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Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)
Open accessAbstract
Background Sickle cell anaemia (SCA) is associated with significant morbidity from acute complications and organ dysfunction beginning in the first year of life. In the first multicenter randomised double-blinded trial in very young children with SCA, the impact of hydroxyurea (hydroxycarbamide) therapy on organ dysfunction, clinical complications, and laboratory findings, and its toxicity, were examined. Methods Eligible subjects had HbSS or Sβ0thalassaemia, were age 9–18 months at randomisation, and were not selected for clinical severity. Subjects received liquid hydroxyurea, 20 mg/kg/day, or placebo for two years. Primary study endpoints were splenic function (qualitative uptake on 99Tc spleen scan) and renal function (glomerular filtration rate by 99mTc-DTPA clearance). Additional evaluations included: blood counts, HbF, chemistry profiles, spleen function biomarkers, urine osmolality, neurodevelopment, transcranial Doppler ultrasonography, growth, and mutagenicity. Study visits occurred every two to four weeks. Findings Ninety-six subjects received hydroxyurea and 97 placebo; 86% completed the study. Significant differences were not seen for the primary endpoints, but suggestive benefit was noted in quantitative measures of spleen function. Hydroxyurea significantly decreased pain and dactylitis with trends for decreased acute chest syndrome, hospitalisation and transfusion. Hydroxyurea increased haemoglobin and HbF and decreased WBC count. Toxicity was limited to mild-moderate neutropaenia. Interpretation Although hydroxyurea treatment did not reduce splenic and renal dysfunction assessed by primary endpoint measures, it resulted in major clinical benefit because of diminished acute complications, favorable haematologic results, and a lack of unexpected toxicities. Based on the safety and efficacy data from this trial, hydroxyurea can now be considered for all very young children with SCA.
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“In contrast, all children seem to have a robust HbF response to hydroxyurea that retards the natural age-related fall in HbF.87”
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Citations
Cites
Cox’s regression model for counting processes: A large sample study
Andersen, P. K., & Gill, R. D. (1982) · The Annals of Statistics · doi:10.1214/aos/1176345976 · Cited by 4,419
Mortality in sickle cell disease. Life expectancy and risk factors for early death
Platt, O. S., Brambilla, D. J., Rosse, W. F., Milner, P. F., Castro, O., Steinberg, M. H., & Klug, P. P. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406093302303 · Cited by 3,320
Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia
Charache, S., Terrin, M. L., Moore, R. D., Dover, G. J., Barton, F. B., Eckert, S. V., McMahon, R. P., & Bonds, D. R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322001 · Cited by 2,340
Pain in Sickle Cell Disease: Rates and Risk Factors
Platt, O. S., Thorington, B. D., Brambilla, D. J., Milner, P. F., Rosse, W. F., Vichinsky, E., & Kinney, T. R. (1991) · New England Journal of Medicine · doi:10.1056/nejm199107043250103 · Cited by 1,546
Prediction of Adverse Outcomes in Children with Sickle Cell Disease
Miller, S. T., Sleeper, L. A., Pegelow, C. H., Enos, L. E., Wang, W. C., Weiner, S. J., Wethers, D. L., Smith, J., & Kinney, T. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200001133420203 · Cited by 508
Self-citationThe risks and benefits of long-term use of hydroxyurea in sickle cell anemia: a 17.5 year follow-up
Steinberg, M. H., McCarthy, W. F., Castro, O., Ballas, S. K., Armstrong, F. D., Smith, W., Ataga, K., Swerdlow, P., Kutlar, A., DeCastro, L., et al. (2010) · American Journal of Hematology · doi:10.1002/ajh.21699 · Cited by 486
