel, M. C., Labovitz, A. J., Reid, C. L., & Davis, K. B. (1995) · Heart · doi:10.1136/hrt.73.6.548 · Cited by 138 · see citing works
Correlates of left ventricular mass in a population sample aged 36 to 37 years. Focus on lifestyle and salt intake.
Kupari, M. M., Koskinen, P., & Virolainen, J. (1994) · Circulation · doi:10.1161/01.cir.89.3.1041 · Cited by 123 · see citing works
Self-citation
Targeted Inhibition of Calcineurin in Pressure-overload Cardiac Hypertrophy
Hill, J. A., Rothermel, B. A., Yoo, K., Cabuay, B. M., Demetroulis, E., Weiss, R. M., Kutschke, W. J., Bassel‐Duby, R., & Williams, R. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110722200 · Cited by 121 · see citing works
Hemodynamic Effects of the Angiotensin-Converting Enzyme Inhibitor, Ramipril, in Patients with Mild to Moderate Aortic Stenosis and Preserved Left Ventricular Function
O’Brien, K. D., Zhao, X.-Q., Shavelle, D. M., Caulfield, M. T., Letterer, R. A., Kapadia, S. R., Probstfield, J. L., & Otto, C. M. (2004) · Journal of Investigative Medicine · doi:10.1136/jim-52-03-33 · Cited by 93 · see citing works
Chronic N G -Nitro- l -Arginine Methyl Ester–Induced Hypertension
Bartúnek, J., Weinberg, E. O., Tajima, M., Rohrbach, S., Katz, S. E., Douglas, P. S., & Lorell, B. H. (2000) · Circulation · doi:10.1161/01.cir.101.4.423 · Cited by 89 · see citing works
Angiotensin-converting enzyme gene polymorphism influences degree of left ventricular hypertrophy and its regression in patients undergoing operation for aortic stenosis
Dellgren, G., Eriksson, M. J., Blange, I., Brodin, L., Rådegran, K., & Sylvén, C. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00464-6 · Cited by 62 · see citing works
Severe aortic stenosis without left ventricular hypertrophy: prevalence, predictors, and short-term follow up after aortic valve replacement.
Seiler, C. A., & Jenni, R. (1996) · Heart · doi:10.1136/hrt.76.3.250 · Cited by 51 · see citing works
ACE inhibition in aortic stenosis: dangerous medicine or golden opportunity?
Routledge, H., & Townend, J. (2001) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001260 · Cited by 43 · see citing works
Echocardiographic prediction of clinical outcome in medically treated patients with aortic stenosis
Rossi, A., Tomaino, M., Golia, G., Anselmi, M., Fucă, G., & Zardini, P. (2000) · American Heart Journal · doi:10.1067/mhj.2000.111106 · Cited by 36 · see citing works
Determinants of left ventricular hypertrophy in patients with aortic stenosis
Salcedo, E. E., Korzick, D. H., Currie, P. J., Stewart, W. J., Lever, H. M., & Goormastic, M. (1989) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.56.6.590 · Cited by 33 · see citing works
Lack of association among five genetic polymorphisms of the renin-angiotensin system and cardiac hypertrophy in patients with aortic stenosis
Ortlepp, J. R., Breithardt, O. A., Öhme, F., Hanrath, P., & Hoffmann, R. (2001) · American Heart Journal · doi:10.1067/mhj.2001.113394 · Cited by 29 · see citing works
Heart failure development in rats with ascending aortic constriction and angiotensin‐converting enzyme inhibition
Turčáni, M., & Rupp, H. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703467 · Cited by 21 · see citing works
GENETIC VARIANTS OF PROTEINS FROM THE RENIN ANGIOTENSIN SYSTEM ARE ASSOCIATED WITH PRESSURE LOAD CARDIAC HYPERTROPHY
Wong, K., SUMMERS, K. M., Burstow, D. J., & West, M. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb02788.x · Cited by 16 · see citing works
Diagnosing heart failure in aortic valve stenosis
Kupari, M. M., Turto, H., & Lommi, J. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01404.x · Cited by 9 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 1

The Task Force on Heart Failure of the European Society of Cardiology. Guidelines for the diagnosis of heart failure. Eur Heart J1995;16:741–751.

Sorted by citations

Calcific aortic stenosis
Lindman, B. R., Clavel, M.-A., Mathieu, P., Iung, B., Lancellotti, P., Otto, C. M., & Pibarot, P. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.6 · Cited by 982 · see citing works
Controversies in ventricular remodelling
Opie, L. H., Commerford, P., Gersh, B. J., & Pfeffer, M. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68074-4 · Cited by 856 · see citing works
Aortic stenosis
Carabello, B. A., & Paulus, W. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60211-7 · Cited by 818 · see citing works
Calcific Aortic Stenosis
Dweck, M. R., Boon, N. A., & Newby, D. E. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.093 · Cited by 692 · see citing works
Noninvasive Detection of Fibrosis Applying Contrast-Enhanced Cardiac Magnetic Resonance in Different Forms of Left Ventricular Hypertrophy
Rudolph, A., Abdel‐Aty, H., Bohl, S., Boyé, P., Zagrosek, A., Dietz, R., & Schulz‐Menger, J. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.064 · Cited by 384 · see citing works
Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy
Abel, E. D., & Doenst, T. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr015 · Cited by 263 · see citing works
Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload
Doenst, T., Pytel, G., Schrepper, A., Amorim, P., Färber, G., Shingu, Y., Mohr, F. W., & Schwarzer, M. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp414 · Cited by 246 · see citing works
Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance
Dweck, M. R., Joshi, S., Murigu, T., Gulati, A., Alpendurada, F., Jabbour, A., Maceira, A. M., Roussin, I., Northridge, D. B., Kilner, P. J., et al. (2012) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-14-50 · Cited by 232 · see citing works
Current Management of Calcific Aortic Stenosis
Lindman, B. R., Bonow, R. O., & Otto, C. M. (2013) · Circulation Research · doi:10.1161/circresaha.111.300084 · Cited by 175 · see citing works
Introduction to Aortic Stenosis
Carabello, B. A. (2013) · Circulation Research · doi:10.1161/circresaha.113.300156 · Cited by 159 · see citing works
The Myocardial Oxygen Supply:Demand Index Revisited
Hoffman, J. I. E., & Buckberg, G. D. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000285 · Cited by 160 · see citing works
Prognostic value of myocardial fibrosis in patients with severe aortic valve stenosis
Milano, A. D., Faggian, G. G., Dodonov, M., Golia, G., Tomezzoli, A., Bortolotti, U., & Mazzucco, A. (2012) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2011.11.024 · Cited by 134 · see citing works
Early Cardiac Remodeling Promotes Tumor Growth and Metastasis
Avraham, S., Abu-Sharki, S., Shofti, R., Haas, T., Korin, B., Kalfon, R., Friedman, T., Shiran, A., Saliba, W., Shaked, Y., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.046471 · Cited by 135 · see citing works
Aortic valve stenosis: an active atheroinflammatory process
Helske, S., Kupari, M. M., Lindstedt, K. A., & Kovanen, P. T. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282a66099 · Cited by 132 · see citing works
Self-citation
Diagnostic and prognostic value of cardiovascular magnetic resonance in non-ischaemic cardiomyopathies
Parsai, C., O’Hanlon, R., Prasad, S., & Mohiaddin, R. H. (2012) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-14-54 · Cited by 133 · see citing works
Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves
Helske, S., Syväranta, S., Kupari, M., Lappalainen, J., Laine, M., Lommi, J., Turto, H., Mäyränpää, M., Werkkala, K., Kovanen, P. T., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi706 · Cited by 129 · see citing works
Self-citation
Maladaptive Remodeling Is Associated With Impaired Survival in Women But Not in Men After Aortic Valve Replacement
Petrov, G., Dworatzek, E., Schulze, T. M., Dandel, M., Kararigas, G., Mahmoodzadeh, S., Knosalla, C., Hetzer, R., & Regitz‐Zagrosek, V. (2014) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2014.06.017 · Cited by 111 · see citing works
Management of Asymptomatic Severe Aortic Stenosis
Lindman, B. R., Dweck, M. R., Lancellotti, P., Généreux, P., Piérard, L., O’Gara, P. T., & Bonow, R. O. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2019.01.036 · Cited by 108 · see citing works
RV pressure overload: from hypertrophy to failure
van der Bruggen, C. E. E., Tedford, R. J., Handoko, M. L., van der Velden, J., & de Man, F. S. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx145 · Cited by 103 · see citing works
Left Ventricular Hypertrophy in Valvular Aortic Stenosis: Mechanisms and Clinical Implications
Rader, F., Sachdev, E., Arsanjani, R., & Siegel, R. J. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.10.054 · Cited by 99 · see citing works
A clinical risk score of myocardial fibrosis predicts adverse outcomes in aortic stenosis
Chin, C., Messika–Zeitoun, D., Shah, A. S. V., Lefèvre, G., Bailleul, S., Yeung, E., Koo, M., Mirsadraee, S., Mathieu, T., Semple, S. I. K., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv525 · Cited by 98 · see citing works
Determinants and Functional Significance of Myocardial Perfusion Reserve in Severe Aortic Stenosis
Steadman, C. D., Jerosch‐Herold, M., Grundy, B., Rafelt, S. E., Ng, L. L., Squire, I. B., Samani, N. J., & McCann, G. P. (2012) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2011.09.022 · Cited by 97 · see citing works
Mechanisms of Cardiac Contraction and Relaxation
Opie, L. H., & Hasenfuss, G. P. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00024-x · Cited by 97 · see citing works
Symptom Onset in Aortic Stenosis
Singh, A., Chan, D. C. S., Greenwood, J. P., Dawson, D. K., Sonecki, P., Hogrefe, K., Kelly, D. J., Dhakshinamurthy, V. A., Lang, C. C., Khoo, J. P., et al. (2017) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2017.09.019 · Cited by 96 · see citing works
Adverse Left Ventricular Remodeling in Community-Dwelling Older Adults Predicts Incident Heart Failure and Mortality
Zile, M. R., Gaasch, W. H., Patel, K., Aban, I., & Ahmed, A. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.03.016 · Cited by 87 · see citing works
Asymptomatic Aortic Stenosis in the Elderly
Manning, W. J. (2013) · JAMA · doi:10.1001/jama.2013.279194 · Cited by 77 · see citing works
Left Ventricular Diastolic Function Is Associated With Symptom Status in Severe Aortic Valve Stenosis
Dahl, J. S., Christensen, N. L., Videbæk, L. M., Poulsen, M. K., Carter‐Storch, R., Hey, T. M., Pellikka, P. A., Steffensen, F. H., & Møller, J. E. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000636 · Cited by 76 · see citing works
Left Ventricular Remodelling in Aortic Stenosis
Rassi, A. N., Pîbarot, P., & Elmariah, S. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.04.026 · Cited by 75 · see citing works
The Adverse Impact of Diabetes Mellitus on Left Ventricular Remodeling and Function in Patients With Severe Aortic Stenosis
Lindman, B. R., Arnold, S. V., Madrazo, J. A., Zajarias, A., Johnson, S. N., Pérez, J. E., & Mann, D. L. (2011) · Circulation: Heart Failure · doi:10.1161/circheartfailure.110.960039 · Cited by 68 · see citing works
Aortic Valve Replacement Should Be Operated on Before Symptom Onset
Carabello, B. A. (2012) · Circulation · doi:10.1161/circulationaha.111.079350 · Cited by 67 · see citing works
Early Diastolic Strain Rate in Relation to Systolic and Diastolic Function and Prognosis in Aortic Stenosis
Dahl, J. S., Barros‐Gomes, S., Videbæk, L. M., Poulsen, M. K., Issa, I. F., Carter‐Storch, R., Christensen, N. L., Kumme, A., Pellikka, P. A., & Møller, J. E. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2015.06.029 · Cited by 64 · see citing works
Overexpression of angiotensinogen in the myocardium induces downregulation of the fatty acid oxidation pathway
Pellieux, C., Aasum, E., Larsen, T. S., Montessuit, C., Papageorgiou, I., Pedrazzini, T., & Lerch, R. A. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.06.004 · Cited by 61 · see citing works
Aortic Valve Area, Stroke Volume, Left Ventricular Hypertrophy, Remodeling, and Fibrosis in Aortic Stenosis Assessed by Cardiac Magnetic Resonance Imaging
Barone‐Rochette, G., Piérard, S., Seldrum, S., de Meester, C., Melchior, J., Maes, F., Pouleur, A., Vancraeynest, D., Pasquet, A., Vanoverschelde, J., et al. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000515 · Cited by 61 · see citing works
Towards a Re-Definition of ‘Cardiac Hypertrophy’ Through a Rational Characterization of Left Ventricular Phenotypes: A Position Paper of the Working Group ‘Myocardial Function’ of the ESC
Knöll, R., Iaccarino, G., Tarone, G., Hilfiker‐Kleiner, D., Bauersachs, J. K., Leite-Moreira, A. F., Sugden, P. H., & Balligand, J. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr071 · Cited by 59 · see citing works
Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves
Helske, S., Miettinen, T. A., Gylling, H., Mäyränpää, M. I., Lommi, J., Turto, H., Werkkala, K., Kupari, M. M., & Kovanen, P. T. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800058-jlr200 · Cited by 58 · see citing works
Self-citation
Circulating Levels of miR‐133a Predict the Regression Potential of Left Ventricular Hypertrophy After Valve Replacement Surgery in Patients With Aortic Stenosis
García, R., Villar, A. V., Cobo, M., Llano, M., Martín‐Durán, R., Hurlé, M. A., & Nistal, J. F. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000211 · Cited by 53 · see citing works
Impact of the left ventricular mass index on the outcomes of severe aortic stenosis
Minamino‐Muta, E., Kato, T., Morimoto, T., Taniguchi, T., Inoko, M., Haruna, T., Izumi, T., Miyamoto, S., Nakane, E., Sasaki, K., et al. (2017) · Heart · doi:10.1136/heartjnl-2016-311022 · Cited by 52 · see citing works
Increased Circulating Concentrations and Augmented Myocardial Extraction of Osteoprotegerin in Heart Failure Due to Left Ventricular Pressure Overload
Helske, S., Kovanen, P. T., Lindstedt, K. A., Salmela, K. T., Lommi, J., Turto, H., Werkkala, K., & Kupari, M. M. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.10.015 · Cited by 47 · see citing works
Self-citation
Left Ventricular Hypertrophy and Clinical Outcomes Over 5 Years After TAVR
Gonzales, H. M., Douglas, P. S., Pîbarot, P., Hahn, R. T., Khalique, O. K., Jaber, W. A., Cremer, P. C., Weissman, N. J., Asch, F. M., Zhang, Y., et al. (2020) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2020.03.011 · Cited by 47 · see citing works
The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure
Werbner, B., Tavakoli‐Rouzbehani, O. M., Fatahian, A. N., & Boudina, S. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.42 · Cited by 44 · see citing works
Impact of Afterload Increase on Left Ventricular Myocardial Deformation Indices
Réant, P., Métras, A., Détaille, D., Reynaud, A., Diolez, P., Jaspard‐Vinassa, B., Roudaut, R. P., Ouattara, A., Barandon, L., Santos, P. D. D., et al. (2016) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2016.09.006 · Cited by 45 · see citing works
Echocardiographic Assessment of Cardiac Structural and Functional Abnormalities in Patients With End-Stage Renal Disease Receiving Chronic Hemodialysis
Matsuo, H., Dohi, K., Machida, H., Takeuchi, H., Aoki, T., Nishimura, H., Yasutomi, M., Senga, M., Ichikawa, T., Kakuta, K., et al. (2017) · Circulation Journal · doi:10.1253/circj.cj-17-0393 · Cited by 45 · see citing works
Left Ventricular Mass Regression One Year After Transcatheter Aortic Valve Implantation
Tzikas, A., Geleijnse, M. L., Mieghem, N. M. V., Schultz, C. J., Nuis, R.-J. M., van Dalen, B. M., Sarno, G., van Domburg, R. T., Serruys, P. W. J. C., & de Jaegere, P. P. T. (2011) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2010.09.037 · Cited by 44 · see citing works
GDF-15 (Growth Differentiation Factor 15) Is Associated With Lack of Ventricular Recovery and Mortality After Transcatheter Aortic Valve Replacement
Kim, J. B., Kobayashi, Y., Moneghetti, K. J., Brenner, D. A., O’Malley, R., Schnittger, I., Wu, J. C., Murtagh, G., Beshiri, A., Fischbein, M. P., et al. (2017) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.117.005594 · Cited by 42 · see citing works
Evaluation of Tp‐E Interval and Tp‐E/QT Ratio in Patients with Aortic Stenosis
Yayla, Ç., Bilgin, M., Akboğa, M. K., Yayla, K. G., Canpolat, U., Asarcıklı, L. D., Doğan, M., Turak, O., Çay, S., Özeke, Ö., et al. (2015) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12298 · Cited by 41 · see citing works
Aortic morphological variability in patients with bicuspid aortic valve and aortic coarctation
Sophocleous, F., Biffi, B., Milano, E. G., Bruse, J. L., Caputo, M., Rajakaruna, C., Schievano, S., Emanueli, C., Bucciarelli‐Ducci, C., & Biglino, G. (2018) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezy339 · Cited by 41 · see citing works
Clinical outcome 5 to 18 years after the Fontan operation performed on children younger than 5 years
Robbers‐Visser, D., Kapusta, L., van Osch-Gevers, L. M., Strengers, J. L. M., Boersma, E. H., de Rijke, Y. B., Boomsma, F., Bogers, A. J. J. C., & Helbing, W. A. (2009) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.12.027 · Cited by 39 · see citing works
Left Ventricular Hypertrophy and Biomarkers of Cardiac Damage and Stress in Aortic Stenosis
Stein, E. J., Fearon, W. F., Elmariah, S., Kim, J. B., Kapadia, S. R., Kumbhani, D. J., Gillam, L., Whisenant, B., Quader, N., Zajarias, A., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.023466 · Cited by 41 · see citing works
Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress
Muthuramu, I., Singh, N., Amin, R., Nefyodova, E., Debasse, M., Horenbeeck, I. V., Jacobs, F., & Geest, B. D. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1281-3 · Cited by 38 · see citing works
Increased expression of profibrotic neutral endopeptidase and bradykinin type 1 receptors in stenotic aortic valves
Helske, S., Laine, M., Kupari, M. M., Lommi, J., Turto, H., Nurmi, L., Tikkanen, I. T., Werkkala, K., Lindstedt, K. A., & Kovanen, P. T. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm129 · Cited by 38 · see citing works
Self-citation
Circulating Level of miR-378 Predicts Left Ventricular Hypertrophy in Patients with Aortic Stenosis
Chen, Z., Li, C., Xu, Y., Li, Y., Yang, H., & Rao, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105702 · Cited by 36 · see citing works
Myocardial efficiency is an important determinant of functional improvement after aortic valve replacement in aortic valve stenosis patients: a combined PET and CMR study
Güçlü, A., Knaapen, P., Harms, H. J., Vonk, A. B. A., Stooker, W., Groepenhoff, H., Lammertsma, A. A., van Rossum, A. C., Germans, T., & van der Velden, J. (2015) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jev009 · Cited by 36 · see citing works
Factors affecting left ventricular remodeling after valve replacement for aortic stenosis. An overview
Villa, E., Troise, G., Cirillo, M., Brunelli, F., Tomba, M. D., Mhagna, Z., Tasca, G., & Quaini, E. (2006) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-4-25 · Cited by 34 · see citing works
Cardiac Microvascular Endothelial Cells in Pressure Overload–Induced Heart Disease
Trenson, S., Hermans, H., Craps, S., Pokreisz, P., de Zeeuw, P., Wauwe, J. V., Gillijns, H., Veltman, D., Wei, F., Caluwé, E., et al. (2021) · Circulation Heart Failure · doi:10.1161/circheartfailure.120.006979 · Cited by 32 · see citing works
Left ventricular remodelling patterns in patients with moderate aortic stenosis
Stassen, J., Ewe, S. H., Hirasawa, K., Butcher, S. C., Singh, G. K., Amanullah, M. R., Sin, K. Y. K., Ding, Z. P., Pio, S. M., Chew, N., et al. (2022) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeac018 · Cited by 30 · see citing works
Preoperative tissue Doppler imaging differentiates beneficial from detrimental left ventricular hypertrophy in patients with surgical aortic stenosis. A postoperative morbidity study
Bauer, F., Mghaieth, F., Dervaux, N., Donal, E., Dérumeaux, G., Cribier, A. G., & Bessou, J. P. (2008) · Heart · doi:10.1136/hrt.2007.121442 · Cited by 30 · see citing works
Discrepancies in Left Ventricular Mass Calculation Based on Echocardiography and Cardiovascular Magnetic Resonance Measurements in Patients with Left Ventricular Hypertrophy
Seo, H.-Y., Lee, S., Park, J.-B., Lee, J. M., Park, E.-A., Chang, S.-A., Kim, H.-K., Park, S.-J., Lee, W., Kim, Y.-J., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2015.06.009 · Cited by 27 · see citing works
Comparison of calcification potential of valvular interstitial cells isolated from individual aortic valve cusps
Masjedi, S., Amarnath, A., Baily, K. M., & Ferdous, Z. (2015) · Cardiovascular Pathology · doi:10.1016/j.carpath.2015.12.002 · Cited by 27 · see citing works
Pressure overload-induced right ventricular dysfunction and remodelling in experimental pulmonary hypertension: the right heart revisited
Pokreisz, P., Marsboom, G., & Janssens, S. P. (2007) · European Heart Journal Supplements · doi:10.1093/eurheartj/sum021 · Cited by 27 · see citing works
Rationale and design of the PRognostic Importance of MIcrovascular Dysfunction in asymptomatic patients with Aortic Stenosis (PRIMID-AS): a multicentre observational study with blinded investigations
Singh, A., Ford, I., Greenwood, J. P., Khan, J. N., Uddin, A., Berry, C., Neubauer, S., Prendergast, B., Jerosch‐Herold, M., Williams, B., et al. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-004348 · Cited by 26 · see citing works
Markers of left ventricular decompensation in aortic stenosis
Chin, C. W., Vassiliou, V. S., Jenkins, W. S. A., Prasad, S. K., Newby, D. E., & Dweck, M. R. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.923307 · Cited by 28 · see citing works
Outcome of Left-Sided Cardiac Remodeling in Severe Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Implantation
Magalhães, M. A., Koifman, E., Torguson, R., Minha, S., Gai, J., Kiramijyan, S., Escarcega, R. O., Baker, N. C., Wang, Z., Goldstein, S., et al. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.05.018 · Cited by 26 · see citing works
Is the use of renin–angiotensin system inhibitors in patients with aortic valve stenosis safe and of prognostic benefit? A systematic review and meta-analysis
Andersson, C., & Abdulla, J. (2016) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvw027 · Cited by 26 · see citing works
MicroRNA profiling identifies miR-7-5p and miR-26b-5p as differentially expressed in hypertensive patients with left ventricular hypertrophy
Kaneto, C. M., Nascimento, J. S., Moreira, M. C. R., Ludovico, N. D., Santana, A. P., Silva, R. A. A., Silva-Jardim, I., dos Santos, J. L., Sousa, S. M. B., & Lima, P. (2017) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20176211 · Cited by 24 · see citing works
Strain Assessment in Aortic Stenosis: Pathophysiology and Clinical Utility
Meredith, T., Roy, D. A., Hayward, C., Feneley, M. P., Kovacic, J. C., Muller, D. W., & Namasivayam, M. J. (2023) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2023.10.001 · Cited by 23 · see citing works
Calcific Aortic Valve Disease: Part 2—Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility
Pasipoularides, A. D. (2016) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-016-9695-z · Cited by 23 · see citing works
The Pathophysiology of Afterload Mismatch and Ventricular Hypertrophy
Carabello, B. A. (2021) · Structural Heart · doi:10.1080/24748706.2021.1944708 · Cited by 23 · see citing works
How Does the Heart Respond to Aortic Stenosis
Carabello, B. A. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.001242 · Cited by 23 · see citing works
Left Ventricular Remodeling in Degenerative Aortic Valve Stenosis
Abecasis, J., Pinto, D. G., Ramos, S., Masci, P. G., Cardim, N. M., Gil, V. M., & Félix, A. (2021) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2021.100801 · Cited by 22 · see citing works
Aortic Stenosis: A Contemporary Review
Sawaya, F., Liff, D. A., Stewart, J. T., Lerakis, S., Babaliaros, V. C., & Lerakis, S. (2012) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3182539d70 · Cited by 22 · see citing works
Is Blockade of the Renin-angiotensin System Able to Reverse the Structural and Functional Remodeling of the Left Ventricle in Severe Aortic Stenosis?
Suihko, S., Laine, M., Lommi, J., Kaartinen, M., Werkkala, K., Kovanen, P. T., & Kupari, M. M. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000182 · Cited by 22 · see citing works
Self-citation
Impact of Associated Significant Aortic Regurgitation on Left Ventricular Remodeling and Hemodynamic Impairment in Severe Aortic Valve Stenosis
Popescu, A. C., Antonini‐Canterin, F., Enache, R., Nicolosi, G. L., Piazza, R., Faggiano, P. M., Cassin, M., Dimulescu, D. R., Ginghină, C., & Popescu, B. A. (2013) · Cardiology · doi:10.1159/000346623 · Cited by 22 · see citing works
Prognostic value of pre-procedural left ventricular strain for clinical events after transcatheter aortic valve implantation
Suzuki-Eguchi, N., Murata, M., Itabashi, Y., Shirakawa, K., Fukuda, M., Endo, J., Tsuruta, H., Arai, T., Hayashida, K., Shimizu, H., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205190 · Cited by 21 · see citing works
The role of cardiac biochemical markers in aortic stenosis
Chin, C., Djohan, A. H., & Lang, C. C. (2016) · Biomarkers · doi:10.3109/1354750x.2016.1141993 · Cited by 22 · see citing works
Echocardiographic predictors of left ventricular functional recovery following valve replacement surgery for severe aortic stenosis
Ding, W., Lam, Y., Kaya, M. G., Li, W., Chung, R., Pepper, J., & Henein, M. Y. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.05.025 · Cited by 20 · see citing works
Patterns of Left Ventricular Remodeling in Aortic Stenosis: Therapeutic Implications
Elmariah, S. (2015) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-015-0391-0 · Cited by 20 · see citing works
Early hemodynamic changes after transcatheter aortic valve implantation in patients with severe aortic stenosis measured by invasive pressure volume loop analysis
Seppelt, P. C., Rosa, R. D., Mas‐Peiró, S., Zeiher, A. M., & Vasa‐Nicotera, M. (2020) · Cardiovascular Intervention and Therapeutics · doi:10.1007/s12928-020-00737-4 · Cited by 19 · see citing works
Bicuspid aortic valve in pregnancy
Yuan, S. (2014) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2013.06.018 · Cited by 19 · see citing works
Plasma Fibulin‐1 Is Linked to Restrictive Filling of the Left Ventricle and to Mortality in Patients With Aortic Valve Stenosis
Dahl, J. S., Møller, J. E., Videbæk, L. M., Poulsen, M. K., Rudbæk, T. R., Pellikka, P. A., Argraves, W. S., & Rasmussen, L. M. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.003889 · Cited by 18 · see citing works
Impact of gender on outcomes after transcatheter aortic valve implantation
Yousif, N., Obeid, S., Binder, R. K., Denegri, A., Shahin, M., Templin, C., & Lüscher, T. F. (2018) · Europe PMC (PubMed Central) · doi:10.5167/uzh-162642 · Cited by 18 · see citing works
Transcatheter aortic valve replacement (TAVR) leads to an increase in the subendocardial viability ratio assessed by pulse wave analysis
Müller, C., Goliasch, G., Schachinger, S., Kastl, S., Neunteufl, T., Delle‐Karth, G., Kästner, J., Gyöngyösi, M., Lang, I. M., Gottsauner‐Wolf, M., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207537 · Cited by 18 · see citing works
The impact of global left ventricular afterload on left ventricular reverse remodeling after aortic valve replacement
Ito, H., Mizumoto, T., Shomura, Y., Sawada, Y., Kajiyama, K., & Shimpo, H. (2017) · Journal of Cardiac Surgery · doi:10.1111/jocs.13190 · Cited by 17 · see citing works
Cardiac Adaptation to Volume Overload
Melenovský, V. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5203-4_9 · Cited by 17 · see citing works
Echocardiographic and Histologic Correlations in Patients with Severe Aortic Stenosis: Influence of Overweight and Obesity
Ávila‐Vanzzini, N., Fritche‐Salazar, J. F., Vázquez-Castro, N. M., Rivera-Lara, P., Pérez-Méndez, O. A., Martínez-Herrera, H., Gómez-Sánchez, M., Aranda‐Frausto, A., Herrera-Bello, H., Luna‐Luna, M., et al. (2016) · Journal of Cardiovascular Ultrasound · doi:10.4250/jcu.2016.24.4.303 · Cited by 16 · see citing works
Predicting and measuring mortality risk after transcatheter aortic valve replacement
Gupta, T., Joseph, D. T., Goel, S. S., & Kleiman, N. S. (2021) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2021.1888715 · Cited by 15 · see citing works
Circulatory efficiency in patients with severe aortic valve stenosis before and after aortic valve replacement
Nordmeyer, S., Lee, C. B., Goubergrits, L., Knosalla, C., Berger, F. F., Falk, V., Ghorbani, N., Hireche-Chikaoui, H., Zhu, M., Kelle, S., et al. (2021) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-020-00686-0 · Cited by 15 · see citing works
Impact of Valvuloarterial Impedance on Concentric Remodeling in Aortic Stenosis and Its Regression after Valve Replacement
Jang, J. Y., Seo, J.-S., Sun, B. J., Kim, D., Song, J., Kang, D., & Song, J. (2016) · Journal of Cardiovascular Ultrasound · doi:10.4250/jcu.2016.24.3.201 · Cited by 15 · see citing works
Cytokines profile of reverse cardiac remodeling following transcatheter aortic valve replacement
Kim, J. B., Kobayashi, Y., Kuznetsova, T., Moneghetti, K. J., Brenner, D. A., O'Malley, R., Dao, C. N., Wu, J. C., Fischbein, M. P., Miller, D. C., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.05.020 · Cited by 15 · see citing works
Established and emerging vascular risk factors and the development of aortic stenosis: an opportunity for prevention?
Τζιόμαλος, Κ., Athyros, V. G., Karagiannis, A. I., & Mikhailidis, D. P. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.7.809 · Cited by 15 · see citing works
Transcardiac gradients of circulating apelin: extraction by normal hearts vs. release by hearts failing due to pressure overload
Helske, S., Kovanen, P. T., Lommi, J., Turto, H., & Kupari, M. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00474.2010 · Cited by 15 · see citing works
Self-citation
Ascending aorta dilatation in patients with bicuspid aortic valve stenosis: a prospective CMR study
Rossi, A., van der Linde, D., Yap, S., Lapinskas, T., Kirschbaum, S. W., Springeling, T., Witsenburg, M., Cuypers, J. A. A. E., Moelker, A. D., Krestin, G. P., et al. (2012) · European Radiology · doi:10.1007/s00330-012-2651-7 · Cited by 14 · see citing works
Hemodynamic Changes During Physiological and Pharmacological Stress Testing in Healthy Subjects, Aortic Stenosis and Aortic Coarctation Patients–A Systematic Review and Meta-Analysis
Runte, K., Brosien, K., Salcher‐Konrad, M., Schubert, C., Goubergrits, L., Kelle, S., Schubert, S., Berger, F. F., Kühne, T., & Kelm, M. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00043 · Cited by 14 · see citing works
Left ventricular mass regression after sutureless implantation of the Perceval S aortic valve bioprosthesis: preliminary results
Santarpino, G., Pfeiffer, S., Pollari, F., Concistrè, G., Vogt, F. A., & Fischlein, T. J. M. (2013) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivt362 · Cited by 14 · see citing works
Congenital valvular aortic stenosis in young adults: Predictors for rate of progression of stenosis and aortic dilatation
van der Linde, D., Andrinopoulou, E.-R., Oechslin, E. N., Budts, W., van Dijk, A. P. J., Pieper, P. G., Wajon, E. M. C. J., Post, M. C., Witsenburg, M., Silversides, C. K., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.027 · Cited by 14 · see citing works
Sad Heart From No SOD
Góngora, M. C., & Harrison, D. G. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.101162 · Cited by 14 · see citing works
Advances in the Understanding of the Pathophysiology and Management of Aortic Stenosis: Role of Novel Imaging Techniques
Singh, A., Steadman, C. D., & McCann, G. P. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.03.008 · Cited by 13 · see citing works
Epicardial adipose tissue volume is associated with left ventricular remodelling in calcific aortic valve stenosis
Arangalage, D., Mathieu, T., Nguyen, V., Cimadevilla, C., Kerneis, C., Duval, X., Tubiana, S., Hyafil, F., Ou, P., Tribouilloy, C. M., et al. (2019) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2019.06.005 · Cited by 13 · see citing works
Antihypertensive therapies in moderate or severe aortic stenosis: a systematic review and meta-analysis
Sen, J., Chung, E., Neil, C., & Marwick, T. H. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-036960 · Cited by 13 · see citing works
Noninvasive cardiac output monitoring during general anesthesia for Cesarean delivery in a patient with severe aortic stenosis
Fanning, N., Balki, M., Sermer, M., Colman, J. M., & Carvalho, J. C. A. (2011) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-011-9537-z · Cited by 13 · see citing works
Influence of Myocardial Fibrosis on Left Ventricular Hypertrophy in Patients with Symptomatic Severe Aortic Stenosis
Golia, G., Milano, A. D., Dodonov, M., Bergamini, C., Faggian, G. G., Tomezzoli, A., & Vassanelli, C. (2011) · Cardiology · doi:10.1159/000334792 · Cited by 13 · see citing works

Is left ventricular hypertrophy a friend or foe of patients with aortic stenosis?
Davies, C., Zerebiec, K. W., Rożanowska, A., Czestkowska, E., Długosz, D., Chyrchel, B., & Surdacki, A. (2018) · Advances in Interventional Cardiology · doi:10.5114/aic.2018.78734 · Cited by 8 · see citing works
Prevalence of Left Ventricular Hypertrophy Caused by Systemic Hypertension Preceding the Development of Severe Aortic Stenosis
Aldrugh, S., Valle, J. E., Parker, M. W., Harrington, C. M., & Aurigemma, G. P. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.03.036 · Cited by 12 · see citing works
Absence of left ventricular hypertrophy in severe isolated aortic stenosis and preserved left ventricular systolic function.
Barasch, E., Kahn, J., Petillo, F., Pollack, S. Z., Rhee, P. D.-Y., & Reichek, N. (2014) · PubMed · Cited by 8 · see citing works
Left ventricular systolic function in aortic stenosis
Krayenbuehl, H. P., Hess, O. M., Ritter, M., Monrad, E. S., & Hoppeler, H. (1988) · European Heart Journal · doi:10.1093/eurheartj/9.suppl_e.19 · Cited by 94 · see citing works
Better Myocardial Function in Aortic Stenosis with Low Left Ventricular Mass: A Mechanism of Protection against Heart Failure Regardless of Stenosis Severity?
Chyrchel, B., Bolt, K., Długosz, D., Urbanska, A. S., Nowak-Kępczyk, M., Bałata, J., Rożanowska, A., Czestkowska, E., Kruszelnicka, O., & Surdacki, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111836 · Cited by 1 · see citing works

Authors: Kupari, M., Turto, H., & Lommi, J.
Affiliations: Helsinki University Hospital (FI)
Corresponding author: Kupari, Markku
ORCID: Kupari, Markku
Lommi, Jyri
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2005-04-28
Volume: 26
Issue: 17
Pages: 1790-1796
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehi290
OpenAlex: W2123889844
Cited by: 233
References: 40
Citations by year: 2026: 6 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 15 · 2019: 15 · 2018: 16 · 2017: 14 · 2016: 11 · 2015: 14 · 2014: 16 · 2013: 17 · 2012: 16
FWCI: 5.02
Type: journal article
Language: en
Open access: closed
Locations: European Heart Journal (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Foundation for Cardiovascular Research
Helsingin ja Uudenmaan Sairaanhoitopiiri
Sydäntutkimussäätiö
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Keywords: aortic stenosis, left ventricular hypertrophy, left ventricular mass, heart failure, systolic dysfunction, ejection fraction, valvular obstruction, maladaptive hypertrophy, compensatory response
MeSH terms: Adaptation, Physiological, Adult, Aged, Aged, 80 and over, Aortic Valve Stenosis, Female, Cardiac Catheterization, Heart Failure, Hemodynamics, Humans, Male, Middle Aged, Postoperative Period, Stroke Volume, Ultrasonography, Hypertrophy, Left Ventricular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure?

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks