Evaluating the impact of community‐based treatment options on methamphetamine use: findings from the M ethamphetamine T reatment E valuation S tudy (MATES)
Open accessAbstract
Aims: To evaluate the impact of community‐based drug treatment on methamphetamine use using inverse probability of treatment‐weighted (IPTW) estimators to derive treatment effects. Design: A longitudinal prospective cohort study with follow‐ups at 3 months, 1 year and 3 years. Treatment effects were derived by comparing groups at follow‐up. IPTW estimators were used to adjust for pre‐treatment differences between groups. Setting: S ydney and B risbane, A ustralia. Participants: Participants were methamphetamine users entering community‐based detoxification (n = 112) or residential rehabilitation (n = 248) services and a quasi‐control group of methamphetamine users (n = 101) recruited from the community. Measurements: Frequency of methamphetamine use between interviews (no use, less than weekly, 1–2 days per week, 3+ days per week), continuous abstinence from methamphetamine use, past month methamphetamine use and methamphetamine dependence. Findings: Detoxification did not reduce methamphetamine use at any follow‐up relative to the quasi‐control group. Relative to quasi‐control and detoxification groups combined, residential rehabilitation produced large reductions in the frequency of methamphetamine use at 3 months [odds ratio (OR) = 0.23, 95% confidence interval (CI) 0.15–0.36, P < 0.001), with a marked attenuation of this effect at 1 year (OR 0.62, 95% CI 0.40–0.97, P = 0.038) and 3 years (OR = 0.71, 95% CI 0.42–1.19, P = 0.189). The greatest impact was for abstinence: for every 100 residential rehabilitation clients there was a gain of 33 being continuously abstinent at 3 months, with this falling to 14 at 1 year and 6 at 3 years. Conclusions: Community‐based residential rehabilitation may produce a time‐limited decrease in methamphetamine use, while detoxification alone does not appear to do so.
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Other clinically available treatments for methamphetamine dependence, including long-stay residential rehabilitation, carry substantial constraints related to access, cost, and scalability.
“other clinically available treatments, including long-stay residential rehabilitation, carry substantial constraints related to access, cost, and scalability (7)”
From Psilocybin-assisted psychotherapy for methamphetamine dependence: a case report involving daily methamphetamine use (2024) · cites this paper as [7]
The Discussion (page unavailable) describes residential rehabilitation as having expensive running costs and questions whether its time-limited benefits outweigh them. The Participants and procedure section describes longer residential stays, but the paper does not establish constraints on access or scalability. It also does not extend those constraints to other clinically available treatments. (LLM, conf=0.86)
Experimental — accuracy not yet measuredResidential rehabilitation has significant cost, accessibility and acceptability constraints, with minimal impact on longer-term outcomes.
“Residential rehabilitation has significant cost, accessibility and acceptability constraints, with minimal impact on longer-term outcomes [11].”
From Psilocybin‐assisted psychotherapy for methamphetamine use disorder: A pilot open‐label safety and feasibility study. (2025) · cites this paper as [11]
The Discussion reports expensive running costs and a large but time-limited reduction in methamphetamine use; the Conclusion finds no clear benefit at three years. Our copy does not establish accessibility or acceptability constraints, and the longer-term finding concerns methamphetamine use in this study rather than outcomes generally. (LLM, conf=0.88)
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- Authors
- McKetin, R., Najman, J. M., Baker, A. L., Lubman, D. I., Dawe, S., Ali, R., Lee, N. K., Mattick, R. P., & Mamun, A.
- Affiliations
- Australian National University (AU)
- The University of Queensland (AU)
- University of Newcastle Australia (AU)
- Eastern Health (AU)
- Griffith University (AU)
- The University of Adelaide (AU)
- Flinders University (AU)
- UNSW Sydney (AU)
- Corresponding author
- McKetin, Rebecca
- ORCID
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2012-07-12
- Volume
- 107
- Issue
- 11
- Pages
- 1998-2008
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- OpenAlex
- W1924347018
- Cited by
- 147
- References
- 35
- Citations by year
- 2026: 2 · 2025: 14 · 2024: 16 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 9 · 2019: 11 · 2018: 14 · 2017: 14 · 2016: 15 · 2015: 8 · 2014: 9 · 2013: 5 · 2012: 1
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Addiction (publishedVersion)
- PubMed (publishedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- Figshare (submittedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Griffith Research Online (submittedVersion)
- Funders
- Australian Government
- University of New South Wales
- Medical Research Council
- National Health and Medical Research Council
- National Drug and Alcohol Research Centre
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Keywords
- methamphetamine use, community-based drug treatment, residential rehabilitation, detoxification, treatment effects, abstinence, methamphetamine dependence, addiction treatment, inverse probability of treatment weighting
- MeSH terms
- Adult, Female, Humans, Longitudinal Studies, Male, Methamphetamine, Recurrence, Residential Treatment, Case-Control Studies, Treatment Outcome, Amphetamine-Related Disorders
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