Self-citationVoskaridou, E., Christoulas, D., Bilalis, A., Plata, E., Varvagiannis, K., Stamatopoulos, G., Sinopoulou, K., Balassopoulou, A., Loukopoulos, D., & Terpos, E. (2010) · Blood · doi:10.1182/blood-2009-05-221333 · Cited by 430
How I use hydroxyurea to treat young patients with sickle cell anemia
Ware, R. E. (2010) · Blood · doi:10.1182/blood-2009-04-146852 · Cited by 406
Self-citationZimmerman, S. A., Schultz, W. H., Davis, J. S., Pickens, C. V., Mortier, N. A., Howard, T. A., & Ware, R. E. (2003) · Blood · doi:10.1182/blood-2003-07-2475 · Cited by 312
Self-citationSystematic Review: Hydroxyurea for the Treatment of Adults with Sickle Cell Disease
Lanzkron, S., Strouse, J. J., Wilson, R. F., Beach, M. C., Haywood, C., Park, H., Witkop, C., Bass, E. B., & Segal, J. B. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-12-200806170-00221 · Cited by 288
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Rees, D. C., Williams, T. N., & Gladwin, M. T. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61029-x · Cited by 2,504
Management of Sickle Cell Disease: Summary of the 2014 Evidence-Based Report by Expert Panel Members
Yawn, B. P., Buchanan, G. R., Afenyi-Annan, A. N., Ballas, S. K., Hassell, K. L., James, A. H., Jordan, L., Lanzkron, S. M., Lottenberg, R., Savage, W. J., et al. (2014) · JAMA · doi:10.1001/jama.2014.10517 · Cited by 1,599
Self-citationKato, G. J., Piel, F. B., Reid, C. D., Gaston, M. H., Ohene-Frempong, K., Krishnamurti, L., Smith, W. R., Panepinto, J. A., Weatherall, D. J., Costa, F. F., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.10 · Cited by 1,501
Ware, R. E., de Montalembert, M., Tshilolo, L. M., & Abboud, M. R. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30193-9 · Cited by 1,036
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Akinsheye, I., Alsultan, A., Solovieff, N., Ngo, D., Baldwin, C. T., Sebastiani, P., Chui, D. H. K., & Steinberg, M. H. (2011) · Blood · doi:10.1182/blood-2011-03-325258 · Cited by 553
Ware, R. E., Davis, B. R., Schultz, W. H., Brown, R. C., Aygun, B., Sarnaik, S., Odame, I., Fuh, B., George, A., Owen, W., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01041-7 · Cited by 515
Self-citationGluckman, É., Cappelli, B., Bernaudin, F., Labopin, M., Volt, F., Carreras, J., Simões, B. P., Ferster, A., Dupont, S., de la Fuente, J., et al. (2016) · Blood · doi:10.1182/blood-2016-10-745711 · Cited by 496
Kavanagh, P. L., Fasipe, T., & Wun, T. (2022) · JAMA · doi:10.1001/jama.2022.10233 · Cited by 522
Rezvan, P. H., Lee, K. J., & Simpson, J. A. (2015) · BMC Medical Research Methodology · doi:10.1186/s12874-015-0022-1 · Cited by 483
Angelucci, E., Matthes‐Martin, S., BARONCIANI, D., Bernaudin, F., Bonanomi, S., Cappellini, M. D., Dalle, J., Bartolomeo, P. D., de Heredia, C. D., Dickerhoff, R., et al. (2014) · Haematologica · doi:10.3324/haematol.2013.099747 · Cited by 404
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Ware, R. E., & Helms, R. W. (2012) · Blood · doi:10.1182/blood-2011-11-392340 · Cited by 385
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Tshilolo, L., Tomlinson, G., Williams, T. N., Santos, B., Olupot-Olupot, P., Lane, A., Aygun, B., Stuber, S. E., Latham, T. S., McGann, P. T., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1813598 · Cited by 376
Self-citationBushnell, C., Kernan, W. N., Sharrief, A. Z., Chaturvedi, S., Cole, J. W., Cornwell, W. K., Cosby-Gaither, C., Doyle, S., Goldstein, L. B., Lennon, O. C., et al. (2024) · Stroke · doi:10.1161/str.0000000000000475 · Cited by 443
Hydroxyurea therapy for sickle cell anemia
McGann, P. T., & Ware, R. E. (2015) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2015.1088827 · Cited by 320
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Brousse, V. A. M., Buffet, P. A., & Rees, D. C. (2014) · British Journal of Haematology · doi:10.1111/bjh.12950 · Cited by 291
Sickle cell disease related mortality in the United States (1999-2009)
Hamideh, D., & Alvarez, O. A. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24557 · Cited by 290
Klings, E. S., Machado, R. F., Barst, R. J., Morris, C. R., Mubarak, K. K., Gordeuk, V. R., Kato, G. J., Ataga, K. I., Gibbs, J. S. R., Castro, O. L., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201401-0065st · Cited by 264
Impact of hydroxyurea on clinical events in the BABY HUG trial
Thornburg, C. D., Files, B. A., Luo, Z., Miller, S. T., Kalpatthi, R. V., Iyer, R. V., Seaman, P., Lebensburger, J. D., Alvarez, O. A., Thompson, B., et al. (2012) · Blood · doi:10.1182/blood-2012-03-419879 · Cited by 256
Self-citationSickle cell disease: a neglected chronic disease of increasing global health importance
Chakravorty, S., & Williams, T. N. (2014) · Archives of Disease in Childhood · doi:10.1136/archdischild-2013-303773 · Cited by 237
Mechanisms of haemolysis-induced kidney injury
Avondt, K. V., Nur, E., & Zeerleder, S. S. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0181-0 · Cited by 209
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Aygün, B., & Odame, I. (2012) · Pediatric Blood & Cancer · doi:10.1002/pbc.24175 · Cited by 211
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Howard, J. (2016) · Hematology · doi:10.1182/asheducation-2016.1.625 · Cited by 197
Ballas, S. K., Kesen, M. R., Goldberg, M. F., Lutty, G. A., Dampier, C., Osunkwo, I., Wang, W. C., Hoppe, C. C., Hagar, W., Darbari, D. S., et al. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/949535 · Cited by 198
Self-citationRecent Advances in the Treatment of Sickle Cell Disease
Cisneros, G. S., & Thein, S. L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00435 · Cited by 210
Chaturvedi, S., & DeBaun, M. R. (2015) · American Journal of Hematology · doi:10.1002/ajh.24235 · Cited by 200
Guideline on the management of acute chest syndrome in sickle cell disease
Howard, J., Hart, N., Roberts-Harewood, M., Cummins, M., Awogbade, M., & Davis, B. A. (2015) · British Journal of Haematology · doi:10.1111/bjh.13348 · Cited by 186
Piel, F. B., Rees, D. C., DeBaun, M. R., Nnodu, O. E., Ranque, B., Thompson, A. A., Ware, R. E., Abboud, M. R., Abraham, A., Ambrose, E. E., et al. (2023) · The Lancet Haematology · doi:10.1016/s2352-3026(23)00096-0 · Cited by 203
Self-citationTrends in Sickle Cell Disease–Related Mortality in the United States, 1979 to 2017
Payne, A. B., Mehal, J. M., Chapman, C., Haberling, D. L., Richardson, L. C., Bean, C. J., & Hooper, W. C. (2020) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2020.08.009 · Cited by 174
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Nevitt, S. J., Jones, A. P., & Howard, J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002202.pub2 · Cited by 170
Novelli, E. M., & Gladwin, M. T. (2015) · CHEST Journal · doi:10.1016/j.chest.2015.12.016 · Cited by 166
Lê, P.-Q., Gulbis, B., Dedeken, L., Dupont, S., Vanderfaeillie, A., Heijmans, C., Huybrechts, S., Devalck, C., Efira, A., Dresse, M., et al. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25608 · Cited by 164
Ware, R. E., Despotovic, J. M., Mortier, N. A., Flanagan, J. M., He, J., Smeltzer, M. P., Kimble, A. C., Aygün, B., Wu, S., Howard, T. A., et al. (2011) · Blood · doi:10.1182/blood-2011-07-364190 · Cited by 163
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John, C. C., Opoka, R. O., Latham, T. S., Hume, H. A., Nabaggala, C., Kasirye, P., Ndugwa, C. M., Lane, A., & Ware, R. E. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2000146 · Cited by 153
Self-citationOpoka, R. O., Ndugwa, C. M., Latham, T., Lane, A., Hume, H. A., Kasirye, P., Hodges, J. S., Ware, R. E., & John, C. C. (2017) · Blood · doi:10.1182/blood-2017-06-788935 · Cited by 151
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Bernaudin, F., Dalle, J., Bories, D., de Latour, R. P., Robin, M., Bertrand, Y., Pondarré, C., Vannier, J., Neven, B., Kuentz, M., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.213207 · Cited by 141
Noubouossie, D. F., Key, N. S., & Ataga, K. I. (2015) · Blood Reviews · doi:10.1016/j.blre.2015.12.003 · Cited by 141
Maitra, P., Caughey, M., Robinson, L., Desai, P. C., Jones, S., Nouraie, M., Gladwin, M. T., Hinderliter, A., Cai, J., & Ataga, K. I. (2017) · Haematologica · doi:10.3324/haematol.2016.153791 · Cited by 137
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Steinberg, M. H. (2020) · Blood · doi:10.1182/blood.2020007645 · Cited by 136
Alvarez, O. A., Miller, S. T., Wang, W. C., Luo, Z., McCarville, M. B., Schwartz, G. J., Thompson, B., Howard, T. H., Iyer, R. V., RANA, S. R., et al. (2012) · Pediatric Blood & Cancer · doi:10.1002/pbc.24100 · Cited by 131
Self-citationStukenborg, J., Alves-Lopes, J. P., Kurek, M., Albalushi, H. M. A., Reda, A., Keros, V., Töhönen, V., Bjarnason, R. G., Romerius, P., Sundin, M., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey240 · Cited by 126
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Estepp, J. H., Smeltzer, M. P., Kang, G., Li, C., Wang, W. C., Abrams, C., Aygun, B., Ware, R. E., Nottage, K., & Hankins, J. S. (2017) · American Journal of Hematology · doi:10.1002/ajh.24906 · Cited by 88
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Sharpe, C. C., & Thein, S. L. (2014) · Blood · doi:10.1182/blood-2014-02-557439 · Cited by 78
Hankins, J. S., Aygun, B., Nottage, K., Thornburg, C., Smeltzer, M. P., Ware, R. E., & Wang, W. C. (2014) · Medicine · doi:10.1097/md.0000000000000215 · Cited by 77
Self-citationDedeken, L., Lê, P.-Q., Azzi, N., Brachet, C., Heijmans, C., Huybrechts, S., Devalck, C., Rozen, L., Mujinga, M. N., & Ferster, A. (2014) · British Journal of Haematology · doi:10.1111/bjh.12737 · Cited by 77
Gluckman, É. (2013) · Hematology · doi:10.1182/asheducation-2013.1.370 · Cited by 77
Quarmyne, M., Wei, D., Theodore, R. S., Anand, S. S., Barry, V., Adisa, O. A., Buchanan, I. D., Bost, J. E., Brown, R. C., Joiner, C. H., et al. (2016) · American Journal of Hematology · doi:10.1002/ajh.24587 · Cited by 75
Self-citationCouque, N., Girard, D., Ducrocq, R., Boizeau, P., Haouari, Z., Missud, F., Holvoet, L., Ithier, G., Belloy, M., Odièvre, M., et al. (2016) · British Journal of Haematology · doi:10.1111/bjh.14015 · Cited by 76
Galadanci, N. A., Abdullahi, S. U., Vance, L. D., Tabari, A. M., Ali, S., Belonwu, R., Salihu, A., Galadanci, A. A., Jibir, B. W., Bello‐Manga, H., et al. (2017) · American Journal of Hematology · doi:10.1002/ajh.24770 · Cited by 75
Is Sickle Cell Anemia a Neglected Tropical Disease?
Ware, R. E. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002120 · Cited by 75
Self-citationIschemia-Reperfusion Injury in Sickle Cell Disease
Ansari, J., & Gavins, F. N. E. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.12.012 · Cited by 81
Paper-based microchip electrophoresis for point-of-care hemoglobin testing
Hasan, M. N., Fraiwan, A., An, R., Alapan, Y., Ung, R., Akkus, A., Xu, J. Z., Rezac, A. J., Kocmich, N. J., Creary, M., et al. (2020) · The Analyst · doi:10.1039/c9an02250c · Cited by 73
Creary, S. E., Gladwin, M. T., Byrne, M., Hildesheim, M. E., & Krishnamurti, L. (2014) · Pediatric Blood & Cancer · doi:10.1002/pbc.24931 · Cited by 73
King, A. A., & Shenoy, S. S. (2014) · Blood · doi:10.1182/blood-2013-01-435776 · Cited by 73
Egesa, W. I., Nakalema, G., Waibi, W. M., Turyasiima, M., Amuje, E., Kiconco, G., Odoch, S., Kumbakulu, P. K., Abdirashid, S., & Asiimwe, D. (2022) · International Journal of Pediatrics · doi:10.1155/2022/3885979 · Cited by 89
AAAPT Diagnostic Criteria for Acute Sickle Cell Disease Pain
Field, J. J., Ballas, S. K., Campbell, C. M., Crosby, L. E., Dampier, C., Darbari, D. S., McClish, D. K., Smith, W. R., & Zempsky, W. T. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.12.003 · Cited by 73
Setty, Y. B. N., Key, N. S., Rao, A. K., Betal, S. G., Krishnan, S., Dampier, C., & Stuart, M. J. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09065.x · Cited by 71
Sheth, S., & Bhatia, M. (2015) · Journal of Blood Medicine · doi:10.2147/jbm.s60515 · Cited by 71
Hydroxyurea (hydroxycarbamide) for sickle cell disease
Rankine‐Mullings, A., & Nevitt, S. J. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002202.pub3 · Cited by 73
Zerra, P. E., Patel, S. R., Jajosky, R. P., Arthur, C. M., McCoy, J. W., Allen, J. W. L., Chonat, S., Fasano, R. M., Roback, J. D., Josephson, C. D., et al. (2021) · Blood · doi:10.1182/blood.2020009376 · Cited by 68
de Montalembert, M., Voskaridou, E., Oevermann, L., Cannas, G., Habibi, A., Loko, G., Joseph, L., Colombatti, R., Bartolucci, P., Brousse, V. A. M., et al. (2021) · American Journal of Hematology · doi:10.1002/ajh.26286 · Cited by 70
Metadata
- Authors
- Wang, W. C., Ware, R. E., Miller, S. T., Iyer, R. V., Casella, J. F., Minniti, C. P., Rana, S., Thornburg, C. D., Rogers, Z. R., Kalpatthi, R. V., Barredo, J. C., Brown, R. C., Sarnaik, S. A., Howard, T. H., Wynn, L. W., Kutlar, A., Armstrong, F. D., Files, B. A., Goldsmith, J. C., Waclawiw, M. A., Huang, X., & Thompson, B. W.
- Affiliations
- St. Jude Children's Research Hospital (US)
- SUNY Downstate Health Sciences University (US)
- University of Mississippi Medical Center (US)
- Johns Hopkins University (US)
- Children's National (US)
- Howard University (US)
- Duke Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- Medical University of South Carolina (US)
- University of Miami (US)
- Children's Hospital of Michigan (US)
- University of Alabama at Birmingham (US)
- Augusta University (US)
- Emory University (US)
- National Heart, Lung, and Blood Institute (US)
- Clinical Trials and Surveys Corporation (US)
- Corresponding author
- Wang, Winfred C
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 377
- Issue
- 9778
- Pages
- 1663-1672
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC3133619
- OpenAlex
- W2170086069
- Semantic Scholar
- 007f7341f1586c3f34ecd96fa415bd95116f1c85
- Cited by
- 803
- References
- 35
- Citations by year
- 2026: 46 · 2025: 42 · 2024: 57 · 2023: 49 · 2022: 58 · 2021: 54 · 2020: 58 · 2019: 67 · 2018: 50 · 2017: 64 · 2016: 52 · 2015: 61 · 2014: 50 · 2013: 45 · 2012: 25
- FWCI
- 21.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hb07156-19-0-1, n01hb07159-25-0-1, n01hb07153-18-0-1, n01hb07155-16-0-0, n01hb07158-17-0-0, n01hb07157-15-0-0, n01hb07152-18-0-0, n01hb07151-17-0-0, n01hb07150-20-0-1, n01hb07160-38-0-1, n01hb07154-21-0-0)
- National Heart, Lung, and Blood Institute (N01-HB-07154, N01-HB-07157, N01-HB-07160, N01 HB007155, N01-HB07155, N01-HB-07152, N01-HB-07153, N01 HB007150, N01-HB-07151, N01-HB-07158, N01-HB-07150, N01 HB007160, N01-HB-07159, N01-HB-07156)
- Topics
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- hydroxyurea, sickle cell disease, infants, spleen function, renal function, acute chest syndrome, pain episodes, fetal hemoglobin, brain development, mutagenicity, drug toxicity, beta-thalassemia, organ dysfunction, growth, transcranial Doppler, glomerular filtration rate, urine osmolality
- MeSH terms
- Anemia, Sickle Cell, Antisickling Agents, Blood Cell Count, Child Development, Female, Glomerular Filtration Rate, Hemoglobins, Humans, Hydroxyurea, Infant, Male, Osmolar Concentration, Pain, Spleen, United States, Urine, Biomarkers, Technetium Tc 99m Pentetate, Treatment Outcome, Ultrasonography, Doppler, Transcranial, Acute Chest Syndrome
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