Cited by 167HIV, Drug Use, Sexual RiskSubstance Abuse Treatment and OutcomesHIV/AIDS Research and Interventions

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Amphetamine-group substances and HIV

Colfax, Grant, Santos, Glenn-Milo, Chu, Priscilla, Vittinghoff, Eric, Pluddemann, Andreas, Kumar, Suresh, Hart, Carl·2010·The Lancet

DOI 10.1016/s0140-6736(10)60753-2

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Abstract

Amphetamine-group substances are used worldwide and are more prevalent than either cocaine or opioids. We reviewed published reports about amphetamine-group substances and did a meta-analysis of randomised controlled trials of behavioural interventions for their use. Most research was done in developed countries. Many, but not all, studies show an association between amphetamine-group substance use and risk of HIV infection. Much use of amphetamine-group substances is non-injection and is associated with increased HIV risk, particularly in men who have sex with men. The structural, social, interpersonal, and personal factors that link to amphetamine-group substance use and HIV risk are poorly understood. 13 studies, with a cumulative sample size of 1997 individuals, qualified for the meta-analysis. Overall, high-intensity behavioural interventions were moderately effective in reducing use of amphetamine-group substances (effect size 0.28, 95% CI 0.13-0.44). We did not find conclusive evidence that behavioural interventions as a group are more effective than are passive or minium treatment for reduction of amphetamine-group substance use or sexual risk behaviours. The search for effective, scalable, and sustainable interventions for amphetamine-group substance use, including pharmacotherapies, should be supported and encouraged.

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Authors: Colfax, G., Santos, G.-M., Chu, P., Vittinghoff, E., Pluddemann, A., Kumar, S., & Hart, C.
Affiliations: University of California, San Francisco (US)
San Francisco Department of Public Health (US)
Columbia University (US)
Corresponding author: Colfax, Grant
ORCID: Santos, Glenn-Milo
Vittinghoff, Eric
Kumar, Suresh
Hart, Carl
Venue: The Lancet
Publisher: Elsevier BV
Published: 2010-08
Volume: 376
Issue: 9739
Pages: 458-474
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(10)60753-2
OpenAlex: W2120564358
Cited by: 167
References: 137
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 13 · 2020: 13 · 2019: 10 · 2018: 11 · 2017: 10 · 2016: 13 · 2015: 17 · 2014: 14 · 2013: 18 · 2012: 14
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (R01DA022155, R01DA022190, R01DA023387)
Topics: Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: stimulant use, HIV risk, men who have sex with men, behavioral interventions, substance use reduction, sexual risk behavior, non-injection drug use, HIV prevention
MeSH terms: Behavior Therapy, Humans, Risk-Taking, Sexual Behavior, HIV Infections, Substance Abuse, Intravenous, Prevalence, Randomized Controlled Trials as Topic, Needle-Exchange Programs, Amphetamine-Related Disorders

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