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Cited by 208Fibromyalgia and Chronic Fatigue Syndrome ResearchDigital Mental Health InterventionsSleep and related disorders

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial

Nijhof, Sanne L, Bleijenberg, Gijs, Uiterwaal, Cuno SPM, Kimpen, Jan LL, van de Putte, Elise M·2012·The Lancet
DOI 10.1016/s0140-6736(12)60025-7
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Abstract

Background Chronic fatigue syndrome is characterised by persistent fatigue and severe disability. Cognitive behavioural therapy seems to be a promising treatment, but its availability is restricted. We developed Fatigue In Teenagers on the interNET (FITNET), the first dedicated internet-based therapeutic program for adolescents with this disorder, and compared its effectiveness with that of usual care.Methods Adolescents aged 12-18 years with chronic fatigue syndrome were assigned to FITNET or usual care in a 1:1 ratio at one tertiary treatment centre in the Netherlands by use of a computer-generated blocked randomisation allocation schedule. The study was open label. Primary outcomes were school attendance, fatigue severity, and physical functioning, and were assessed at 6 months with computerised questionnaires. Analysis was by intention to treat. Thereafter, all patients were offered FITNET if needed. This trial is registered, number ISRCTN59878666.Findings 68 of 135 adolescents were assigned to FITNET and 67 to usual care, and 67 and 64, respectively, were analysed. FITNET was significantly more effective than was usual care for all dichotomised primary outcomes at 6 months-full school attendance (50 [75%] vs 10 [16%], relative risk 4·8, 95% CI 2·7-8·9; p<0·0001), absence of severe fatigue (57 [85%] vs 17 [27%], 3·2, 2·1-4·9; p<0·0001), and normal physical functioning (52 [78%] vs 13 [20%], 3·8, 2·3-6·3; p<0·0001). No serious adverse events were reported.Interpretation FITNET offers a readily accessible and highly effective treatment for adolescents with chronic fatigue syndrome. The results of this study justify implementation on a broader scale.Funding Netherlands Organisation for Health Research and Development.

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Metadata

Authors
Nijhof, S. L., Bleijenberg, G., Uiterwaal, C. S., Kimpen, J. L., & van de Putte, E. M.
Affiliations
  • University Medical Center Utrecht (NL)
  • Radboud University Medical Center (NL)
Corresponding author
Nijhof, Sanne L
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
2012-04
Volume
379
Issue
9824
Pages
1412-1418
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(12)60025-7
OpenAlex
W2116645073
Cited by
208
References
36
Citations by year
2026: 4 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 16 · 2019: 22 · 2018: 16 · 2017: 18 · 2016: 8 · 2015: 18 · 2014: 11 · 2013: 25 · 2012: 16
FWCI
15.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
Radboud Universiteit
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
chronic fatigue syndrome, internet-based cognitive behavioral therapy, adolescents, FITNET, school attendance, fatigue severity, physical function, usual care comparison, web-based treatment
MeSH terms
Adolescent, Adolescent Behavior, Child, Female, Follow-Up Studies, Humans, Male, Netherlands, Patient Compliance, Reference Values, Severity of Illness Index, Therapy, Computer-Assisted, Fatigue Syndrome, Chronic, Cognitive Behavioral Therapy, Treatment Outcome, Internet

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