Cited by 941Trypanosoma species research and implicationsResearch on Leishmaniasis StudiesVector-borne infectious diseases

The DOI matches its Crossref record; 298 of the 300 references it cites were found in a registry or an index.

Human African trypanosomiasis

Brun, Reto, Blum, Johannes, Chappuis, Francois, Burri, Christian·2010·The Lancet

DOI 10.1016/s0140-6736(09)60829-1

Open this paper in CoChat — free account

Abstract

Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(09)60829-1

Cites

298 of 298 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Items 201–298 of 298

The elimination of Trypanosoma brucei gambiense sleeping sickness in the focus of Luba, Bioko Island, Equatorial Guinea
Simarro, P. P., Franco, J. R., Ndongo, P. Y., Nguema, E., Louis, F. J., & Jannin, J. G. (2006) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2006.01624.x · Cited by 39
Human African trypanosomiasis: MRI
Sabbah, P., Brosset, C., Imbert, P., Bonardel, G., Jeandel, P. Y., & Briant, J. F. (1997) · Neuroradiology · doi:10.1007/s002340050491 · Cited by 39
Evaluation of LATEX/T.b.gambiense for mass screening of Trypanosoma brucei gambiense sleeping sickness in Central Africa
Penchenier, L., Grébaut, P., Njokou, F., Eyenga, V. E., & Büscher, P. (2002) · Acta Tropica · doi:10.1016/s0001-706x(02)00232-2 · Cited by 39
Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of Congo
Balasegaram, M. (2006) · Bulletin of the World Health Organization · doi:10.2471/blt.05.028399 · Cited by 39
Human African Trypanosomiasis in Areas without Surveillance
Chappuis, F., Lima, M. A., Flévaud, L., & Ritmeijer, K. (2010) · Emerging infectious diseases · doi:10.3201/eid1602.090967 · Cited by 38
Self-citation
Sleeping Sickness Elimination in Sight: Time to Celebrate and Reflect, but Not Relax
Aksoy, S. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001008 · Cited by 38
Use of polymerase chain reaction in human African trypanosomiasis stage determination and follow-up.
Truc, P., Jamonneau, V., Cuny, G., & Frézil, J. L. (1999) · Europe PMC (PubMed Central) · Cited by 38
Future prospects for the chemotherapy of human trypanosomiasis
Jennings, F. W. (1990) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(90)90125-x · Cited by 37
Managing Tsetse Transmitted Trypanosomosis by Insecticide Treated Nets - an Affordable and Sustainable Method for Resource Poor Pig Farmers in Ghana
Bauer, B., Holzgrefe, B., Mahama, C., Baumann, M., Mehlitz, D., & Clausen, P.-H. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001343 · Cited by 37
Proteomic fingerprinting for the diagnosis of human African trypanosomiasis
Agranoff, D., Stich, A., Abel, P. M., & Krishna, S. (2005) · Trends in Parasitology · doi:10.1016/j.pt.2005.02.003 · Cited by 37
The pharmacokinetics of eflornithine (?-difluoromethylornithine) in patients with late-stage T.b. gambiense sleeping sickness
Na‐Bangchang, K., Doua, F., Konsil, J., Hanpitakpong, W., Kamanikom, B., & Kuzoe, F. A. S. (2004) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-004-0759-7 · Cited by 37
Detection and Characterization of Autoantibodies Directed against Neurofilament Proteins in Human African Trypanosomiasis
Ayed, Z., Brindel, I., Bouteille, B., Meirvenne, N. V., Doua, F., Houinato, D. S., Dumas, M., & Jauberteau, M. (1997) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1997.57.1.tm0570010001 · Cited by 37
Myocarditis in Trypanosoma rhodesiense infections
Koten, J. W., & de Raadt, P. (1969) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(69)90036-4 · Cited by 36
Pentamidine Dosage: A Base/Salt Confusion
Dorlo, T. P. C., & Kager, P. A. (2008) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000225 · Cited by 35
Improved detection of Trypanosoma brucei by lysis of red blood cells, concentration and LED fluorescence microscopy
Biéler, S., Matovu, E., Mitashi, P., Ssewannyana, E., Shamamba, S. K. B., Bessell, P. R., & Ndung’u, J. M. (2011) · Acta Tropica · doi:10.1016/j.actatropica.2011.10.016 · Cited by 35
Harbouring in the brain: A focus on immune evasion mechanisms and their deleterious effects in malaria and human African trypanosomiasis
Bisser, S., Ouwe‐Missi‐Oukem‐Boyer, O., Touré, F. S., Taoufiq, Z., Bouteille, B., Buguet, A., & Mazier, D. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.02.001 · Cited by 35
MR imaging findings in African trypansomiasis.
Gill, D. S., Chatha, D. S., & del Carpio-O’Donovan, R. (2003) · PubMed · Cited by 34
Clinical and biological evolution of human trypanosomiasis in Cote d'Ivoire
Jamonneau, V., Garcia, A., Frézil, J. L., N'Guessan, P., N'Dri, L., Sanon, R., Laveissière, C., & Truc, P. (2000) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034980020028004 · Cited by 33
Effect of Folic Acid and Betaine Supplementation on Flow-Mediated Dilation: A Randomized, Controlled Study in Healthy Volunteers
Olthof, M. R., Bots, M. L., Katan, M., & Verhoef, P. (2006) · PLoS Clinical Trials · doi:10.1371/journal.pctr.0010010 · Cited by 33
African sleeping sickness
Checchi, F., & Barrett, M. P. (2008) · BMJ · doi:10.1136/bmj.39505.490544.be · Cited by 32
Serodiagnosis of sleeping sickness in the Republic of the Congo: comparison of indirect immunofluorescent antibody test and card agglutination test
Noireau, F., Lemesre, J.-L., Nzoukoudi, M. Y., Louembet, M. T., Goûteux, J., & Frézil, J. L. (1988) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(88)90430-0 · Cited by 32
Pathology of African trypanosomiasis
Kristensson, K., & Bentivoglio, M. (1999) · Springer eBooks · doi:10.1007/978-2-8178-0857-4_9 · Cited by 31
Validité, coût et faisabilité de la mAECT et CTC comme tests de confirmation dans la détection de la Trypanosomiase Humaine Africaine
Lutumba, P. T., Robays, J., Bilenge, C. M. M., Kandé, V., Mumba, D., Büscher, P., Dujardin, B., & Boelaert, M. (2006) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2006.01591.x · Cited by 31
Isolation and propagation of Trypanosoma brucei gambiense from sleeping sickness patients in south Sudan
Maina, N. W., Oberle, M., Otieno, C., Kunz, C., Mäser, P., Ndung’u, J. M., & Brun, R. (2007) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2006.11.008 · Cited by 30
Self-citation
Preliminary evaluation of LATEX/T. b. gambiense and alternative versions of CATT/T. b. gambiense for the serodiagnosis of Human African Trypanosomiasis of a population at risk in Côte d’Ivoire: considerations for mass-screening
Jamonneau, V., Truc, P., Garcia, A., Magnus, E., & Büscher, P. (2000) · Acta Tropica · doi:10.1016/s0001-706x(00)00095-4 · Cited by 30
Trypanosoma brucei s.l.: Characterisation of stocks from Central Africa by PCR analysis of mobile genetic elements
Simo, G., Herder, S., Njiokou, F., Asonganyi, T., Tilley, A., & Cuny, G. (2005) · Experimental Parasitology · doi:10.1016/j.exppara.2005.04.001 · Cited by 30
Case 20-2002
Moore, A., Ryan, E. T., & Waldron, M. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmcpc010056 · Cited by 30
Biological diagnosis of human African trypanosomiasis
Meirvenne, N. V. (1999) · Springer eBooks · doi:10.1007/978-2-8178-0857-4_14 · Cited by 29
Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school children
Éperon, G., Schmid, C., Loutan, L., & Chappuis, F. (2006) · Acta Tropica · doi:10.1016/j.actatropica.2006.12.002 · Cited by 29
Self-citation
Melarsoprol-Free Drug Combinations for Second-Stage Gambian Sleeping Sickness: The Way to Go
Chappuis, F. (2007) · Clinical Infectious Diseases · doi:10.1086/522983 · Cited by 29
Self-citation
Dot Enzyme-Linked Immunosorbent Assay for More Reliable Staging of Patients with Human African Trypanosomiasis
Courtioux, B., Bisser, S., Mbélesso, P., Ngoungou, E. B., Girard, M. F., Nangouma, A., Josenando, T., Jauberteau, M., & Bouteille, B. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.9.4789-4795.2005 · Cited by 29
Cost-effectiveness of Algorithms for Confirmation Test of Human African Trypanosomiasis
Lutumba, P. T., Meheus, F., Robays, J., Bilenge, C. M. M., Kandé, V., Büscher, P., Dujardin, B., & Boelaert, M. (2007) · Emerging infectious diseases · doi:10.3201/eid1310.060358 · Cited by 29
Human African trypanosomiasis: a latex agglutination field test for quantifying IgM in cerebrospinal fluid.
Lejon, V., Büscher, P., Sema, N. H., Magnus, E., & Meirvenne, N. V. (1998) · Europe PMC (PubMed Central) · Cited by 28
Candidate protein selection for diagnostic markers of African trypanosomiasis
Hutchinson, O. C., Webb, H., Picozzi, K., Welburn, S. C., & Carrington, M. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.08.007 · Cited by 28
Neuro-inflammatory risk factors for treatment failure in “early second stage” sleeping sickness patients treated with Pentamidine
Lejon, V. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.08.033 · Cited by 27
Detection of light subunit neurofilament and glial fibrillary acidic protein in cerebrospinal fluid of Trypanosoma brucei gambiense-infected patients.
Lejon, V., Rosengren, L., Büscher, P., Karlsson, J. E., & Sema, H. N. (1999) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1999.60.94 · Cited by 27
Responses of tsetse flies, Glossina morsitans morsitans and Glossina pallidipes , to baits of various size
Torr, S. J., Chamisa, A., Vale, G. A., Lehane, M. J., & Lindh, J. M. (2011) · Medical and Veterinary Entomology · doi:10.1111/j.1365-2915.2011.00947.x · Cited by 26
African Trypanosomes: Intracellular Trafficking of Host Defense Molecules1
Shiflett, A. M., Faulkner, S. D., Cotlin, L., Widener, J., Stephens, N. A., & Hajduk, S. L. (2006) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2006.00228.x · Cited by 25
A Traveler Returning from Central Africa with Fever and a Skin Lesion
Iborra, C., Danis, M., Bricaire, F., & Caumes, É. (1999) · Clinical Infectious Diseases · doi:10.1086/517213 · Cited by 25
A new in vitro test for human serum resistance of Trypanosoma (T.) brucei.
Jenni, L., & Brun, R. (1982) · PubMed · Cited by 25
Self-citation
Handbook of Drugs for Tropical Parasitic Infections
Scheibel, L. W., Gustafsson, L. L., Beerman, B., & Abdi, Y. A. (1988) · Journal of Parasitology · doi:10.2307/3282242 · Cited by 25
Use of symptoms and signs for diagnosis of Trypanosoma brucei rhodesiense trypanosomiasis by rural health personnel.
Boatin, B. A., Wyatt, G. B., Wurapa, F., & Bulsara, M. K. (1986) · Europe PMC (PubMed Central) · Cited by 24
Efficience de différentes stratégies de détection de la Trypanosomiase Humaine Africaine àT. b. gambiense
Lutumba, P. T., Robays, J., Bilenge, C. M. M., Kandé, V., Simarro, P. P., Shaw, A. P. M., Dujardin, B., & Boelaert, M. (2005) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2005.01391.x · Cited by 24
Detection of T.b. rhodesiense Trypanosomes in Humans and Domestic Animals in South East Uganda by Amplification of Serum Resistance‐Associated Gene
Enyaru, J., Matovu, E., NERIMA, B., Akol, M., & Sebikali, C. G. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1373.041 · Cited by 24
Experience with nifurtimox in chronic Chagas' infection. Preliminary report.
Dh, W., & Rw, R. (1972) · PubMed · Cited by 24
[Trypanosomiasis from Trypanosoma brucei gambiense in the center of north-west Uganda. Evaluation of 5 years of control (1987-1991)].
Paquet, C., Castilla, J., Mbulamberi, D., Beaulieu, M. F., Etchegorry, M. G. G., & Moren, A. (1995) · PubMed · Cited by 23
Sleeping glands?—The role of endocrine disorders in sleeping sickness (T.b. gambiense Human African Trypanosomiasis)
Blum, J. A., Schmid, C., Hatz, C., Kazumba, L., Mangoni, P., Rutishauser, J., la Torre, A., & Burri, C. (2007) · Acta Tropica · doi:10.1016/j.actatropica.2007.07.004 · Cited by 23
Self-citation
Parasitological diagnosis of human African trypanosomiasis: a comparison of the QBC® and miniature anion-exchange centrifugation techniques
Truc, P., Jamonneau, V., N'Guessan, P., Diallo, P., & Garcia, A. (1998) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(98)91014-8 · Cited by 23
Characterization of di‐, tri‐ and tetranucleotide microsatellite markers with perfect repeats for Trypanosoma brucei and related species
Balmer, O., Palma, C., MacLeod, A., & Caccone, A. (2006) · Molecular Ecology Notes · doi:10.1111/j.1471-8286.2006.01297.x · Cited by 23
Field evaluation of the CATT/Trypanosoma brucei gambiense on blood‐impregnated filter papers for diagnosis of human African trypanosomiasis in southern Sudan
Chappuis, F., Pittet, A., BOVIER, P. A., Adams, K., Godineau, V., Hwang, S. Y., Magnus, E., & Büscher, P. (2002) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.2002.00956.x · Cited by 23
Self-citation
Electrocardiographic changes in African trypanosomiasis caused by Trypanosoma brucei rhodesiense
Jones, I., Lowenthal, M., & Buyst, H. (1975) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(75)90194-7 · Cited by 22
Susceptibility of severe combined immuno‐deficient (SCID) mice to Trypanosoma brucei gambiense and T. b. rhodesiense
Inoue, Narumi, Mbati, Hirumi, Situakibanza, & Hirumi, H. (1998) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1998.00245.x · Cited by 22
Out of Africa
Sahlas, D. J., MacLean, J. D., Janevski, J., & Detsky, A. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmcps021049 · Cited by 22
[Sleeping sickness: major disorders of circadian rhythm].
Buguet, A., Bourdon, L., Bisser, S., Chapotot, F., Radomski, M. W., & Dumas, M. (2001) · PubMed · Cited by 22
Clinical pharmacokinetics of suramin in patients with onchocerciasis
Chijioke, C. P., Umeh, R. E., Mbah, A. U., Nwonu, P. C., Fleckenstein, L. L., & Okonkwo, P. O. (1998) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050454 · Cited by 21
Evaluation of Testryp CATT applied to samples of dried blood for the diagnosis of sleeping sickness.
Miezan, T., Doua, F., Cattand, P., & de Raadt, P. (1991) · Europe PMC (PubMed Central) · Cited by 20
Heritability of the trait for human infactivity in genetic crosses of Trypanosoma brucei ssp
Gibson, W. C., & Vh, M. (1997) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(97)90236-4 · Cited by 19
Susceptibility of Grammomys surdaster thicket rats to Trypanosoma brucei gambiense infection
Büscher, P., Shamamba, S., Ngoyi, D. M., Pyana, P. P., Baelmans, R., Magnus, E., & Overmeir, C. V. (2005) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2005.01468.x · Cited by 19
[Sleeping sickness: major disorders of circadian rhythm].
Buguet, A., Bourdon, L., Bisser, S., et al. (2001) · PubMed · Cited by 19
Gonadotropic axis and Trypanosoma brucei gambiense infection.
Boersma, A., Noireau, F., Hublart, M., Boutignon, F., Lemesre, J.-L., Racadot, A., & Degand, P. (1989) · PubMed · Cited by 19
African Trypanosomiasis Gambiense, Italy
Bisoffi, Z., Beltrame, A., Monteiro, G. B., Arzese, A., Marocco, S., Rorato, G., Anselmi, M., & Viale, P. (2005) · Emerging infectious diseases · doi:10.3201/eid1111.050649 · Cited by 18
Skin Features Accompanying Imported Human African Trypanosomiasis: HemolymphaticTrypanosoma gambienseInfection Among Two French Expatriates With Dermatologic Manifestations
Ezzedine, K., Darie, H., Bras, M. L., & Malvy, D. J.-M. (2007) · Journal of Travel Medicine · doi:10.1111/j.1708-8305.2007.00114.x · Cited by 18
APPLICATION OF NEW TECHNOLOGIES TO EPIDEMIOLOGY
Gibson, W. C., & Miles, M. (1985) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072037 · Cited by 18
The Programme Against African Trypanosomiasis Information System (Paatis)
Gilbert, M., Jenner, C., Pender, J., Rogers, D. J., Slingenbergh, J., & Wint, W. (2005) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46894-8_2 · Cited by 17
Enantioselective and Nonlinear Intestinal Absorption of Eflornithine in the Rat
Jansson‐Löfmark, R., Malm, M., Roth, C., & Ashton, M. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00050-08 · Cited by 17
Gambiense sleeping sickness: re-emerging and soon untreatable?
Nieuwenhove, S. V. (2000) · PubMed · doi:10.1590/s0042-96862000001100002 · Cited by 17
A new initiative for the development of new diagnostic tests for human African trypanosomiasis
Steverding, D. (2006) · Kinetoplastid Biology and Disease · doi:10.1186/1475-9292-5-1 · Cited by 17
Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001
Pépin, J., & Mpia, B. (2005) · Emerging infectious diseases · doi:10.3201/eid1106.050036 · Cited by 16
Clinical and serologic responses to human ‘apathogenic’ trypanosomes
Blum, J. A., Beck, B. R., Brun, R., & Hatz, C. (2005) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2005.04.010 · Cited by 16
Self-citation
Human African trypanosomiasis in Angola: clinical observations, treatment, and use of PCR for stage determination of early stage of the disease
Truc, P., Lando, A., Penchenier, L., Vatunga, G., & Josenando, T. (2011) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2011.10.002 · Cited by 15
Evaluation of an EDTA version of CATT/Trypanosoma bruceigambiense for serological screening of human blood samples
Magnus, E., Lejon, V., Bayon, D., Buyse, D., Simarro, P. P., Verloo, D., Vervoort, T., Pansaerts, R., Büscher, P., & Meirvenne, N. V. (2002) · Acta Tropica · doi:10.1016/s0001-706x(01)00184-x · Cited by 14
Evaluation of the Cost-Effectiveness of Pyramidal, Modified Pyramidal and Monoscreen Traps for the Control of the Tsetse Fly,Glossina fuscipes fuscipes, in Uganda
Abila, P. P., Okello-Onen, J., Okoth, J. O., Matete, G. O., Wamwiri, F. N., & Politzar, H. (2007) · Journal of Insect Science · doi:10.1673/031.007.4701 · Cited by 14
Sleeping Sickness in Brothers in London
Faust, S. N., Woodrow, C. J., Patel, S. K., Snape, M. D., Chiodini, P. L., Tudor‐Williams, G., & Lyall, E. G. H. (2004) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000137587.80399.3b · Cited by 14
Evidence for widespread asymptomatic Trypanosoma rhodesiense human infection in the Luangwa Valley (Zambia).
Songa, E. B., Hamers, R., Rickman, R., NANTULYA, V. M., Mulla, A. F., & Magnus, E. (1991) · PubMed · Cited by 14
[Psychiatric presentation of human African trypanosomiasis: overview of diagnostic pitfalls, interest of difluoromethylornithine treatment and contribution of magnetic resonance imaging].
Bédat-Millet, A.-L., Charpentier, S., MONGESTRAUSS, M., & Woimant, F. (2000) · PubMed · Cited by 14
Influence of a past history of Gambian sleeping sickness on physical growth, sexual maturity and academic performance of children in Fontem, Cameroon
Aroke, A. H. (1998) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034989858862 · Cited by 13
Human African trypanosomiasis: quantitative and qualitative assessment of intrathecal immune response
Lejon, V., Sindic, C. J. M., Antwerpen, M. P. V., Doua, F., Djé, N., Solano, P., Jamonneau, V., Wouters, I., & Büscher, P. (2003) · European Journal of Neurology · doi:10.1046/j.1468-1331.2003.00660.x · Cited by 13
Myocarditis in Rhodesiense trypanosomiasis.
de Raadt, P., & Koten, J. W. (1968) · PubMed · Cited by 13
[Sleeping sickness, forgotten illness: what are the consequences in the field?].
Pp, S., Fj, L., & Jannin, J. G. (2003) · PubMed · Cited by 13
Comparison of operational criteria for treatment outcome in gambiense human African trypanosomiasis
Ngoyi, D. M., Lejon, V., N’Siesi, F., Boelaert, M., & Büscher, P. (2009) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2009.02248.x · Cited by 12
Cryopreservation of Trypanosoma brucei gambiense in a commercial cryomedium developed for bull semen
Maina, N. W., Kunz, C., & Brun, R. (2006) · Acta Tropica · doi:10.1016/j.actatropica.2005.11.011 · Cited by 12
Self-citation
[Current aspects of the cardiac symptoms in African human trypanosomiasis due to Trypanosoma gambiense (apropos of 194 cases)].
Bertrand, E., Serie, F., Rive, J., Compaore, P., Sentilhes, L., Baudin, L., Renambot, J., Chauvet, J.-L., Ekra, A., & Assamoi, M. O. (1974) · PubMed · Cited by 12
[Functional and immunologic involvement in human African trypanosomiasis caused by Trypanosoma gambiense].
Tsala Mbala, P., Blackett, K. N., Cl, M., LEKE, R. J. I., & Etoundi, J. (1988) · PubMed · Cited by 12
[Sleeping sickness in children and its long term after-effects. Apropos 110 personal observations at Fontem Hospital (Cameroon)].
Cramet, R. (1982) · PubMed · Cited by 11
[Detection of trypanosomes in blood by the Quantitative Buffy Coat (QBC) technique: experimental evaluation].
Ancelle, T., Paugam, A., Bourlioux, F., Merad, A., & Vigier, J. P. (1997) · PubMed · Cited by 10
East African Trypanosomiasis
Oscherwitz, S. L. (2006) · Journal of Travel Medicine · doi:10.2310/7060.2003.31743 · Cited by 10
[Endocrine function and African trypanosomiasis. Evaluation of 79 cases].
Hublart, M., Lagouche, L., Racadot, A., Boersma, A., Degand, P., Noireau, F., Lemesre, J.-L., & Toudic, A. (1988) · PubMed · Cited by 10
Nifurtimox: causal treatment of Chagas' disease.
Gönnert, R. (1972) · PubMed · Cited by 10
Diagnosis of Rhodesian sleeping sickness in the Lambwe Valley (1980–1984)
Wellde, B. T., Chumo, D. A., Reardon, M. J., Nawiri, J., Olando, J., Wanyama, L., Awala, J., Koech, D., Siongok, T. A., & Sabwa, C. L. (1989) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034983.1989.11812410 · Cited by 10
The Human Trypanolytic Factor: A Drug Shaped Naturally
Vanhamme, L. (2010) · Infectious Disorders - Drug Targets · doi:10.2174/187152610791591566 · Cited by 7
Key indicators for the monitoring and evaluation of control programmes of human African trypanosomiasis due to Trypanosoma brucei gambiense
Bouchet, Legros, & Lee (1998) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1997.00258.x · Cited by 7
African trypanosomiasis: New insights for disease control
Sternberg, J., Black, S. J., & Magez, S. (2010) · Parasitology · doi:10.1017/s0031182010001435 · Cited by 7
[Three patients with African sleeping sickness following a visit to Tanzania].
Melo, M. D. M., Rasica, M., van Thiel, P. P. A. M., Richter, C., Kager, P. A., & Pj, W. (2002) · PubMed · Cited by 7
[Neuroimaging and efficacy of treatment in advanced African trypanosomiasis].
Serrano-González, C., Velilla, I., Fortuño, B., Guelbenzu, S., & Portolés, A. (1996) · PubMed · Cited by 6
[Three patients with African sleeping sickness following a visit to Tanzania].
Callens, S. F. J., van Wijngaerden, E., Clerinx, J., & Colebunders, R. (2003) · PubMed · Cited by 6
[Absence of epidemiologic interrelations between retroviral infection by HIV and human African trypanosomiasis (HAT)].
Jp, L., Jannin, J. G., Hengy, C., Moulia-Pelat, J. P., Makuwa, M., Asonganyi, T., Noutoua, L., Fadat, G., Nguerenemo, P., & Cattand, P. (1991) · PubMed · Cited by 6
[Rough start for the fight against sleeping sickness in French equatorial Africa].
Fj, L., & Pp, S. (2005) · PubMed · Cited by 3
Louise Pearce: A ‘Magic Bullet’ for African Sleeping Sickness
Bendiner, E. (1992) · Hospital Practice · doi:10.1080/21548331.1992.11705350 · Cited by 3

Research works printed but not linked: 4

Bronner U. Pharmacokinetics of pentamidine. Focus on treatment of Trypanosoma gambiense sleeping sickness. PhD thesis, Karolinska Institute, 1994.
Seixas J. Investigations on the encephalopathic syndrome during melarsoprol treatment of human African trypanosomiasis. PhD thesis, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 2004.
Chappuis, 2004, Eflornithine for the treatment of human African trypanosomiasis: practical perspectives, Dev Sante, 171, 41
African Union. Statement from the Commission of the African union to the AHP/DFID special workshop on: tsetse control—the next 100 years, Sept 9–10, 2002, Edinburgh, UK.

Sorted by citations

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32335-3 · Cited by 4,192
Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Hay, S. I., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32130-x · Cited by 2,083
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“In human African trypanosomiasis (HAT), a parasitic disease also known as sleeping sickness, circadian sleep-wake disruption is characteristic, with sleep and wake periods distributed throughout the 24-h day (77, 83).”
Background
Human African trypanosomiasis
Büscher, P., Cecchi, G., Jamonneau, V., & Priotto, G. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31510-6 · Cited by 711
Kinetoplastids: related protozoan pathogens, different diseases
Stuart, K., Brun, R., Croft, S. L., Fairlamb, A. H., Gürtler, R. E., McKerrow, J., Reed, S., & Tarleton, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33945 · Cited by 618
Self-citation

See all 941

Authors: Brun, R., Blum, J., Chappuis, F., & Burri, C.
Affiliations: Swiss Tropical and Public Health Institute (CH)
Corresponding author: Brun, Reto
ORCID: Blum, Johannes
Burri, Christian
Venue: The Lancet
Publisher: Elsevier BV
Published: 2010-01
Volume: 375
Issue: 9709
Pages: 148-159
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(09)60829-1
OpenAlex: W2151877638
Cited by: 926
References: 300
Citations by year: 2026: 20 · 2025: 20 · 2024: 35 · 2023: 40 · 2022: 35 · 2021: 47 · 2020: 39 · 2019: 50 · 2018: 49 · 2017: 69 · 2016: 71 · 2015: 78 · 2014: 74 · 2013: 85 · 2012: 85
FWCI: 45.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Medecins Sans Frontieres Field Research (Medecins Sans Frontieres) (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords: sleeping sickness, Trypanosoma brucei gambiense, tsetse flies, neglected tropical diseases, disease resurgence, political instability, vector control, disease elimination, clinical features, diagnosis, treatment, adverse drug reactions, sub-Saharan Africa
MeSH terms: Africa, Eflornithine, Animals, Communicable Disease Control, Humans, Insect Bites and Stings, Insect Vectors, Melarsoprol, Pentamidine, Suramin, Trypanocidal Agents, Trypanosoma brucei gambiense, Trypanosomiasis, African, Tsetse Flies, Variant Surface Glycoproteins, Trypanosoma, Incidence, Endemic Diseases, Biomedical Research

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human African trypanosomiasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks